Internal Medicine
RCT: COVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir
23 Apr, 2021 | 08:42h | UTCCOVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir – CIDRAP
Commentary on Twitter (thread – Click for more)
1/ No benefit from Hydroxychloroquine or Lopinavir-Ritonavir on Hospitalization/Viral clearance for COVID-19 https://t.co/yhXxv26418 via @JAMANetworkOpen part of @JAMANetwork
— Priya Sampathkumar (@PSampathkumarMD) April 22, 2021
Case series of 18 male adults aged 50 years or younger with acute ischemic stroke during the convalescent phase of asymptomatic Covid-19
23 Apr, 2021 | 08:39h | UTC
Commentary on Twitter
A 💥🆕 case series highlights that adults 50 years or younger with asymptomatic COVID-19 infection diagnosed by positive SARS-CoV-2 serological test result may present with ischemic stroke during the convalescent phase of the infection
https://t.co/BVlo7Z1hgn @JAMANetworkOpen— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 22, 2021
Covid-19: More data on the increased risks to pregnant women and their newborn infants
23 Apr, 2021 | 08:44h | UTCEditorial: COVID-19 in Pregnant Women and Their Newborn Infants
Commentaries: Pregnant women with COVID-19 face high mortality rate – University of Washington School of Medicine AND Covid-19 raises risks for expectant mothers and babies, study says – CNN
Commentary on Twitter
18 country study in >2000 pregnant women with and without #COVID19 shows higher complication and death rates in symptomatic, but not asymptomatic, women with COVID-19. Their babies were at greater risk of neonatal complications, mainly due to preterm birth https://t.co/mRl8OOIMsz
— JAMA Pediatrics (@JAMAPediatrics) April 22, 2021
RCT: Single-Dose Johnson & Johnson Vaccine has 85% efficacy against severe/critical Covid-19 and maintains efficacy against variant B.1.351
22 Apr, 2021 | 08:50h | UTC
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
22 Apr, 2021 | 08:49h | UTCAudio Interview: Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky – New England Journal of Medicine
Commentaries: No evidence that Pfizer or Moderna vaccines are unsafe during pregnancy, a preliminary study says. – The New York Times AND Preliminary data show no safety concerns for pregnant women receiving COVID-19 vaccines – AAP News AND Messenger RNA COVID vaccines likely safe for pregnant women: Study – ABC News
Covid-19: What do we know about airborne transmission of SARS-CoV-2?
23 Apr, 2021 | 08:33h | UTCCovid-19: What do we know about airborne transmission of SARS-CoV-2? – The BMJ
Related: Ten scientific reasons in support of airborne transmission of SARS-CoV-2 AND Editorial: Covid-19 has redefined airborne transmission
Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”
23 Apr, 2021 | 08:19h | UTCAuthor interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library
Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro
“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”
Commentary on Twitter (thread – click for more)
Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)
— Mark Horowitz @markhoro.bsky.social (@markhoro) April 22, 2021
AHA Scientific Statement: Obesity and Cardiovascular Disease
23 Apr, 2021 | 08:22h | UTCNews Release: More belly weight increases danger of heart disease even if BMI does not indicate obesity – American Heart Association
Perioperative hemodynamic optimization: from guidelines to implementation—an experts’ opinion paper
23 Apr, 2021 | 08:21h | UTC
Systematic review: Abdominal ultrasound and alpha‐foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease
23 Apr, 2021 | 08:17h | UTC
Survey: Despite guideline recommendations, many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone
23 Apr, 2021 | 08:13h | UTCTSH Suppression for Papillary Thyroid Cancer: A Physician Survey Study – Thyroid (link to abstract – $ for full-text)
Commentary on Twitter
Hot off the press. We found that many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone, emphasizing the need for more research to better guide thyroid cancer management. @AmThyroidAssn @UMRogelCancer https://t.co/iU3ObzQxBQ
