Internal Medicine
Pancreatic Cysts—An Overview and Summary of Society Guidelines, 2021
28 Jan, 2021 | 01:19h | UTCPancreatic Cysts—An Overview and Summary of Society Guidelines, 2021 – JAMA (free for a limited period)
Acute Pancreatitis: A Review
28 Jan, 2021 | 01:20h | UTCAcute Pancreatitis: A Review – JAMA (free for a limited period)
Podcast: Acute Pancreatitis Part 1 of 2: Diagnosis
Podcast: Acute Pancreatitis Part 2 of 2: Treatment
Covid-19: Cough, fatigue, sore throat ‘more common’ in new variant
28 Jan, 2021 | 01:41h | UTCCovid-19: Cough, fatigue, sore throat ‘more common’ in new variant – BBC
[Preprint] Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19
28 Jan, 2021 | 01:49h | UTCEfficacy of Colchicine in Non-Hospitalized Patients with COVID-19 – medRxiv
Commentary on Twitter
The large colchicine RCT for covid is preprint published.
It shows some consistent directional benefit for major outcomeshttps://t.co/gxtyKnMqZ5
Since this is a pill, it's safe, cheap & an early intervention (as tested here, before hospital) these findings are very encouraging pic.twitter.com/uzTSkjftFp— Eric Topol (@EricTopol) January 27, 2021
Duration of culturable SARS-CoV-2 in hospitalized patients with Covid-19
28 Jan, 2021 | 01:47h | UTC
Editorial: Covid-19 controversies: the Tocilizumab chapter
28 Jan, 2021 | 01:46h | UTCCovid-19 controversies: the tocilizumab chapter – The BMJ
Related: Contradicting earlier trials, Tocilizumab did not improve outcomes, with signs of harm, in patients with severe Covid-19 (studies and commentaries)
4 reasons we’re seeing these worrying coronavirus variants now – Covid-19 is evolving. Why now?
28 Jan, 2021 | 01:33h | UTC4 reasons we’re seeing these worrying coronavirus variants now – Vox
Long Covid: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge
28 Jan, 2021 | 01:31h | UTCCommentary: Lung, mobility problems plague COVID-19 patients months after recovery – UPI
AHA Statement: Psychological health, well-being, and the mind-heart-body connection
27 Jan, 2021 | 01:11h | UTCNews release: Mental health is important to overall health, and heart disease prevention and treatment – American Heart Association
Commentary: The head is connected to the heart – and can influence health – American Heart Association
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
27 Jan, 2021 | 01:08h | UTCVitamin D, Calcium, Other Vitamins, and Supplements Do Not Prevent CVD – TCTMD
Original study 1: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Original study 2: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Opinion: Monoclonal antibodies yet to show important clinical benefit in patients with Covid-19
27 Jan, 2021 | 01:23h | UTCSee also: PulmCrit Wee – Follow-up Bamlanivimab study unmasks statistical chicanery
[Press release – not published yet] Neutralizing antibodies bamlanivimab and etesevimab together reduced risk of COVID-19 hospitalizations and death by 70 percent
27 Jan, 2021 | 01:22h | UTCCommentary: Lilly antibody combo therapy cuts risk of COVID-19 deaths – Reuters
Commentary on Twitter
1st Phase 3 trial results on #SARSCoV2 monoclonal antibody combination with very positive results
1035 patients: 11 (2%) v (7%) for death or hospitalization and 0 vs 10 deaths in high-risk patients, given early https://t.co/BXnwCd64O9 (press release).
Coincides w/ EUA criteria. pic.twitter.com/3MjE0XtEqF— Eric Topol (@EricTopol) January 26, 2021
WHO Updated Guideline: COVID-19 clinical management
27 Jan, 2021 | 01:26h | UTCCOVID-19 Clinical management: living guidance – World Health Organization
News release: WHO recommends follow-up care, low-dose anticoagulants for COVID-19 patients
Commentary: WHO issues new clinical advice on treating COVID-19 patients – Reuters
[Press release – not published yet] REGENERON reports positive interim data with antibody cocktail used as passive vaccine to prevent COVID-19
27 Jan, 2021 | 01:21h | UTCCommentaries: Regeneron’s antibody cocktail effective in preventing COVID-19 infection: study – Reuters AND Regeneron says monoclonal antibodies prevent Covid-19 in study – STAT AND Expert reaction to press release from Regeneron giving interim data from its REGEN-COV™ antibody cocktail trial for the prevention of COVID-19 in people at high risk of infection – Science Media Centre
Randomized trial: Remote, online support for blood pressure management at home is effective and low-cost
26 Jan, 2021 | 00:46h | UTC
Commentary on Twitter
NEW #BMJresearch has found that a digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs @RichardJMcManus https://t.co/XiNCzE0t6C
— The BMJ (@bmj_latest) January 23, 2021
Podcast: Smoking Cessation Unfiltered
26 Jan, 2021 | 00:41h | UTC
Cohort study: Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures
26 Jan, 2021 | 00:38h | UTCEditorial: Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis—Cumulative Dose and Duration Matter
Commentaries: Prolonged Use of Topical Steroids Associated with Increased Risk of Osteoporosis – Physician’s Weekly AND Potent Topical Corticosteroids Tied to Increased Fracture Risk – NEJM Journal Watch
Author Interview: Association of Topical Corticosteroids and Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA
Commentary on Twitter
In a cohort study of 723 251 users of potent or very potent topical #corticosteroids, use of these drugs was associated with increased risk of #osteoporosis and major osteoporotic fracture with a dose-response association for cumulative use https://t.co/m5Rp4n0NvK
— JAMA Dermatology (@JAMADerm) January 20, 2021
Why scientists are more worried about the Covid-19 variant discovered in South Africa
26 Jan, 2021 | 00:56h | UTCWhy scientists are more worried about the Covid-19 variant discovered in South Africa – Vox
Original study (preprint and commentaries): South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma
See also: Fast-spreading COVID variant can elude immune responses – Nature
Commentary on Twitter
Hot off the preprint press: Another new study, from the excellent @rjlessells @Tuliodna, used live virus to show that South Africa #coronavirus 501Y.V2 can in vitro escape antibody response from prior infectionhttps://t.co/mrryWtnXUu
Context here: https://t.co/V6WVSbUQGk
— Julia Belluz (@juliaoftoronto) January 22, 2021
[Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial
26 Jan, 2021 | 01:03h | UTC
Moderna COVID-19 vaccine may be less effective against variant found in South Africa
26 Jan, 2021 | 00:54h | UTCModerna Finds COVID-19 Vaccine Less Effective Against Variant Found In South Africa – NPR
Moderna Press release: Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa
See also: Expert reaction to preprint from Moderna about neutralising activity of their vaccine against new variants and announcement of plans to trial a variant booster jab targeting the South African (B.1.351) variant – Science Media Centre AND Moderna Launches Trial For Covid-19 Vaccine Booster To Tackle South African Strain – Forbes
Commentary on Twitter
🔥Moderna preprint PUBLISHED🔥
A six-fold reduction in neutralizing titers was observed with B.1.351 variant relative to prior variants Despite this reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective https://t.co/pDfgRn6Ost pic.twitter.com/VLu3iOqAda— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 25, 2021
Randomized crossover study shows lower ad libitum energy intake with a plant-based, low-fat diet compared to an animal-based, ketogenic diet
25 Jan, 2021 | 01:25h | UTCCommentary: NIH study compares low-fat, plant-based diet to low-carb, animal-based diet – NIH News Releases
Review: Ambulatory blood pressure monitoring to diagnose and manage hypertension
25 Jan, 2021 | 01:24h | UTCAmbulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension – Hypertension
Meta-analysis: Effect of micronutrient supplements on influenza and other respiratory tract infections among adults
25 Jan, 2021 | 01:17h | UTC
Commentary on Twitter (thread – click for more)
Our new article in @GlobalHealthBMJ suggests that zinc supplementation could almost halve the duration of symptoms of acute respiratory infection in adults. We also found small effects of vitamins C and D supplementation to prevent ARIs. [Thread]https://t.co/aJ4VfYFiBG
— Ibraheem Abioye (@DrAbioye) January 20, 2021
[Press Release – Not Published Yet] Colchicine reduces the risk of COVID-19-related complications: Positive results from COLCORONA trial show that colchicine is the only effective oral medication for treating non-hospitalized patients
25 Jan, 2021 | 01:43h | UTCStudy Protocol: Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA) (COVID-19) – ClinicalTrials.gov
“Patients will receive study medication colchicine 0.5 mg per os (PO) twice daily for the first 3 days and then once daily for the last 27 days.”
Commentaries: ‘Major breakthrough’ | Large study shows effectiveness of colchicine to treat COVID-19 – The Canadian AND A gout drug shows promise for Covid-19, but skeptics worry about trusting science by press release – STAT
Commentary on Twitter
Press release 🔥 #colchicine decreased ⬇️
🏥 hospitalizations 25%
🤕 use of ventilation 50%
💀 mortality 44%
in multinational trial of >4,000 non-hospitalized #COVID patientsMore: https://t.co/htMRdParq3
Full report awaited…@EricTopol @DrEricDing @MartinLandray #EBM pic.twitter.com/iodiEJBtV1
— Kari Tikkinen (@KariTikkinen) January 23, 2021
[Press Release – Not Published Yet] Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients
25 Jan, 2021 | 01:42h | UTC