Internal Medicine
Systematic review: Does behavioral support help people to stop smoking?
14 Jan, 2021 | 01:46h | UTCSummary: Does behavioural support help people to stop smoking? – Cochrane Library
Short review: How Dangerous are new COVID-19 strains?
13 Jan, 2021 | 02:31h | UTCHow Dangerous Are New COVID-19 Strains? – Council on Foreign Relations
Commentary on Twitter
How dangerous are the B.1.1.7 and 501Y.V2 hyper-transmissible strains?
by @AdamJKucharski @CFR_orghttps://t.co/aycWMN3b5h
h/t @Karl_Lauterbach pic.twitter.com/JlaFzzP06t— Eric Topol (@EricTopol) January 11, 2021
Confirmed reinfection with SARS-CoV-2 variant VOC-202012/01
13 Jan, 2021 | 02:30h | UTCConfirmed Reinfection with SARS-CoV-2 Variant VOC-202012/01 – Clinical Infectious Diseases
Commentary on Twitter
A new case report of reinfection with SARS-CoV-2 with the second episode due to the ‘new variant’ VOC-202012/01 of lineage B.1.1.7. The initial infection was mild illness while the second infection caused severe and critical illness. @InfectiousDz #CID https://t.co/hhP3gUnQSZ
— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 9, 2021
Masks and face coverings for the lay public: A narrative update
13 Jan, 2021 | 02:23h | UTCMasks and Face Coverings for the Lay Public: A Narrative Update – Annals of Internal Medicine
Commentary on Twitter (thread – click for more)
Masks work.
A new and comprehensive update from @trishgreenhalgh
et al."Evidence that the virus can be airborne (and therefore be inhaled) and that masking policies, when effectively delivered, save lives is now strong."https://t.co/Tl9VrmPNlW pic.twitter.com/zfuV774jyN
— Laura McCall #NoMassInfection (@equibotanica) December 29, 2020
Six RCTs to answer one question: what is the role of tocilizumab in COVID-19?
13 Jan, 2021 | 02:28h | UTCSix RCTs to answer one question: what is the role of tocilizumab in COVID-19? – PulmCrit
Related (study and commentaries): Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
Video (3 min): Which Covid vaccine is better? Pfizer v Oxford v Moderna
13 Jan, 2021 | 02:21h | UTCWhich Covid vaccine is better? Pfizer v Oxford v Moderna – BBC
An evidence review of face masks against COVID-19
13 Jan, 2021 | 02:26h | UTCAn evidence review of face masks against COVID-19 – Proceedings of the National Academy of Sciences
Commentary on Twitter
https://mobile.twitter.com/jeremyphoward/status/1348771993949151232
Loss of smell in mild Covid-19 cases occurs 86% of the time, study says
13 Jan, 2021 | 02:20h | UTCLoss of smell in mild Covid-19 cases occurs 86% of the time, study says – CNN
Original study: Prevalence and 6‐month recovery of olfactory dysfunction: a multicentre study of 1363 COVID‐19 patients – Journal of Internal Medicine
Randomized trial: Stable supportive shoes improve knee osteoarthritis symptoms when compared to flat flexible shoes
13 Jan, 2021 | 02:08h | UTCThe Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Summary for Patients: The Effect of Flat Flexible Versus Stable Supportive Shoes on Knee Osteoarthritis Symptoms
Commentary: Stable, Supportive Shoes Better for Knee Osteoarthritis Pain – NEJM Journal Watch
2021 ACC Expert consensus decision pathway for optimization of heart failure treatment
13 Jan, 2021 | 02:01h | UTCCommentary: ACC Issues Updated Guidance For Managing Patients With HFrEF – American College of Cardiology
HEAR or HEART Pathway – Can We Drop Troponin?
