Internal Medicine
Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score
11 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
Predicting in-hospital mortality among patients with #COVID19 using the simple HA2T2 (hypoxia, age and troponin) score. https://t.co/FTDceIijZl @KevinManocha @bradpeltzer @MonikaSafford @ParagGoyalMD @JAHA_AHA @WeillCornell @nyphospital pic.twitter.com/vGTNSg8wyO
— Jim Cheung (@DrJCheungEP) November 10, 2020
[Not Published Yet] Randomized trial: Long-acting injectable drug every 8 weeks is highly effective in preventing HIV acquisition in women
11 Nov, 2020 | 09:17h | UTCCommentary: NIH study finds long-acting injectable drug prevents HIV acquisition in cisgender women – NIH News Releases
[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome
11 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
Excited to have been involved in this practice-changing RCT comparing Haloperidol (superior) to Ondansetron for Cannabis Hyperemesis Syndrome from @Qemerg @therealdraa_ron @savforrester Marco Sivilotti and others! Check it out!https://t.co/ylms5JIO9v
— Andrew Koch Hall (@AKHallMD) November 5, 2020
KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered
11 Nov, 2020 | 09:09h | UTCOriginal guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Podcast on chronic cough. Don’t be afraid to try empiric therapies! PPIs for GERD, antihistamines and intranasal steroids for post-nasal drip, and inhaled corticosteroids for post-viral cough are generally low-risk and will treat many cases.
11 Nov, 2020 | 09:04h | UTC#241 Chronic Cough – The Curbsiders Internal Medicine Podcast
News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer
10 Nov, 2020 | 09:41h | UTCNews Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study
Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre
Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths
11 Nov, 2020 | 09:06h | UTCIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)
Commentary on Twitter
Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF
— The Lancet (@TheLancet) November 8, 2020
Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19
10 Nov, 2020 | 09:39h | UTCEditorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science
Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases
Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present
10 Nov, 2020 | 09:37h | UTC
Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients
10 Nov, 2020 | 09:33h | UTCCommentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic
In patients hospitalized with COVID-19, right ventricular dilation or dysfunction was independently associated with a >2-fold increase in risk for mortality
10 Nov, 2020 | 09:36h | UTCCommentaries: Utility of RV Remodeling Over Risk Stratification in COVID-19 – American College of Cardiology AND Damage to heart’s right ventricle predicts a greater chance of death from COVID-19 – Weill Cornell Medical College
Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial
10 Nov, 2020 | 09:35h | UTCCommentary: Aspirin to be tested as potential COVID-19 drug in UK study – Reuters
Cohort study: Nighttime high blood pressure phenotype linked to worse cardiovascular prognosis
10 Nov, 2020 | 09:29h | UTCCommentaries: People who experience high blood pressure while sleeping have increased risk of heart attacks, strokes – News Medical / American Heart Association AND Sleeptime BP Spikes Tied to Heart Troubles – Physician’s Weekly
Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed
10 Nov, 2020 | 09:24h | UTCPerioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
What can we expect from new SARS-CoV-2 rapid tests? They promise to aid public health responses to COVID-19, since they can deliver results in a matter of minutes in the field, rather than taking days in clinical diagnostic labs
9 Nov, 2020 | 01:30h | UTCCoronavirus testing finally gathers speed – Nature
[Not published yet – presented at #ACR20] Randomized trial: Methotrexate improves function in people with knee osteoarthritis after 3 months
9 Nov, 2020 | 01:19h | UTC
Guideline synopsis for follow-up colonoscopy after polypectomy. Repeat Col in 7 to 10 y after 1 to 2 tubular adenomas (TA) < 10 mm; Repeat Col in 3 to 5 y after 3 to 4 TA < 10 mm; Repeat Col in 3 y after 5 to 10 TA < 10 mm; Repeat Col in 3 years after 1 or more TA > 10 mm
9 Nov, 2020 | 01:17h | UTCRecommendations for Follow-up Colonoscopy After Polypectomy – JAMA (free for a limited period)
Author interview: New Recommendations for How Often to Repeat Colonoscopy Following Polypectomy
Original guideline: Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology
Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack
9 Nov, 2020 | 01:16h | UTCRelated Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
[Abstract Only] Large randomized trial fails to show benefit from a multifactorial prevention strategy to prevent falls and fractures in older people
6 Nov, 2020 | 09:48h | UTCScreening and Intervention to Prevent Falls and Fractures in Older People – New England Journal of Medicine (link to abstract – $ for full-text)
Related study: A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries – New England Journal of Medicine
[Abstract Only] More than a third of older adults are prescribed potentially inappropriate drugs, study finds
6 Nov, 2020 | 09:42h | UTCOriginal study: Potentially Inappropriate Medications Are Associated with Increased Healthcare Utilization and Costs – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
JACC Review: Evaluation and management of patients with stable angina. Based on large clinical trials, medical therapy rather than revascularization is the initial management strategy for most patients
6 Nov, 2020 | 09:43h | UTCEvaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review – Journal of the American College of Cardiology (free for a limited period)
Summary: Evaluation and Management of Patients With Stable Angina – American College of Cardiology
[Abstract Only] Randomized trial: In patients with anorexia nervosa, a higher-calorie refeeding approach promotes earlier recovery with no increase in safety events during hospitalization
6 Nov, 2020 | 09:31h | UTCShort-term Outcomes of the Study of Refeeding to Optimize Inpatient Gains for Patients With Anorexia Nervosa: A Multicenter Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text0
Commentaries: Higher calorie treatment for people hospitalized with anorexia – NIH News Releases AND Higher-calorie diets for patients with anorexia nervosa shorten hospital stays – University of California – San Francisco
Commentary on Twitter
Great paper by @AndreaGarber2 showing that higher-calorie refeeding in #anorexia nervosa does not come at a higher risk of refeeding syndrome and can shorten hospital stays which is advantageous for both the patients/families and the medical system.https://t.co/aFQZKycpTX
— Jonas Steinhäuser (@JoSte95) October 30, 2020
Hot off the presses! Largest clinical trial of refeeding in #anorexianervosa shows that a higher-calorie approach is more efficacious & less costly than lower-calorie refeeding, with no increase in safety events & significant savings in healthcare costs. https://t.co/F0ciJAORdq
— UCSF EatingDisorders (@UCSF_EDP) October 20, 2020
High prevalence of pericardial involvement in college student-athletes recovering from COVID-19
5 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
The heart and #COVID19 in 54 consecutive college athletes @WVUHealth w/ echo, MRIhttps://t.co/76DvMNaeBL @JACCJournals todayhttps://t.co/hMyY8cQNln @ppsengupta1 @BritoCardio
>1/3 had resolving pericarditis with mild-moderate covid or no symptoms; no myocarditis, no controls pic.twitter.com/GTj3JZxL26— Eric Topol (@EricTopol) November 5, 2020
Postmortem lungs of COVID-19 patients show massive damage
5 Nov, 2020 | 09:06h | UTCPostmortem lungs of COVID-19 patients show massive damage- CIDRAP
Original article: Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology – EBioMedicine
NICE Guideline: Human and animal bites. Assessment, indications for antibiotic prophylaxis in uninfected bites, and choice of antibiotic are reviewed
5 Nov, 2020 | 09:02h | UTC