Internal Medicine
[#ACC21 – not published yet] 1 in 5 adults with high blood pressure also take a medicine that could be elevating their blood pressure.
10 May, 2021 | 00:58h | UTCHave high blood pressure? You may want to check your meds – American College of Cardiology
Commentary: Are You Taking a Med That’s Raising Your Blood Pressure? – HealthDay
Review: Colchicine and the heart.
10 May, 2021 | 00:56h | UTCColchicine and the heart – European Heart Journal
Related meta-analysis: Colchicine administration for percutaneous coronary intervention
Related randomized trials: Colchicine in patients with chronic coronary disease (study and commentaries) AND Low-Dose Colchicine Improves Outcomes after Myocardial Infarction (study and commentaries) AND Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT) (study and commentary)
Commentary on Twitter
Colchicine and the heart
🎯 Great review summarizing the evidence of colchicine in CV diseases @ESC_Journals https://t.co/edDw5zID5j pic.twitter.com/NqQGgdDwlX
— Enrique Santas (@SantasEnrique) May 7, 2021
RCT: Efficacy and safety of voclosporin for lupus nephritis – voclosporin + MMF + low dose corticosteroids achieved complete renal response at week 52 more often than MMF + low dose corticosteroids alone (41% vs. 23%).
10 May, 2021 | 00:48h | UTCEfficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Case-control study shows an increased risk of colorectal cancer in first degree relatives of patients with colorectal polyps.
10 May, 2021 | 00:50h | UTCCommentaries: Intestinal polyps in close relatives can increase risk of colorectal cancer – Karolinska Institutet AND Relatives’ Colonoscopy Results Could Affect Your Colon Cancer Risk – HealthDay
Commentary on Twitter
After adjusting for family history of colorectal cancer, siblings and children of patients with colorectal polyps were found to be at increased risk of colorectal cancer in this study #BMJResearch https://t.co/E30VDw3PqT
— The BMJ (@bmj_latest) May 9, 2021
One third of patients hospitalized with COVID-19 have lung changes after a year
7 May, 2021 | 08:37h | UTCCommentaries: One third of patients hospitalized with COVID-19 have lung changes after a year – University of Southampton AND An integrated understanding of long-term sequelae after acute COVID-19 – The Lancet Respiratory Medicine
Cohort study: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S. 11 excess venous thromboembolic events per 100 000 vaccinations; 2.5 excess cerebral venous thrombosis per 100 000 vaccinations.
7 May, 2021 | 08:33h | UTCEditorial: Thromboembolism and the Oxford-AstraZeneca vaccine – The BMJ
Commentaries: Thrombosis and bleeding after the Oxford-AstraZeneca covid-19 vaccination – The BMJ Opinion AND Putting risks into context: covid-19 vaccines and blood clots – The BMJ Opinion AND Expert reaction to study from Denmark and Norway looking at rare blood clots after the Oxford-AstraZeneca vaccine – Science Media Centre
Commentary on Twitter
NEW research sheds more light on rate of rare blood clots after Oxford-AstraZeneca vaccine
Rate of adverse events low; benefits of the vaccine still outweigh risks in most situations, say researchershttps://t.co/LslgvzWlWi @Pottegard
— The BMJ (@bmj_latest) May 6, 2021
Opinion | Covid-19: Sputnik vaccine rockets, thanks to Lancet boost
7 May, 2021 | 08:31h | UTCCovid-19: Sputnik vaccine rockets, thanks to Lancet boost – The BMJ
Commentary on Twitter
Journals risk being used in place of regulators when they publish studies of novel vaccines that have not yet been authorised by a major regulator @DoctorChrisVT unpicks the story of the Sputnik V vaccine https://t.co/lYf7l0lXcy
— The BMJ (@bmj_latest) May 6, 2021
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
7 May, 2021 | 08:35h | UTCReport: Estimation of total mortality due to COVID-19 – Institute for Health Metrics and Evaluation
Commentaries: New analysis finds global Covid death toll is double official estimates – STAT AND Global COVID-19 death toll more than double official estimates – IHME – Reuters
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
7 May, 2021 | 08:30h | UTC
Commentary on Twitter
We forget that covid-19 is a new disease, never having been seen until late 2019, w/ different features than any prior illness. A truly outstanding review today on its pathophysiology https://t.co/8gx2w8r1xf @LancetRespirMed @osuchm and colleagues pic.twitter.com/WGIfI2nb9B
— Eric Topol (@EricTopol) May 6, 2021
RCT: Therapeutic drug monitoring during infliximab induction does not improve disease remission in patients with chronic immune-mediated inflammatory diseases
7 May, 2021 | 08:27h | UTCEffect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
Commentary on Twitter
Study findings do not support routine use of proactive therapeutic drug monitoring during infliximab induction for improving immune-mediated inflammatory disease remission rates https://t.co/sDslkVm3u9
— JAMA (@JAMA_current) May 5, 2021
CDC Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021
7 May, 2021 | 08:28h | UTC
Commentary on Twitter
New CDC guidelines on botulism, the first botulism clinical guidelines are excellent.
🔑 points:
1) high clinical suspicion needed
2) BAT should be given in first 24 hours but can give later if progression of paralysis
3) Retreatment not recommended https://t.co/AfhrB74G0d— Joseph Marcus (@JosephMarcusID) May 7, 2021
RCT: Among patients with rheumatoid arthritis in remission, tapering conventional DMARDs using half-dose resulted in disease flares in 25% of patients compared with 6% of patients in the stable-dose group.