— Maria Papaleontiou, MD (@MariaPapaleont1) March 30, 2021
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
23 Apr, 2021 | 08:08h | UTCCardiovascular Outcomes in Systemic Lupus Erythematosus – American College of Cardiology
Original study: Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Do you really need to drink 8 glasses of water a day? An exercise scientist explains why your kidneys say ‘no’
23 Apr, 2021 | 08:11h | UTC
General anesthesia in end‐of‐life care: extending the indications for anesthesia beyond surgery
22 Apr, 2021 | 08:26h | UTC
Commentary on Twitter
🔐"Our redefinition of the scope and reach of general anaesthesia through end‐of‐life care, radical though it is, would recognise that anaesthetists have skills that can help alleviate suffering for the dying patient."@TaklaAntony @Assoc_Anaes #FOAMed
🔗https://t.co/51Ja7lFIBU pic.twitter.com/vnpvf484my
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) April 21, 2021
New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis
23 Apr, 2021 | 08:06h | UTC
An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria
23 Apr, 2021 | 08:05h | UTC
Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery
22 Apr, 2021 | 08:28h | UTCOpportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review – JAMA Surgery (free for a limited period)
See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines
Review: Oral Antiplatelet Therapy After Acute Coronary Syndrome
22 Apr, 2021 | 08:22h | UTCOral Antiplatelet Therapy After Acute Coronary Syndrome: A Review – JAMA (free for a limited period)
Audio Clinical Review: Dual Antiplatelet Therapy After Acute Coronary Syndrome – JAMA
Guideline: Diagnosis and Evaluation of Hypersensitivity Pneumonitis
22 Apr, 2021 | 08:21h | UTCSee also: Executive Summary
Vaccine Breakthrough Infections with SARS-CoV-2 Variants
22 Apr, 2021 | 08:47h | UTCVaccine Breakthrough Infections with SARS-CoV-2 Variants – New England Journal of Medicine
Commentary on Twitter
Mild #COVID19 symptoms developed in two fully vaccinated persons. Serum tests showed high titers of antibodies capable of neutralizing the wild-type strain of #SARSCoV2 first identified in Wuhan, China, but sequencing of the virus isolates revealed novel variants.
— NEJM (@NEJM) April 21, 2021
Opinion | Platform Trials — Beware the Noncomparable Control Group
22 Apr, 2021 | 08:44h | UTCPlatform Trials — Beware the Noncomparable Control Group – New England Journal of Medicine
ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia
21 Apr, 2021 | 07:11h | UTCSee also: Diagnostic Flow Chart
Commentary on Twitter
The ISTH has released interim guidance on vaccine-induced immune thrombotic thrombocytopenia (#VITT) to inform the management of suspected thrombosis in subjects who have recently received the AstraZeneca or Johnson & Johnson vaccine. https://t.co/qqtQtpywaf pic.twitter.com/wNmjNNDs4z
— ISTH (@isth) April 20, 2021
How COVID hurt the fight against other dangerous diseases
22 Apr, 2021 | 08:35h | UTCHow COVID hurt the fight against other dangerous diseases – Nature
Related: World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis AND WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1
Review: Long-Term Infectious Complications of Kidney Transplantation
22 Apr, 2021 | 08:16h | UTC
Cohort study: Increased bleeding risk with no therapeutic benefit with the addition of aspirin to direct oral anticoagulant therapy when there is not a clear indication
21 Apr, 2021 | 06:34h | UTCAdverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication – JAMA Internal Medicine (free for a limited period)
Commentaries: DOAC + Aspirin Common Without Clear Indication, Tied to More Bleeding – NEJM Journal Watch AND Many AFib patients wrongly prescribed aspirin therapy, study finds – UPI
Commentary on Twitter
Obs study in @JAMAInternalMed finds aspirin is often prescribed along w/ direct acting oral anticoagulant without clear reason and the combo *associates* w higher rates of bleeding https://t.co/nKsWtLnjr9
Good one @GBarnesMD
ASA is the number 1 drug I #deprescribe
— John Mandrola, MD (@drjohnm) April 19, 2021