Internal Medicine
[Preprint] SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity
5 May, 2021 | 08:40h | UTCCommentary: SARS-CoV-2 antibodies are detectable up to a year after infection, finds study – News Medical
Commentary on Twitter
https://twitter.com/hildabast/status/1388963453134532609
Cohort study: Increased risk in suicide and self-harm in adult survivors of critical illness.
6 May, 2021 | 08:44h | UTCCommentary: ICU admission linked to increased risk of future suicide and self-harm – The BMJ
Commentary on Twitter
Survivors of critical illness have increased risk of suicide and self-harm, and these outcomes were associated with pre-existing psychiatric illness and receipt of invasive life support, concludes new study @shanfernands https://t.co/WOHBAdnBWK
— The BMJ (@bmj_latest) May 5, 2021
COVID has pushed medical research into remote trials, benefiting patients and scientists
5 May, 2021 | 08:38h | UTC
What’s the future of vaccines linked to rare clotting disorders? Science breaks down the latest
5 May, 2021 | 08:37h | UTC
Perspective | We may never achieve long-term global herd immunity for COVID. But if we’re all vaccinated, we’ll be safe from the worst
5 May, 2021 | 08:33h | UTCSee also: Reaching ‘Herd Immunity’ Is Unlikely in the U.S., Experts Now Believe – The New York Times (free registration required) AND We May Never Get to Herd Immunity – Think Global Health
USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)
5 May, 2021 | 08:30h | UTCDraft Evidence Review: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer
ATS Guideline: Nucleic acid–based testing for noninfluenza viral pathogens in adults with suspected community-acquired pneumonia – Testing should be considered only in patients with severe CAP and in immunocompromised patients
5 May, 2021 | 08:28h | UTCNews Release: New clinical practice guideline on community acquired pneumonia – American Thoracic Society
Microscopic Colitis: A Concise Review for Clinicians
5 May, 2021 | 08:16h | UTCMicroscopic Colitis: A Concise Review for Clinicians – Mayo Clinic Proceedings
M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required
4 May, 2021 | 08:52h | UTCProne Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases
5 May, 2021 | 08:15h | UTC
Prior SARS-CoV-2 infection boosts response to variants after first vaccine dose
4 May, 2021 | 08:51h | UTCOriginal study: Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose – Science
Commentary on Twitter (thread – click for more)
Just published @ScienceMagazine
"After one dose, individuals with *prior infection* showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351." 👍https://t.co/7cCVM6iqdP pic.twitter.com/GiC43bjwZZ— Eric Topol (@EricTopol) April 30, 2021
[Preprint] Preventing disproportionate mortality in ICU overload situations: Empirical evidence from the first COVID-19 wave in Europe – “transferring patients proactively out of developing hotspots to less affected regions, well before high ICU workload situations emerge, will improve patient outcomes”
4 May, 2021 | 08:42h | UTC
Novel coronavirus really is seasonal, study suggests
4 May, 2021 | 08:46h | UTCNovel coronavirus really is seasonal, study suggests – LiveScience
Original study: Climate and the spread of COVID-19 – Scientific Reports
[Preprint] Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – up to one-third of COVID-19 patients analyzed in this review, 89% of whom were hospitalized, experienced at least one neurological manifestation
4 May, 2021 | 08:44h | UTCCommentary: Study finds one-third of COVID-19 patients experience neurological symptoms – News Medical
M-A: In patients with atrial fibrillation, catheter ablation was associated with a 38% reduction in recurrence and a 68% reduction in hospitalizations. The rate of serious complications was 4.2% with ablation vs. 2.8% in the antiarrhythmic group, a difference that was not statistically significant.
4 May, 2021 | 08:39h | UTCAssessment of Catheter Ablation or Antiarrhythmic Drugs for First-line Therapy of Atrial Fibrillation: A Meta-analysis of Randomized Clinical Trials – JAMA Cardiology (free for a limited period)
ISCHEMIA trial – days alive out of hospital endpoint was higher in the conservative management group vs. invasive management group at 1 month (30.8 vs 28.4 days), 1 year (362.2 vs 355.9 days), and 2 years (718.4 vs 712.1 days)
4 May, 2021 | 08:41h | UTCComparison of Days Alive Out of Hospital With Initial Invasive vs Conservative Management: A Prespecified Analysis of the ISCHEMIA Trial – JAMA Cardiology (free for a limited period)
Original study: ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease AND ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease AND ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease AND ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease
Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation
4 May, 2021 | 08:38h | UTCCommentary: EHRA Updates Its Popular ‘Practical’ NOAC Guide – TCTMD
Study: Most patients who develop a non-IgE-mediated hypersensitivity reaction to nafcillin can be safely treated with cefazolin
4 May, 2021 | 08:36h | UTC
Commentary on Twitter
New case series found 90% tolerated switching to cefazolin out of 80 patients who experienced non-IgE hypersensitivity reactions to nafcillin.https://t.co/YbFeWS4n4k
Our previous metas-analysis https://t.co/sJBjrx4a3r found higher odds of these reactions with nafcillin. pic.twitter.com/SIWcSuPcct— Antibiotic Tweets (@khalideljaaly) April 28, 2021
Review: Parkinson’s disease
4 May, 2021 | 08:28h | UTCParkinson’s disease – The Lancet
Study: A high dietary sodium intake in patients with postural tachycardia syndrome reduces upright heart rate, increases plasma volume, lowers standing plasma norepinephrine, and decreases variability in heart rate
4 May, 2021 | 08:32h | UTCEffect of High Dietary Sodium Intake in Patients With Postural Tachycardia Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: High Salt Intake Benefits Patients with Postural Tachycardia Syndrome – Medical Dialogues AND Effect of High Dietary Sodium Intake in POTS Patients – American College of Cardiology
Commentary on Twitter
Great new research from Vanderbilt documenting that a high salt diet reduces standing tachycardia and norepinephrine levels in POTS, but that even with a high salt diet, POTS patients have lower blood volume than healthy individuals. https://t.co/Fy4UcPmOyB pic.twitter.com/2ozUxzK8f6
— Dysautonomia Intl. (@Dysautonomia) April 26, 2021
M-A: Tocilizumab reduces the need for mechanical ventilation in COVID-19 patients, but the randomized trials included in the analysis showed it has no significant effect on the risk of mortality or adverse events
3 May, 2021 | 05:44h | UTC
RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes
3 May, 2021 | 05:47h | UTCInvited commentary: Tocilizumab in COVID-19: some clarity amid controversy – The Lancet
Shift work is associated with positive COVID-19 status in hospitalized patients
3 May, 2021 | 05:36h | UTCShift work is associated with positive COVID-19 status in hospitalised patients – Thorax
Commentary: Shift Work Linked to Increased Risk for COVID-19 Illness – HealthDay
M-A: The viral shedding time (VST) determines disease transmission and the duration of infectiousness in SARS-CoV-2 infections – this study found that symptomatic infections, infected adults, persons with chronic diseases, and persons receiving corticosteroid treatment have longer VST
3 May, 2021 | 05:37h | UTC
Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination
3 May, 2021 | 05:43h | UTCSee also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – Centers for Disease Control and Prevention AND Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021 – Centers for Disease Control and Prevention