Internal Medicine
M-A: Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease – “a 5 mm Hg reduction of systolic BP reduced the risk of major CV events by about 10%, irrespective of previous diagnoses of CV disease, and even at normal or high–normal BP values”
3 May, 2021 | 05:29h | UTCCommentaries: Many more people could benefit from blood pressure-lowering medication – The Lancet AND Decisions about antihypertensive treatment should focus on reducing cardiovascular risk – The Lancet
Highly Recommended (video): The Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl)
3 May, 2021 | 05:32h | UTCThe Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl) – ZDoggMD
Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
3 May, 2021 | 05:18h | UTCCommentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.
3 May, 2021 | 05:27h | UTC
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents
3 May, 2021 | 05:22h | UTC
Randomized trial: Admission Avoidance Hospital at Home + Geriatric Assessment led to similar outcomes compared to hospital admission for older persons
3 May, 2021 | 05:13h | UTCIs Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Study: Despite clinical practice guidelines recommending cervical cancer screening every 3 years or cotesting with HPV and cytologic testing every 5 years, many women get tested much more often
3 May, 2021 | 05:19h | UTC
Study on five million Swedes finds links between blood groups and disease risks
3 May, 2021 | 05:09h | UTCNews Release: Study on five million Swedes finds links between blood groups and disease risks – Karolinska Institutet
Original Study: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk – eLife
M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients
30 Apr, 2021 | 08:33h | UTCCommentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay
AHA Statement: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – “There is a lack of randomized clinical trials that have evaluated CVD outcomes among individuals with stage 1 hypertension and a low 10-year ASCVD risk”
30 Apr, 2021 | 08:37h | UTCNews Release: If slightly high blood pressure doesn’t respond to lifestyle change, medication can help – American Heart Association
Top Things to Know: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – American Heart Association
Commentary: The Hypertension Pandemic: Need for a Strategic Evidence-based Response – American Heart Association
Cohort Study: The risk of overdose with concomitant use of Z-Drugs (zolpidem, zopiclone, zaleplon) and prescription opioids is significantly increased
30 Apr, 2021 | 08:32h | UTCThe Risk of Overdose With Concomitant Use of Z-Drugs and Prescription Opioids: A Population-Based Cohort Study – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Co-prescribing Opioids, Z-Drugs May Increase Risk of Overdose – Psychiatric News Alert
AHA Statement: Prevention of Viridans Group Streptococcal Infective Endocarditis – Antibiotic prophylaxis for invasive dental procedures is suggested only for high-risk patients with the following conditions: 1) cardiac prosthetic valve; 2) previous infective endocarditis; 3) congenital heart disease; or 4) previous heart transplant
30 Apr, 2021 | 08:35h | UTCNews release: Good dental health may help prevent heart infection from mouth bacteria – American Heart Association
Top Things to Know: Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Slide set: Prevention of Viridans Group Streptococcal Infective Endocarditis
Commentaries: Commentary for Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Commentary on Twitter (thread – click for more)
In 2007, antibiotic prophylaxis to prevent VGS IE was scaled back.
“There was no convincing evidence that VGS IE frequency, morbidity, or mortality has increased since 2007.”
Thanks Drs. @LBaddour1, Daniel DeSimone and Walter Wilsonhttps://t.co/r9It8c3IwA pic.twitter.com/EO3gcKZAzG
— Mayo Clinic Infectious Diseases (@MayoClinicINFD) April 18, 2021
AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”
30 Apr, 2021 | 08:25h | UTCNews release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association
Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19
30 Apr, 2021 | 08:22h | UTCCommentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND Expert reaction to study looking at a potential link between body weight and risk of severe COVID-19, especially for younger adults – Science Media Centre
Commentary on Twitter (thread – click for more)
NEW—Study of health records of nearly 7 million people in England found that the risk of worse outcomes from #COVID19 starts rising in people with a BMI above 23kg/m2—considered to be in the healthy range.
Read in @TheLancetEndo: https://t.co/5ibn3yb1xO 1/2 pic.twitter.com/4MwnGq95Sz
— The Lancet (@TheLancet) April 29, 2021
Debate: Should masks be worn outdoors?
30 Apr, 2021 | 08:21h | UTCShould masks be worn outdoors? – The BMJ
Commentaries: Experts debate on wearing masks outdoors – News Medical AND Do masks need to be worn outdoors? – Advanced Science News
Commentary on Twitter (thread – click for more)
Who do so many of us go off about outdoor masking?
