Internal Medicine
Randomized trial: Bamlanivimab associated with Etesevimab reduce the viral load in patients with mild to moderate COVID-19
25 Jan, 2021 | 01:36h | UTCEditorial: Neutralizing Monoclonal Antibody for Mild to Moderate COVID-19
Randomized trial: Anakinra (IL-1 receptor antagonist) does not improve outcomes in patients with mild-to-moderate COVID-19
25 Jan, 2021 | 01:37h | UTCCommentary: The right place for IL-1 inhibition in COVID-19 – The Lancet Respiratory Medicine
Commentary on Twitter
NEW Research—Anakinra did not improve outcomes in patients with mild-to-moderate #COVID19 pneumonia
CORIMUNO-ANA-1 trial from Xavier Mariette & colleagueshttps://t.co/SU1Cqmk9MJ pic.twitter.com/gLUkKpKinl
— The Lancet Respiratory Medicine (@LancetRespirMed) January 23, 2021
Systematic review: At least one third of SARS-CoV-2 infections are asymptomatic
25 Jan, 2021 | 01:33h | UTCCommentary from the authors: The day we let Covid-19 spin out of control – STAT
CDC Report: Allergic reactions including anaphylaxis after receipt of the first dose of Moderna COVID-19 vaccine
25 Jan, 2021 | 01:29h | UTCCommentary: CDC reports rare allergic reactions to Moderna’s Covid-19 vaccine – STAT
Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline
25 Jan, 2021 | 01:35h | UTCOriginal Guideline: COVID-19 rapid guideline: managing the long-term effects of COVID-19 – National Institute for Health and Care Excellence
Randomized trial: No benefit from corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients
25 Jan, 2021 | 01:28h | UTC
5 Important Things To Know About Extended Spectrum Beta-Lactamases (ESBL): Insights From A Clinical Microbiologist
25 Jan, 2021 | 00:58h | UTC
[News release – Not published yet] Lilly’s neutralizing antibody prevented COVID-19 at nursing homes, reducing risk by up to 80 percent for residents
22 Jan, 2021 | 08:40h | UTCCommentaries: Eli Lilly says its monoclonal antibody prevented Covid-19 infections in clinical trial – STAT AND Expert reaction to press release from Lilly about their neutralising antibody bamlanivimab and results from the BLAZE-2 trial looking at prevention of COVID-19 in nursing homes in the US – Science Media Centre
Clinical update: Allergic reactions including anaphylaxis after receipt of the first dose of Pfizer-BioNTech COVID-19 vaccine
22 Jan, 2021 | 08:35h | UTCAuthor interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions
Large cohort study identifies the most common hospital complications associated with COVID-19
22 Jan, 2021 | 08:36h | UTCCommentaries: Analysis of patient data reveals most common complications of COVID-19 – Medical News Today AND Study confirms most common complications associated with COVID-19 – New Medical
Commentary on Twitter
Large study of patients in the US who contracted #COVID19 confirms complications. Most common: pneumonia, respiratory failure, kidney failure, and sepsis or systemic inflammation. Read the research: https://t.co/GUUO1pgU9E @FralickMike pic.twitter.com/ZeMWEl3fi7
— CMAJ (@CMAJ) December 8, 2020
Patients, clinicians seek answers to the mystery of ‘Long COVID’
22 Jan, 2021 | 08:32h | UTCPatients, clinicians seek answers to the mystery of ‘Long COVID’ – CIDRAP
Twenty articles that critical care clinicians should read about COVID-19
22 Jan, 2021 | 08:28h | UTCTwenty articles that critical care clinicians should read about COVID-19 – Intensive Care Medicine
Commentary on Twitter
Main early papers on #COVID19 & their findings, an overview:
➡️ manifestations of severe disease
➡️ pharmacological therapy
➡️ ventilatory support in pts with #SARSCoV2 related #ARDS
➡️ healthcare organization & healthcare worker stress#FOAMcc #COVIDFOAM https://t.co/PvwsKhHn9v pic.twitter.com/QVg4zXU5TT— Intensive Care Medicine (@yourICM) January 4, 2021
Meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis
22 Jan, 2021 | 08:27h | UTCCommentary: Do antidepressants help back pain and osteoarthritis? – University of Sidney AND Antidepressants largely ineffective for back pain and osteoarthritis – The BMJ
Editorial: Antidepressants for musculoskeletal pain – The BMJ
Commentary on Twitter
Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by @bmj_latest https://t.co/pBmzSx0NLk @giovanni_ef
— BMJ Group (@bmj_company) January 21, 2021
Meta-analysis: Colchicine reduces new cardiovascular events in patients with coronary artery disease
22 Jan, 2021 | 08:23h | UTCMeta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease – The American Journal of Cardiology (link to abstract – $ for full-text)
Related randomized trials: Colchicine in patients with chronic coronary disease (study and commentaries) AND Low-Dose Colchicine Improves Outcomes after Myocardial Infarction (study and commentaries) AND Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) (study and commentary)
Commentary on Twitter
Meta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease https://t.co/EbMATgpXn4
🔽Major adverse CV events 35%
🔽Risk of MI 27%
🔽Coronary revasc 39%
🔽Stroke 53% (0.47, CI 0.28-0.81)
🔴No impact on CV mortality@mencardio #colchicine— Lempira Guevara Matheus (@Lguevaramath) October 31, 2020
Meta-analysis: Prevalence of postural hypotension in primary, community and institutional care
22 Jan, 2021 | 08:09h | UTC
[Preprint] South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma
21 Jan, 2021 | 01:28h | UTCSARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma – bioRxiv
Commentaries: Expert reaction to preprint reporting that the South African SARS-CoV-2 variant 501Y.V2 escapes neutralisation by COVID-19 donor plasma – Science Media Centre AND S.Africa virus strain poses ‘re-infection risk’: study – MedicalXpress
COVID’s toll on smell and taste: what scientists do and don’t know
21 Jan, 2021 | 01:26h | UTCCOVID’s toll on smell and taste: what scientists do and don’t know – Nature
COVID-19 testing: One size does not fit all
21 Jan, 2021 | 01:21h | UTCCOVID-19 testing: One size does not fit all – Science
Commentary on Twitter
COVID-19 testing: One size does not fit all https://t.co/zduxAcrMAA An excellent article by @michaelmina_lab and Kristian Andersen discussing the differences between diagnostic testing, surveillance testing and screening testing.
— Carlos del Rio (@CarlosdelRio7) January 8, 2021
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
21 Jan, 2021 | 01:10h | UTCSummary: Thrombolysis for treatment of acute deep vein thrombosis – Cochrane Library
Podcast: MGUS, Myeloma, and Immunology
21 Jan, 2021 | 00:53h | UTCMGUS, Myeloma, and Immunology – The Curbsiders Internal Medicine Podcast
Managing code status conversations for seriously ill older adults in respiratory failure
21 Jan, 2021 | 00:55h | UTC
Meta-Analysis: Low-intensity warfarin may be an option for patients under 65 years of age with non-valvular atrial fibrillation
21 Jan, 2021 | 00:57h | UTCMeta-Analysis Evaluating the Efficacy and Safety of Low-Intensity Warfarin for Patients >65 Years of Age With Non-Valvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)
Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19
20 Jan, 2021 | 01:55h | UTCCommentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology
Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Study: Crowded ICUs linked to increased mortality from COVID-19
20 Jan, 2021 | 01:53h | UTCCommentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP