Internal Medicine
Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.
12 May, 2021 | 08:42h | UTCEditorial: Newer drug treatments for type 2 diabetes
Commentary on Twitter
New guideline provides risk-stratified recommendations about when to add SGLT-2 inhibitors or GLP-1 receptor agonists to existing treatment for adults with type 2 diabetes.#BMJInfographic provides an overview of the recommendations @will_s_t https://t.co/G7267xadmH pic.twitter.com/vKGj5xlm4Y
— The BMJ (@bmj_latest) May 11, 2021
Review: Diagnosis and management of headache.
12 May, 2021 | 08:36h | UTCDiagnosis and Management of Headache: A Review – JAMA (free for a limited period)
Audio clinical review: Diagnosis and Management of Headache, Part 1 – JAMA
RCT: Among adults with idiopathic pulmonary fibrosis, antimicrobial therapy with co-trimoxazole or doxycycline is not associated with improved outcomes.
12 May, 2021 | 08:37h | UTCEffect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among adults with idiopathic pulmonary fibrosis, addition of co-trimoxazole or doxycycline compared with usual care did not significantly improve the time to nonrespiratory hospitalization or death https://t.co/t6WQ2sifx0
— JAMA (@JAMA_current) May 11, 2021
Review: The incidence, risk, presentation, pathophysiology, treatment, and effects of perioperative acute kidney injury.
12 May, 2021 | 08:27h | UTC
Ten simple steps to improve ventilation in healthcare facilities
11 May, 2021 | 09:27h | UTCTen simple steps to improve ventilation in healthcare facilities – Essential Critical Care
Commentary on Twitter
I've written ten simple steps to improve ventilation in healthcare facilities… with no jargon and loads of photos.
With expert input from @akm5376 @vfmcneill & @kartc from @IndiaCOVIDSOS.
Download here: https://t.co/OzsDXfPavm#COVIDisAirborne pic.twitter.com/UtsRO0IgWr
— Bex Sierra (@Global_ICU) May 5, 2021
Just 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in communities
11 May, 2021 | 09:31h | UTC
Commentary on Twitter
Covid-19 is a supercarrier story. (!)
90% of the virus load (circulating virions) is harbored by only 2% of individuals
[So much for the 80/20 Pareto principle]https://t.co/zidXh7DBjt@PNASNews by @Sara_Sawyer_ @CUBoulder @BioFrontiers and colleagues pic.twitter.com/xIPpgaGLTE— Eric Topol (@EricTopol) May 10, 2021
A global database of COVID-19 vaccinations
11 May, 2021 | 09:28h | UTCA global database of COVID-19 vaccinations – Nature Human Behaviour
See website: Statistics and Research: Coronavirus (COVID-19) Vaccinations – Our World in Data
Commentaries on Twitter
Since the beginning of the COVID vaccinations we brought together the global data.
It's the most cited resource that @OurWorldInData has ever produced. Thousands of citations every week.
Just now our vaccination dataset has been published in Nature!https://t.co/COmCMNSbw2
— Max Roser (@MaxCRoser) May 10, 2021
A stunner.
One of my favorite graphics from the pandemic: the story of the unprecedented #SARSCoV2 vaccines
Published today @NatureHumBehav @OurWorldInData https://t.co/raPq8H3DSq@redouad @MaxCRoser @_HannahRitchie @EOrtizOspina @lucasrodesg @lucasrodesg @JoeHasell @appel_cam pic.twitter.com/x1LYobAOkM— Eric Topol (@EricTopol) May 10, 2021
Mild COVID-19 infection is very unlikely to cause lasting heart damage
11 May, 2021 | 09:23h | UTCMild COVID-19 infection is very unlikely to cause lasting heart damage – Imperial College London
Commentary on Twitter
Mild Covid infection is unlikely to cause lasting heart damage, according to a study led by University College London. It's the largest & most detailed study to date into mild Covid infection and its longer-term impact on the heart https://t.co/pZ0Wgnf9zp pic.twitter.com/b1T9AClQeX
— delthia ricks 🔬 (@DelthiaRicks) May 9, 2021
Cohort study: Non-steroidal anti-inflammatory drug use is not associated with higher mortality or increased severity of COVID-19
11 May, 2021 | 09:25h | UTCCommentaries: Largest study to date confirms non-steroidal anti-inflammatory medications do not result in worse COVID-19 outcomes – The Lancet AND Non-steroidal anti-inflammatory drug use in COVID-19 – The Lancet Rheumatology AND Ibuprofen, other NSAIDs not tied to worse COVID illness, death – CIDRAP
Related study with similar findings: Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID‐19 – Arthritis & Rheumatism
Commentary on Twitter
NEW Research—Non-steroidal anti-inflammatory drugs (NSAIDs) do not increase the mortality or severity of #COVID19: findings from more than 72,000 people in the ISARIC @CCPUKstudy https://t.co/NPJzuS1wAx #LancetRheumatology #OpenAccess pic.twitter.com/LjG6O7e3F8
— The Lancet Rheumatology (@TheLancetRheum) May 7, 2021
Researchers tie severe immunosuppression to chronic COVID-19 and virus variants
11 May, 2021 | 09:21h | UTCResearchers Tie Severe Immunosuppression to Chronic COVID-19 and Virus Variants – JAMA
A ‘more rapidly spreading virus’ (B.1.617 variant) is fueling India’s mega COVID-19 surge, WHO chief scientist says
11 May, 2021 | 09:16h | UTCSee also: WHO Upgrades Virus Mutation Driving India’s COVID Surge To ‘Variant of Concern’ – Global Cases Start To ‘Plateau’ – Health Policy Watch AND Why India needs oxygen more urgently than vaccines – Vox AND WHO names B1617 fourth COVID-19 variant of concern – CIDRAP
M-A: Metabolic–bariatric surgery is associated with increased long-term survival in adults with obesity, the effects being more pronounced for people with pre-existing diabetes
11 May, 2021 | 09:11h | UTCAssociation of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants – The Lancet (link to abstract – $ for full-text)
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
11 May, 2021 | 09:14h | UTCMucormycosis: The ‘black fungus’ maiming Covid patients in India – BBC
See also: Potentially fatal ‘black fungus’ infections on the rise in India’s COVID-19 patients – LiveScience AND A potentially fatal fungal infection is cropping up among India’s Covid patients. – The New York Times AND WHO says virus strain in India a ‘variant of concern’ as Europe eases curbs – MedicalXpress
Commentary on Twitter (thread – click for more)
Doctors in India are concerned about an increase in a highly fatal fungal infection affecting cases & recently recovered from #COVID19. Mucormycosis, is a mold that attacks the respiratory tract, potentially eroding facial structures & harming the brain.🧵https://t.co/1rHU2nM346
— Eric Feigl-Ding (@DrEricDing) May 10, 2021
Systematic review: Use of compression stockings by airline passengers can reduce symptomless deep vein thrombosis and leg edema
11 May, 2021 | 09:04h | UTCCompression stockings for preventing deep vein thrombosis in airline passengers – Cochrane Library
Editorial | “Peeling off musculoskeletal labels: sticks and stones may break my bones, but diagnostic labels can hamstring me forever”
11 May, 2021 | 08:59h | UTC
Commentary on Twitter
Grateful to share our new @BJSM_BMJ editorial @KarimKhan_IMHA @DrLouiseTulloh
Peeling off musculoskeletal labels: sticks and stones may break my bones, but diagnostic labels can hamstring me forever
📄🔓 https://t.co/5LAEUNK6d2#PreventingOverdiagnosis #TooMuchMedicine pic.twitter.com/ZD0CyxmGHp
— Daniel Friedman (@ddfriedman) May 6, 2021
RCT: A web-based educational intervention can reduce the need for upper endoscopy (39% intervention vs. 82% control group) in patients with uninvestigated dyspepsia
11 May, 2021 | 09:02h | UTCWeb-Based Educational Intervention for Patients With Uninvestigated Dyspepsia Referred for Upper Gastrointestinal Tract Endoscopy: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A randomized clinical trial found that web-based education on the merits of endoscopy in uninvestigated dyspepsia avoids upper gastrointestinal endoscopies in patients with dyspepsia https://t.co/7PyWNwz2Pj
— JAMA Internal Medicine (@JAMAInternalMed) April 26, 2021
New WHO Online Course: Initial approach to the acutely ill patient with COVID-19.
