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Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

12 Apr, 2021 | 01:23h | UTC

Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients – Critical Care

 

Commentary on Twitter

 

[Preprint] Pfizer vaccine less effective for SARS-CoV-2 variant B.1.351

12 Apr, 2021 | 01:26h | UTC

Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals – medRxiv

Commentaries: South African variant may evade protection from Pfizer vaccine, Israeli study says – Reuters AND Israeli data shows South African variant able to ‘break through’ Pfizer vaccine – The Times of Israel

Related: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.

 

Another study shows intravenous radiocontrast use is not associated with reduced kidney function

12 Apr, 2021 | 00:44h | UTC

Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis – JAMA Internal Medicine

Commentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie

Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)

 

Commentary on Twitter (thread – click for more)

 

AHA Policy Statement: Reducing Nontraumatic Lower-Extremity Amputations by 20% by 2030

12 Apr, 2021 | 00:48h | UTC

Reducing Nontraumatic Lower-Extremity Amputations by 20% by 2030: Time to Get to Our Feet: A Policy Statement From the American Heart Association – Circulation

Commentary: AHA issues policy statement on reducing lower-extremity amputations – ACP Diabetes AND AHA Seeks to Drive Down Amputations 20% by 2030 – TCTMD

 

M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis

12 Apr, 2021 | 00:39h | UTC

Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver – Cochrane Library

Related Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

 

RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy

9 Apr, 2021 | 03:18h | UTC

Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial – JAMA Neurology

Author Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy

 

Commentary on Twitter

 

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine

12 Apr, 2021 | 01:20h | UTC

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine – TCTMD

Study 1: Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination – New England Journal of Medicine

Study 2: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination – New England Journal of Medicine

 

Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient

12 Apr, 2021 | 01:12h | UTC

Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN

 

EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine

12 Apr, 2021 | 01:18h | UTC

EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine – Health Policy Watch

See also: Johnson & Johnson’s COVID-19 vaccine under scrutiny at EMA after 4 ‘serious cases’ of unusual blood clots – Fierce Pharma AND J&J COVID-19 vaccine under EU review over blood clots, AstraZeneca probe grows – Reuters

 

Chinese COVID-19 vaccine maintains protection in variant-plagued Brazil

12 Apr, 2021 | 01:14h | UTC

Chinese COVID-19 vaccine maintains protection in variant-plagued Brazil – Science

Original study: [Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil (study and commentary on Twitter)

 

Short Review | How to use antihistamines

9 Apr, 2021 | 03:13h | UTC

How to use antihistamines – Canadian Medical Association Journal

 

Comprehensive Review | Pneumonia

9 Apr, 2021 | 03:14h | UTC

Pneumonia – Nature Reviews Disease Primers (free for a limited period)

Try this link if the above is paywalled.

 

ESC Position Statement: Diagnosis and treatment of cardiac amyloidosis

8 Apr, 2021 | 08:49h | UTC

Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases – European Heart Journal

 

Commentary on Twitter (thread – click for more)

 

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

12 Apr, 2021 | 01:24h | UTC

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial – The Lancet Respiratory Medicine

Commentary: Early treatment with inhaled budesonide to prevent clinical deterioration in patients with COVID-19 – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

NICE Guideline: Assessment and Management of Chronic Pain in Over 16s

8 Apr, 2021 | 08:54h | UTC

Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain – National Institute for Health and Care Excellence

News release: NICE recommends range of effective treatments for people with chronic primary pain and calls on healthcare professionals to recognise and treat a person’s pain as valid and unique to them

 

[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil

9 Apr, 2021 | 03:36h | UTC

Effectiveness of CoronaVac in the setting of high SARS-CoV-2 P.1 variant transmission in Brazil: A test-negative case-control study – medRxiv

 

Commentary on Twitter (thread – click for more)

 

Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?

9 Apr, 2021 | 03:28h | UTC

Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology

 

The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19

9 Apr, 2021 | 03:35h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19 – NIH COVID-19 Treatment Guidelines

 

Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

8 Apr, 2021 | 09:14h | UTC

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records – The Lancet Psychiatry

Commentaries: 1 in 3 Covid-19 patients are diagnosed with a neuropsychiatric condition in the next six months, large study finds – STAT AND A longer look at COVID-19 and neuropsychiatric outcomes – The Lancet Psychiatry AND Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions – The Lancet AND Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds – The BMJ AND One in three survivors of severe Covid diagnosed with mental health condition – The Guardian AND Covid-19 linked to depression and dementia, study suggests – BBC AND Expert reaction to observational study looking at neurological and psychiatric outcomes 6 months after COVID-19 – Science Media Centre AND 1 in 3 COVID Survivors Struggle With Mental Health Issues Months Later – HealthDay

 

Commentary on Twitter (thread – click for more)

 

Cohort study: One in ten have long-term effects 8 months following mild COVID-19

8 Apr, 2021 | 09:12h | UTC

One in ten have long-term effects 8 months following mild COVID-19 – Karolinska Institutet

Original study: Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers – JAMA

 

Commentary on Twitter

 

Study: Outdoor transmission accounts for 0.1% of Covid-19 cases

8 Apr, 2021 | 09:11h | UTC

Outdoor transmission accounts for 0.1% of State’s Covid-19 cases – The Irish Times

Related: Systematic review: Outdoor transmission of SARS-CoV-2 and other respiratory viruses. “The odds of indoor transmission was very high compared to outdoors (18.7 times)”

 

Meta-Analysis: Primary prevention of variceal bleeding in people with esophageal varices due to liver cirrhosis

8 Apr, 2021 | 08:45h | UTC

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library

Summary: Treatment to prevent first bleeding from dilated veins in the oesophagus resulting from advanced scarring of the liver – Cochrane Library

Related Cochrane Review: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis

 

Cancer Screening in the Coronavirus Pandemic Era: Adjusting to a New Situation

9 Apr, 2021 | 03:09h | UTC

Cancer Screening in the Coronavirus Pandemic Era: Adjusting to a New Situation – JCO Global Oncology

 

Perspective | Evidence isn’t Everything – Evidence-based medicine and statin decision-making

8 Apr, 2021 | 08:41h | UTC

Evidence isn’t Everything – Evidence-based medicine and statin decision-making

 

Commentary on Twitter

 

Podcast: Evaluation and Management of Chronic Diarrhea

8 Apr, 2021 | 08:38h | UTC

#267 Diarrhea Disemboweled Part 2: Chronic Diarrhea with Dr. Iris Wang – The Curbsiders

See also: #266 Diarrhea Disemboweled Part 1: Acute Diarrhea with Dr. Iris Wang – The Curbsiders

 

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