13 Jan, 2021 | 01:59h | UTCHEAR or HEART Pathway – Can We Drop Troponin? – Journal Feed
Original Study: Identification of very low-risk acute chest pain patients without troponin testing – Emergency Medicine Journal
Systematic review: Acute treatments for episodic migraine
13 Jan, 2021 | 01:56h | UTCAcute Treatments for Episodic Migraine – Agency for Healthcare Research and Quality
Full text: Acute Treatments for Episodic Migraine
Evidence summary: Acute Treatments for Episodic Migraine
Systematic review: Treatments for acute pain
13 Jan, 2021 | 01:55h | UTCTreatments for Acute Pain: A Systematic Review – Agency for Healthcare Research and Quality
Full text: Treatments for Acute Pain
Evidence summary: Treatments for Acute Pain
AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults
13 Jan, 2021 | 01:58h | UTCCommentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist
USPSTF recommends screening for Hepatitis B Virus infection in adolescents and adults
13 Jan, 2021 | 01:43h | UTCAuthor Interview: USPSTF Recommendation: Screening for Hepatitis B Virus Infection in Adolescents and Adults
Patient Page: Screening for Hepatitis B in Nonpregnant Adolescents and Adults – JAMA
Podcast: Nephrotic Syndrome vs. Glomerulonephritis
13 Jan, 2021 | 01:44h | UTC
Cohort study: Concomitant use of gabapentinoids with opioids linked to increased risk of opioid overdose and other opioid-related adverse events
13 Jan, 2021 | 01:42h | UTCCommentaries: Exploring the Combination of Gabapentinoids and Opioids for Postoperative Analgesia – JAMA Network Open AND Gabapentinoids Plus Opioids Up Overdose Risk After Surgery – MedPage Today
Commentary on Twitter
🆕 Postop concomitant use of #gabapentinoids with #opioids was associated with
👉🏼⬆️ risk of opioid overdose
👉🏼⬆️ opioid-related adverse events
🎯The absolute risk of adverse events was low.@JAMA_current @JAMASurgery
@amit_pawa @KalagaraHari @Ropivacainehttps://t.co/aw3cig2Rp8— Samer Narouze,MD,PhD,MMM (@NarouzeMD) December 30, 2020
Blood plasma treatment has limited effect for sickest COVID-19 patients
12 Jan, 2021 | 02:07h | UTCBlood plasma treatment has limited effect for sickest COVID-19 patients – Imperial College London
See also: Expert reaction to REMAP-CAP recruitment of severely ill COVID-19 patients into convalescent plasma trial being paused after initial analysis suggested it did not improve outcomes – Science Media Centre AND Trial of COVID-19 blood plasma finds no benefit in severely ill patients – Reuters
Randomized trial: Plasma therapy administered early is beneficial in high-risk elderly patients
12 Jan, 2021 | 02:05h | UTCCommentaries: Early convalescent plasma may lower risk of severe COVID in seniors – CIDRAP AND Covid-19: Early Plasma Treatment Improved Outcomes in Older Patients – Physician’s Weekly
Commentaries on Twitter
Just published @NEJM: A small, placebo-controlled randomized trial (N=160) of high IgG titer convalescent plasma administered early (within 72 hrs) for mild covid-19 to older adults (median age >70) shows benefit https://t.co/dhyFH4OwpH pic.twitter.com/14lMBBofUh
— Eric Topol (@EricTopol) January 6, 2021
Early convalescent plasma may lower risk of severe COVID in seniors@NEJM study finds that 16% of those treated with high-titer convalescent therapy developed severe #COVID19, compared with 31% in the placebo grouphttps://t.co/7hqCXsNHDM pic.twitter.com/dZDUwcjxUh
— CIDRAP (@CIDRAP) January 6, 2021
Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
12 Jan, 2021 | 01:59h | UTC
NEW Research—renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with #COVID19
RCT from Julio Chirinos & colleagues https://t.co/ZNfqJ0NsRK pic.twitter.com/Kpg6xSsWKl
— The Lancet Respiratory Medicine (@LancetRespirMed) January 8, 2021
CDC Study: Reducing quarantine to fewer than 14 days might be easier to comply with but carries some risk of spreading the virus
12 Jan, 2021 | 02:03h | UTCCommentaries: Shorter Quarantines Can Eliminate Most Contagion. Is Most Enough? New Data – Brief19 AND Some Transmission of SARS-CoV-2 Occurs After Seven, 10 Days – Physician’s Wekly
Related (guideline and commentary): Why the CDC changed its Covid-19 quarantine guidelines
Commentary on Twitter
An ongoing CDC study of household spread of COVID-19 published in MWMR finds reducing quarantine to fewer than 14 days might be easier to comply with but carries some risk of spreading the virus. Learn more: https://t.co/3HCtyxCLiO pic.twitter.com/Frepnp0QRQ
— MMWR (@CDCMMWR) January 1, 2021
CDC Study: Among young, healthy athletes exposed to Covid-19, the probability of receiving positive test results after day 10 of quarantine is low (less than 5%)
12 Jan, 2021 | 02:01h | UTC
Commentary on Twitter
A new @CDCMMWR looking at college athletes exposed to #COVID19 supports giving health departments options to potentially shorten quarantine periods to increase adherence. Learn more: https://t.co/WuPF7MWtOF. pic.twitter.com/irsA0Zn7d7
— CDC (@CDCgov) January 7, 2021
Cohort study: Prevalence and risk factors for delirium in critically ill patients with COVID-19
12 Jan, 2021 | 01:55h | UTCCommentaries: Sedation in mechanically ventilated patients with COVID-19 – The Lancet Respiratory Medicine AND Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients – Vanderbilt University Medical Center
Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms
12 Jan, 2021 | 01:38h | UTCAssociation of Fluoroquinolone Use With Short-term Risk of Development of Aortic Aneurysm – JAMA Surgery (free for a limited period)
Commentaries: Fluoroquinolones and Aortic Disease—Is It Time to Broaden the Warning? – JAMA (free for a limited period) AND Study links fluoroquinolones to higher risk of aneurysm – CIDRAP AND Analysis Links Fluoroquinolones to Increased Aortic Aneurysm Risk – Physician’s Weekly
The Top Nephrology Stories of 2020
12 Jan, 2021 | 01:33h | UTCThe Top Nephrology Stories of 2020 – NephJC