7 May, 2021 | 08:26h | UTCEffect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
Perspective | The weird science of the placebo effect keeps getting more interesting
7 May, 2021 | 08:17h | UTCThe weird science of the placebo effect keeps getting more interesting – Vox
Cohort study: Sugar-sweetened beverage intake in adulthood and adolescence linked to increased risk of early-onset colorectal cancer among women
7 May, 2021 | 08:22h | UTCCommentaries: Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk – BMJ AND Expert reaction to study looking at sugary drinks intake and incidence of early-onset colorectal cancer among women – Science Media Centre
In shock move, US backs waiving patents on COVID vaccines. “The development from the Biden administration draws cheers from public health researchers and ire from drugmakers.”
6 May, 2021 | 09:10h | UTCIn shock move, US backs waiving patents on COVID vaccines – Nature
See also: U.S. will back proposal to waive intellectual property rights and boost Covid-19 vaccine production – STAT AND Statement from the Executive Director of UNAIDS, Winnie Byanyima on the decision by the United States of America to support the TRIPS waiver for COVID-19 vaccines – UNAIDS AND WHO Director-General commends United States decision to support temporary waiver on intellectual property rights for COVID-19 vaccines – World Health Organization
Commentary on Twitter
These extraordinary times and circumstances of call for extraordinary measures.
The US supports the waiver of IP protections on COVID-19 vaccines to help end the pandemic and we’ll actively participate in @WTO negotiations to make that happen. pic.twitter.com/96ERlboZS8
— Ambassador Katherine Tai (@AmbassadorTai) May 5, 2021
Cohort study shows inadequate antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients.
6 May, 2021 | 09:01h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1390097665451462656
Observational study in Israel: Pfizer-BioNTech is 95.3% effective against SARS-CoV-2 infection.
6 May, 2021 | 09:04h | UTCCommentaries: Expert reaction to Israel nation-wide study looking at Pfizer vaccine effectiveness – Science Media Centre AND Covid-19: Two doses of Pfizer vaccine are “highly effective” against infection, hospital admission, and death, study finds – The BMJ
Short review: How to diagnose and manage QT prolongation in cancer patients
7 May, 2021 | 08:18h | UTCHow to Diagnose and Manage QT Prolongation in Cancer Patients – JACC: CardioOncology
Commentary on Twitter (thread – click for more)
1/3 #JACCCardioOnc Just out 🔥 in @JACCJournals , our perspective on Management of QT prolongation in patients with cancer 👉🏼 https://t.co/s2Fo6lSIFc pic.twitter.com/FamiE0huCh
— Juan Lopez-Mattei, MD (@onco_cardiology) March 16, 2021
Observational study in Qatar: Pfizer–BioNTech Covid vaccine is 89.5% effective against B.1.1.7 variant and 75.0% effective against B.1.351 variant. Vaccine effectiveness against severe, critical, or fatal disease with any SARS-CoV-2 variant was very high, at 97.4%.
6 May, 2021 | 09:06h | UTC
Commentary on Twitter
https://twitter.com/DrEricDing/status/1390107362485211136
Organ transplant recipients remain vulnerable to Covid-19 even after second vaccine dose.
6 May, 2021 | 09:03h | UTCOriginal Study: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients – JAMA
[Press release – not published yet] Moderna announces positive initial booster data against SARS-CoV-2 variants of concern.
6 May, 2021 | 08:57h | UTCModerna Announces Positive Initial Booster Data Against SARS-CoV-2 Variants of Concern – Moderna
Commentary: We just got our first evidence that Moderna’s coronavirus booster shot works to fight variants – Insider
Commentaries on Twitter
Moderna announces that a single dose of their #COVID19 booster shot provides a strong immunologic response to the variant first identified in South Africa (B.1.351) & Brazil (P.1).
This was also well tolerated.
Press release: https://t.co/q46Wx27BzI pic.twitter.com/16JpxrM4Vq
— Isaac Bogoch (@BogochIsaac) May 5, 2021
Great news
💥Single booster dose of 50 µg of mRNA-1273 or mRNA-1273.351 increased neutralizing titers against SARS-CoV-2 and two variants of concern (B.1.351, P.1)in previously vaccinated clinical trial participants💥 https://t.co/rzhDsgxEDh— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 6, 2021
Practice changing | A four-month rifapentine regiment with moxifloxacin is noninferior to the standard 6-month regimen in the treatment of tuberculosis.
6 May, 2021 | 08:56h | UTCCommentary: Four-month TB treatment matches six-month standard of care – Aidsmap
RCT: The combination of liraglutide + exercise improves weight loss maintenance more than either treatment alone.
6 May, 2021 | 08:52h | UTCCommentary: Liraglutide beneficial for post-diet weight loss maintenance – Medwire News
Review: Diagnosis and management of stable angina.
6 May, 2021 | 08:49h | UTCDiagnosis and Management of Stable Angina: A Review – JAMA (free for a limited period)
Podcast: Chronic Stable Angina—Diagnosis and Treatment – JAMA
Guideline: Diagnosis and treatment of neurogenic dysphagia.
6 May, 2021 | 08:51h | UTC