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Internal Medicine

Systematic Review: Models of COVID-19 vaccine prioritization – “for countries seeking to minimize deaths, prioritizing vaccination of senior adults was the optimal strategy and for countries seeking to minimize cases the young were prioritized”.

2 Dec, 2021 | 10:02h | UTC

Models of COVID-19 vaccine prioritisation: a systematic literature search and narrative review – BMC Medicine

 

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

2 Dec, 2021 | 10:04h | UTC

Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence – Drugs

Related:

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

ERS guideline on non-CPAP therapies for obstructive sleep apnea.

2 Dec, 2021 | 09:56h | UTC

European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea – European Respiratory Review

 

AHA Scientific Statement: Supporting physical activity in patients and populations during life events and transitions.

2 Dec, 2021 | 09:53h | UTC

Supporting Physical Activity in Patients and Populations During Life Events and Transitions: A Scientific Statement From the American Heart Association – Circulation

News Release: Major life events influence level of physical activity, may negatively impact heart health – American Heart Association

 

The ‘ten commandments’ for the 2021 ESC Guidelines on CVD prevention.

2 Dec, 2021 | 09:45h | UTC

The ‘ten commandments’ for the 2021 ESC Guidelines on CVD prevention – European Heart Journal

Original Article: #ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

 

Guideline: Management of ureteral calculi.

2 Dec, 2021 | 09:54h | UTC

Canadian Urological Association guideline: Management of ureteral calculi – Abridged version – Canadian Urological Association Journal

Related Guidelines:

Renal and ureteric stones: assessment and management – National Institute for Health and Care Excellence

Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement – Journal of Nephrology

The Urological Association of Asia clinical guideline for urinary stone disease – International Journal of Urology

 

Chronic cough: new insights and future prospects.

2 Dec, 2021 | 09:43h | UTC

Chronic cough: new insights and future prospects – European Respiratory Review

 

E-cigarettes may be independently linked to erectile dysfunction.

2 Dec, 2021 | 09:44h | UTC

News Release: E-cigarettes may be independently linked to erectile dysfunction, new research finds – NYU Langone Health

Original Study: Association of E-Cigarettes with Erectile Dysfunction: The Population Assessment of Tobacco and Health Study – American Journal of Preventive Medicine

 

Cohort Study: Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease.

2 Dec, 2021 | 09:47h | UTC

Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study – The BMJ

 

Commentary from the author on Twitter (thread – click for more)

 

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.

1 Dec, 2021 | 09:56h | UTC

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID – STAT

See also: An FDA panel supports Merck COVID drug in mixed vote – NPR

Related:

[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Using wearable data, a real-time alerting system can be used for the early detection of Covid-19 and other stress events.

1 Dec, 2021 | 09:59h | UTC

Real-time alerting system for COVID-19 and other stress events using wearable data – Nature Medicine

Commentary: Scientists develop a smartwatch-based device for early detection of COVID-19 – News Medical

 

Commentary on Twitter

 

Another randomized trial showed convalescent plasma does not benefit patients hospitalized with Covid-19.

1 Dec, 2021 | 09:49h | UTC

Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia: A Randomized Clinical Trial – JAMA Network Open

Related:

M-A: Convalescent plasma does not reduce mortality in COVID-19.

RCT: Another study shows convalescent plasma does not improve outcomes in critically ill patients with Covid-19.

RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 

Cohort study: Allergic conditions linked to lower COVID-19 infection risk.

1 Dec, 2021 | 08:52h | UTC

News Release: Allergic conditions linked to lower COVID-19 infection risk – BMJ

Original Study: Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) – Thorax

 

NICE Guideline | Tobacco: preventing uptake, promoting quitting, and treating dependence.

1 Dec, 2021 | 08:50h | UTC

Tobacco: preventing uptake, promoting quitting and treating dependence – National Institute for Health and Care Excellence

 

Systematic Review: Are there ways to improve stop-smoking treatment in primary care to help more people quit smoking?

30 Nov, 2021 | 10:03h | UTC

Summary: Are there ways to improve stop-smoking treatment in primary care to help more people to quit smoking? – Cochrane Library

Original Study: Strategies to improve smoking cessation rates in primary care – Cochrane Library

 

Guideline Interventions for the management of acute and chronic low back pain.

30 Nov, 2021 | 10:15h | UTC

Interventions for the Management of Acute and Chronic Low Back Pain: Revision 2021 – Journal of Orthopaedic & Sports Physical Therapy

 

Commentary on Twitter

 

Systematic Review: Anticoagulants for acute ischemic stroke.

30 Nov, 2021 | 10:01h | UTC

Summary: Early treatment with blood-thinning drugs for people who have had a stroke – Cochrane Library

Original Study: Anticoagulants for acute ischaemic stroke – Cochrane Library

 

WHO Technical Brief and Priority Actions: Enhancing Readiness for Omicron.

30 Nov, 2021 | 08:46h | UTC

Enhancing Readiness for Omicron (B.1.1.529): Technical Brief and Priority Actions for Member States – World Health Organization

Commentaries:

The World Health Organization warns of very high risk posed by the omicron variant – NPR

Omicron Covid variant poses very high global risk, says WHO – The Guardian

See also the latest articles on the subject:

Statement On Omicron Variant – Infectious Diseases Society of America

Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear – The BMJ

Helen Salisbury: Omicron—panic mongering or appropriate caution? – The BMJ

The Omicron variant underscores the global stakes of Covid-19 vaccine inequity – STAT

EXPLAINER: What we know and don’t know about omicron variant – Associated Press

Omicron: How do you detect it? – BBC

Are new COVID variants like Omicron linked to low vaccine coverage? Here’s what the science says – The Conversation

Omicron: why the WHO designated it a variant of concern – The Conversation

It looks like Omicron causes milder illness – is this how COVID becomes endemic? – The Conversation

As Omicron spreads, studies suggest that travel bans alone don’t do much good – NPR

 

Benzodiazepines: Uses, dangers, and clinical considerations.

30 Nov, 2021 | 09:59h | UTC

Benzodiazepines: Uses, Dangers, and Clinical Considerations – Neurology International

 

Transient Ischemic Attack: Emergency Department Evaluation and Disposition.

30 Nov, 2021 | 09:56h | UTC

TIA: Emergency Department Evaluation and Disposition – emDocs

Related:

AHA/ASA Guideline: Prevention of stroke in patients with previous stroke and transient ischemic attack – prevention efforts should be based on the cause of the first ischemic event.

Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence

Canadian Stroke Best Practice Recommendations for Acute Stroke Management

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.

Prospective validation of Canadian TIA Score for subsequent stroke risk after transient ischemic attack

Systematic review: Multiple vs. fewer antiplatelet agents for preventing early recurrence after ischemic stroke or transient ischemic attack

 

Podcast: Metabolic Alkalosis and Hypokalemia.

30 Nov, 2021 | 09:57h | UTC

#308 Metabolic Alkalosis and Hypokalemia: Kidney Boy Returns! – The Curbsiders

 

Preliminary RCT found prostacyclin may improve outcomes in mechanically ventilated patients with COVID-19 and severe endotheliopathy.

30 Nov, 2021 | 08:42h | UTC

Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized, Clinical Trial – American Journal of Respiratory and Critical Care Medicine

News release: Well-known drug could help the most severely affected COVID-19 patients in intensive-care departments – by University of Copenhagen

 

Commentary from the author on Twitter (thread – click for more)

 

ESCMID COVID-19 Living guidelines: drug treatment and clinical management.

30 Nov, 2021 | 08:40h | UTC

ESCMID COVID-19 Living guidelines: drug treatment and clinical management – Clinical Microbiology and Infection

 

WHO Update on Omicron + Several Articles on the Subject.

28 Nov, 2021 | 21:38h | UTC

Update on Omicron – World Health Organization

Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern – World Health Organization

See also:

Omicron COVID-19 variant: Africa CDC statement

Expert reaction to B.1.1.529 variant situation in South Africa; and UK travel restrictions in response – Science Media Centre

Threat Assessment Brief: Implications of the emergence and spread of the SARS-CoV-2 B.1.1. 529 variant of concern (Omicron) for the EU/EEA – European Centre for Disease Prevention and Control

‘Patience is crucial’: Why we won’t know for weeks how dangerous Omicron is – Science

Scientists rapidly identified the Omicron variant. But firm answers about its impact could take weeks – STAT

New Covid variant: Will new measures against Omicron work? – BBC

Vaccine inequity and hesitancy made the Omicron variant more likely, scientists say – CNN

Travel bans aren’t the answer to stopping new COVID variant Omicron – The Conversation

Scientists sharing Omicron data were heroic. Let’s ensure they don’t regret it – The Guardian

The Omicron variant reveals the true global danger of ‘vaccine apartheid’ – The Guardian

We Know Almost Nothing About the Omicron Variant – The Atlantic

Covid: New Omicron variant not a disaster, says Sage scientist – BBC

New Covid variant: Will new measures against Omicron work? – BBC

World is put on high alert over the Omicron coronavirus variant – CNN

Moderna Announces Strategy to Address Omicron (B.1.1.529) SARS-CoV-2 Variant – Moderna

Omicron is the new COVID kid on the block: five steps to avoid, ten to take immediately – The Conversation

What’s known and unknown about Omicron, the coronavirus variant identified in South Africa – STAT

The new variant is worrying – but it doesn’t change how we tackle Covid – The Guardian

Omicron: everything you need to know about new Covid variant – The Guardian

Omicron variant unlikely to reboot Covid in UK, expert says – The Guardian

UK detects Omicron cases, as more countries eye new COVID-19 variant – CIDRAP

New COVID variant alarms researchers, triggers travel bans – CIDRAP

The omicron variant spreads across Europe as new travel bans take effect – NPR

What to know about omicron, the new COVID variant – NPR

What we know about the Omicron variant – CNN

The new Omicron variant is a pandemic gut check – CNN

Newly discovered Covid-19 variant B.1.1.529 is ‘red flag’ but US needs to learn more, Fauci says – CNN

Omicron, a new Covid-19 variant with high number of mutations, sparks travel bans and worries scientists – CNN

What to know about the omicron variant of the coronavirus – The Washington Post

 

Commentary on Twitter (thread – click for more)

 

M-A: Observational data on the effectiveness of COVID-19 vaccines.

30 Nov, 2021 | 08:37h | UTC

Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis – International Journal of Infectious Diseases

 

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