Because if governments can show its people that it's taking #COVID19 seriously by focusing on outdoor masking while ignoring the living and working conditions driving so many infections, we'll get nowhere.#endpandemictheatre
— Stefan Baral (@sdbaral) April 29, 2021
Household COVID-19 risk and in-person schooling – “While in-person schooling is associated with household COVID-19 risk, this risk can likely be controlled with properly implemented school-based mitigation measures”
30 Apr, 2021 | 08:19h | UTCHousehold COVID-19 risk and in-person schooling – Science
Commentary on Twitter
After analyzing responses from the #COVID19 Symptom Survey, @JustinLessler et al. find support for the idea that in-person schooling increases COVID-19 risk to household members; but also evidence that common mitigation measures can reduce this risk. https://t.co/DFtCoN0FEE pic.twitter.com/gxt7nkhdMb
— Science Magazine (@ScienceMagazine) April 29, 2021
COVID-19 ‘brain fog’ inspires search for causes and treatments
30 Apr, 2021 | 08:13h | UTCCOVID-19 ‘brain fog’ inspires search for causes and treatments – Science (a few articles per month are free)
Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose
29 Apr, 2021 | 08:44h | UTCNews release: One dose of COVID-19 vaccine can cut household transmission by up to half – Public Health England
Original study (preprint): Impact of vaccination on household transmission of SARS-COV-2 in England – Public Health England
Commentaries: Covid-19: One dose of vaccine cuts risk of passing on infection by as much as 50%, research shows – The BMJ AND Covid: One dose of vaccine halves transmission – study – BBC
Review: COVID-19-associated coagulopathy and antithrombotic agents – In non-critically ill hospitalized patients, therapeutic dose anticoagulation may improve clinical outcomes. In critically ill patients, this same treatment does not improve outcomes, and prophylactic dose anticoagulation is recommended
29 Apr, 2021 | 08:46h | UTCRelated: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit
Commentary on Twitter
🆕💥💥State of the Art Review Article @TheLancetHaem by @MiddeldorpS
COVID-19-associated coagulopathy
Excellent explanation for the pathophysiology and great summary for the major RCTs and clinical guidelines https://t.co/NxP06KP2Hm pic.twitter.com/qHzyDsUZpt— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 28, 2021
CDC Study: Pfizer-BioNTech and Moderna vaccines reduce Covid-19 hospitalization risk by 64% after the first dose and 94% after the second dose among adults aged ≥65 years
29 Apr, 2021 | 08:42h | UTCCommentaries: Pfizer/Moderna Vaccine Protection: 64% at First Dose, 94% at Second – HealthDay AND Pfizer and Moderna vaccines reduce Covid-19 hospitalization risk by 94% among older adults, CDC study says – CNN
Commentary on Twitter
New @CDCMMWR has good news: mRNA COVID-19 vaccines (Pfizer-BioNTech, Moderna) reduced the risk of #COVID19-related hospitalization by 94% among fully vaccinated people 65+. CDC recommends getting a COVID-19 vaccine to prevent severe COVID-19 illness: https://t.co/W4SFuV6wQp. pic.twitter.com/Jf4ph2rl4s
— CDC (@CDCgov) April 28, 2021
Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”
29 Apr, 2021 | 08:36h | UTC
ACP Guideline: Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients – “use high-flow nasal oxygen rather than noninvasive ventilation in hospitalized adults for the management of acute hypoxemic respiratory failure”
29 Apr, 2021 | 08:34h | UTC
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
29 Apr, 2021 | 08:31h | UTCBritish Society of Gastroenterology guidelines on the management of irritable bowel syndrome – Gut
Commentary on Twitter (thread – click for more)
Here are the new @BritSocGastro guidelines for #IBS in @Gut_BMJ! I'll summarize in 🧵 ⬇️⬇️⬇️!
😖💩🦠🧠🥦🍞💊#GITwitter #GI #gut #braingut #motility #DGBI #FGID #microbiome #probiotics #MedTwitter #MedEd https://t.co/zbXoPbKgHO
— John Damianos, M.D. (@john_damianosMD) April 26, 2021
AHA Scientific Statement: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormonal therapies
29 Apr, 2021 | 08:33h | UTCNews release: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormones – American Heart Association
Top Things to Know: Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System – American Heart Association
Commentaries: Hormonal Therapy for Breast and Prostate Cancer: Lessons and Opportunities – American Heart Association AND Hormonal Based Therapies in the Treatment of Breast and Prostate Cancer – balancing the risks! – American Heart Association AND Hormone Cancer Therapies Increase CV Risk: AHA Scientific Statement – TCTMD AND Closely Monitor Heart Health in Cancer Patients Who Get Hormonal Therapies: AHA – HealthDay
M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage
29 Apr, 2021 | 08:28h | UTC