Cohort study: Increased bleeding risk with no therapeutic benefit with the addition of aspirin to direct oral anticoagulant therapy when there is not a clear indication

Adverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication – JAMA Internal Medicine (free for a limited period)

Commentaries: DOAC + Aspirin Common Without Clear Indication, Tied to More Bleeding – NEJM Journal Watch AND Many AFib patients wrongly prescribed aspirin therapy, study finds – UPI

Commentary on Twitter

Obs study in @JAMAInternalMed finds aspirin is often prescribed along w/ direct acting oral anticoagulant without clear reason and the combo *associates* w higher rates of bleeding https://t.co/nKsWtLnjr9

Good one @GBarnesMD

ASA is the number 1 drug I #deprescribe

— John Mandrola, MD (@drjohnm) April 19, 2021