10 May, 2021 | 01:21h | UTC
WHO Infographic | How to care COVID-19 patients with mild symptoms at home: information for health care workers.
10 May, 2021 | 01:17h | UTCCOVID-19 home care bundle for health care workers – World Health Organization
Commentary on Twitter
How to care #COVID19 patients with mild symptoms at home: information for health care workershttps://t.co/r09i9k0zGl pic.twitter.com/i5ihXQrhzg
— World Health Organization (WHO) (@WHO) May 8, 2021
Covid-19: Most people admitted to hospital after vaccination were infected before immunity could develop, research shows.
10 May, 2021 | 01:14h | UTC
Commentary on Twitter
"#Covid19: Most people admitted to hospital after vaccination were infected before immunity could develop, research" https://t.co/wi30LkafC7
"…highlighting the importance of maintaining social distancing & understanding that immunity develops over time…"#ScienceUpFirst!
— Timothy Caulfield (@CaulfieldTim) May 7, 2021
CDC website now emphasizes coronavirus spreads in the air.
10 May, 2021 | 01:11h | UTCCDC website now emphasizes coronavirus spreads in the air – CNN
Commentary on Twitter
1/ A radical shift today by @CDCgov, finally aligning itself with science on the modes of transmission, and throwing away the 1910 error of considering "close contact" a mode of transmission!https://t.co/5pP25OTY5d
— Prof. Jose-Luis Jimenez (@jljcolorado) May 8, 2021
Here’s what’s known about the coronavirus variants.
10 May, 2021 | 01:12h | UTCHere’s what’s known about the coronavirus variants – CNN
Viewpoint | Precision Medicine for COVID-19: Phenotype Anarchy or Promise Realized?
10 May, 2021 | 01:09h | UTCPrecision Medicine for COVID-19: Phenotype Anarchy or Promise Realized? – JAMA
M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.
10 May, 2021 | 01:00h | UTCCommentaries: Fish oil supplements linked with heart rhythm disorder – European Society of Cardiology AND Could High-Dose Fish Oil Raise Odds for A-Fib in Heart Patients? – HealthDay
Commentary on Twitter
Our latest work showing an increased risk of AFib with O3FA supplementation.
Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials https://t.co/7Z8CAuDHNr @totocarbone @gbiondizoccai @MarcoDelBuono3 pic.twitter.com/A5m77y5xTE
— Dave Dixon, Professor & Chair @VCUPharmacy (@VCUDPOSChair) April 29, 2021
Perspective | Flu Has Disappeared Worldwide during the COVID Pandemic: “The public health measures that slow the spread of the novel coronavirus work really well on influenza”.
10 May, 2021 | 01:08h | UTCFlu Has Disappeared Worldwide during the COVID Pandemic – Scientific American
A restrictive fluid management strategy shows promise for acute kidney injury in a pilot randomized controlled trial.
10 May, 2021 | 00:57h | UTC
Commentary on Twitter
REVERSE-AKI restrictive fluid management vs usual care among critically ill pts with #AKI (proper initial fluid resus), multicenter feasibility RCT:
restriction? ⬇️cumulative fluid balance#RRT ➡️13% vs 30%
diuretics ↔️
usual care? ⬆️adverse events#FOAMcc https://t.co/JdKDo1XeIf pic.twitter.com/P1sOCHjkCS— Intensive Care Medicine (@yourICM) May 7, 2021