Internal Medicine
RCT: Among patients with peripheral artery disease, low-intensity exercise was significantly less effective than high-intensity exercise for improving 6-minute walk distance
7 Apr, 2021 | 01:31h | UTCEffect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this RCT of patients with PAD, low-intensity home-based exercise was less effective than high-intensity home-based exercise, and similar to the nonexercise control, for improving 6-min walk distance https://t.co/dVWCDx5hLM @NUFeinbergMed @StanfordMed @UChicagoMed @wakehealth
— JAMA (@JAMA_current) April 6, 2021
Short review | Assessment and management of dysphagia and achalasia
7 Apr, 2021 | 01:13h | UTCAssessment and management of dysphagia and achalasia – Clinical Medicine Journal
Commentary on Twitter
Diagnostic approach to dysphagia and achalasia
🆕 in this month’s @Clin_Med https://t.co/LDe7lI1Ruc pic.twitter.com/nnK09HBy8Z
— Keith Siau (@drkeithsiau) March 27, 2021
UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca
8 Apr, 2021 | 09:05h | UTC
Commentary on Twitter
Following suspensions by some countries of the COVID-19 Vaccine AstraZeneca over suspected blood clots, the MHRA confirms that the benefits of the vaccine in preventing COVID-19 far outweigh the risks. People should still go and get their COVID-19 vaccine https://t.co/zse5RUIct1
— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 7, 2021
WHO Interim statement: A causal relationship between the AstraZeneca COVID-19 vaccine and the occurrence of blood clots with low platelets is considered plausible but is not confirmed
8 Apr, 2021 | 09:09h | UTC
Commentary on Twitter (thread – click for more)
🆕 Interim statement of the #COVID19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on the AstraZeneca vaccine https://t.co/p8XMMAiUne pic.twitter.com/7DMRNFxQsX
— World Health Organization (WHO) (@WHO) April 7, 2021
AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets. The benefits of the vaccine continue to outweigh the risks for people who receive it.
8 Apr, 2021 | 09:07h | UTCCommentaries: In rare instances, AstraZeneca’s Covid-19 vaccine linked to blood clots, regulators say – STAT AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre
JCVI statement on use of the AstraZeneca COVID-19 vaccine: “JCVI currently advises that it is preferable for adults aged <30 years to be offered an alternative COVID-19 vaccine, if available.”
8 Apr, 2021 | 09:02h | UTCJCVI statement on use of the AstraZeneca COVID-19 vaccine: 7 April 2021 – GOV.UK
Commentaries: Covid: Under-30s offered alternative to Oxford-AstraZeneca jab – BBC AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre
Consensus Document: Management of the complications of long term indwelling catheters
7 Apr, 2021 | 01:20h | UTC
Video: Coronavirus Variants and Vaccines
8 Apr, 2021 | 09:00h | UTCCoronavirus Variants and Vaccines – JAMA
Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials
8 Apr, 2021 | 08:59h | UTCCommentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly
Commentary on Twitter (thread – Click for more)
https://twitter.com/gjgeersing/status/1379740743951134721
CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low”
7 Apr, 2021 | 02:00h | UTCRelated: Catching COVID from surfaces is very unlikely. So perhaps we can ease up on the disinfecting – The Conversation AND Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Identifying and managing functional cardiac symptoms
7 Apr, 2021 | 01:15h | UTCIdentifying and managing functional cardiac symptoms – Clinical Medicine Journal
Practical Guide: Perioperative Pain Management and Opioid Stewardship
7 Apr, 2021 | 01:17h | UTCPerioperative Pain Management and Opioid Stewardship: A Practical Guide – Healthcare
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
6 Apr, 2021 | 01:12h | UTCSummary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
Cohort study: Risk of suicide attempt in patients with recent diagnosis of mild cognitive impairment or dementia
7 Apr, 2021 | 01:08h | UTCRisk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Recent Diagnosis of Cognitive Impairment, Dementia May Increase Suicide Risk – Psychiatric News Alert AND Suicide Attempts Spike Soon After Dementia Diagnosis – HealthDay
Systematic review: Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men
7 Apr, 2021 | 01:10h | UTCSelective serotonin re‐uptake inhibitors for premature ejaculation in adult men – Cochrane Library
Differences in susceptibility of circulating SARS-CoV-2 variants B.1.1.7 and B.1.351 to neutralization by convalescent plasma or vaccinee (Sinopharm or Sinovac) serum
7 Apr, 2021 | 01:57h | UTCRelated studies: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination – Nature Medicine AND Pfizer coronavirus vaccine found to be moderately less effective against B.1.351 variant AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well. AND RCT: Oxford/AstraZeneca vaccine does not protect against mild-to-moderate Covid-19 due to the B.1.351 variant AND New study of Coronavirus variants predicts virus evolving to escape current vaccines, treatments AND Moderna COVID-19 vaccine may be less effective against variant found in South Africa
Commentary on Twitter
https://twitter.com/hildabast/status/1379597338956603400
Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination
7 Apr, 2021 | 01:48h | UTC
Commentary on Twitter
https://twitter.com/trishgreenhalgh/status/1379414362700517385
Opinion | New COVID variants have changed the game, and vaccines will not be enough. We need global ‘maximum suppression’
7 Apr, 2021 | 01:44h | UTC
Commentary on Twitter
✨"COVID-19 variants of concern have changed the game. We need to recognise and act on this if we as a global society are to avoid future waves of infections, yet more lockdowns and restrictions, and avoidable illness and death"✨ https://t.co/YXzqayMQFR
— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 6, 2021
What’s the new coronavirus variant in India and how should it change their COVID response?
7 Apr, 2021 | 01:42h | UTC
Large study showed no association between blood group types and increased risk of Covid-19
7 Apr, 2021 | 01:41h | UTC
Commentary on Twitter
This case-control study found blood type A was not associated with higher nor type O with lower COVID-19 susceptibility or severity. Blood types were not prognostically useful. https://t.co/P8VpvQWuwE
— JAMA Network Open (@JAMANetworkOpen) April 6, 2021
CDC Report: Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event
6 Apr, 2021 | 01:29h | UTCCommentaries: Illinois bar opening event linked to 46 Covid-19 cases, a school closure and hospitalization, CDC report says – CNN AND Bar opening linked to 29 COVID-19 diagnoses among staff and patrons, 17 more across the community affecting school, nursing home – Science Speaks: Global ID News AND 46 COVID-19 cases linked to one indoor bar event in rural Illinois: CDC – The Hill
Related: Why indoor spaces are still prime COVID hotspots – Nature
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
Chronic Coronary Syndromes in Women: Challenges in Diagnosis and Management
6 Apr, 2021 | 01:08h | UTC
Podcast: Evaluation and Management of Acute Diarrhea
6 Apr, 2021 | 00:59h | UTC#266 Diarrhea Disemboweled Part 1: Acute Diarrhea with Dr. Iris Wang – The Curbsiders
Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery
6 Apr, 2021 | 01:01h | UTCGuide to Enhanced Recovery for Cancer Patients Undergoing Surgery – Annals of Surgical Oncology
See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines