Preliminary RCT found prostacyclin may improve outcomes in mechanically ventilated patients with COVID-19 and severe endotheliopathy.

Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized, Clinical Trial – American Journal of Respiratory and Critical Care Medicine

News release: Well-known drug could help the most severely affected COVID-19 patients in intensive-care departments – by University of Copenhagen

Commentary from the author on Twitter (thread – click for more)

Our RCT on endothelial rescue (COMBAT COVID19) is out: Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy (COMBAT COVID19). https://t.co/dkvQIP4hP3 @ATSBlueEditor 1/6

— Jakob Stensballe (@J_Stensballe) November 24, 2021