Vaccines
Cohort Study: Effectiveness of homologous vs. heterologous booster doses for an inactivated SARS-CoV-2 vaccine.
26 Apr, 2022 | 08:06h | UTCCommentaries:
COVID-19 vaccine booster strategy: striving for best practice – The Lancet Global Health
Covid-19: Mix and match booster vaccination approach offers best protection, study reports – The BMJ
Commentary on Twitter
Effectiveness of homologous and heterologous booster doses for an inactivated SARS-CoV-2 vaccine: a large-scale prospective cohort study https://t.co/0k7WlphoDV Heterologous booster provided ⬆️ protection than homologous one, especially when Coronavac vaccine had been used.
— Carlos del Rio (@CarlosdelRio7) April 25, 2022
Studies highlight meningitis vaccine’s potential against gonorrhea.
20 Apr, 2022 | 10:06h | UTCCommentary: Studies highlight meningitis vaccine’s potential against gonorrhea – CIDRAP
News Release: Threat of untreatable gonorrhoea could be tackled using an existing meningitis vaccine – The Lancet
Study 1: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Study 2: Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial.
19 Apr, 2022 | 02:25h | UTCOmicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial – Reuters
Commentary on Twitter
In China, #Omicron-specific vaccines are slated for clinical trials. The vaccine candidates were developed by a Sinopharm subsidiary and Sinovac Biotech. The vaccines are headed to clinical trials in Hong Kong https://t.co/6Y9LsGCKbn
— delthia ricks ? (@DelthiaRicks) April 17, 2022
A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease.
19 Apr, 2022 | 02:14h | UTC
Commentary on Twitter
???Systematic Review collected efficacy & effectiveness values by vaccine platform, disease outcome, number of doses, & SARS-CoV-2 variants
The spread of the Omicron beginning late 2021 is at least partially driven by reductions in vaccine effectiveness https://t.co/A7hDTQGY4K— Antibiotic Steward Bassam Ghanem?? (@ABsteward) April 18, 2022
M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.
18 Apr, 2022 | 10:32h | UTCCommentaries:
Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet
Study explores myopericarditis incidence and COVID-19 vaccination – News Medical
Commentary on Twitter
NEW—Myopericarditis following #COVID19 vaccination is rare, finds international study published in @LancetRespirMed: https://t.co/d3ZRvTWrGB pic.twitter.com/6sHiRyEbTk
— The Lancet (@TheLancet) April 11, 2022
A nationwide observational analysis in Israel showed a fourth dose of the Pfizer vaccine may reduce the short-term risk of Covid-19–related outcomes.
14 Apr, 2022 | 08:51h | UTCEditorial: Covid-19 Boosters — Where from Here?
Related:
COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.
Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Covid-19: Fourth vaccine doses—who needs them and why?
[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.
Commentary on Twitter
In Israel, a fourth dose of BNT162b2 vaccine effective in reducing the short-term risk of Covid-19–related outcomes among those who had received a third dose at least 4 mos earlier. https://t.co/WtHiR9WbLW pic.twitter.com/yzWRLlgHUi
— NEJM (@NEJM) April 13, 2022
RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.
14 Apr, 2022 | 08:43h | UTCEfficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT: Single-dose HPV vaccination found effective among young African women.
12 Apr, 2022 | 10:08h | UTCEfficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence
News Releases:
Study boosts support for single-dose HPV vaccine regimen – University of Washington
Related:
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
Commentary on Twitter (thread – click for more)
? GAME CHANGER ?
One-dose Human Papillomavirus (#HPV) vaccine offers solid protection against cervical cancer: WHO https://t.co/3uWlZlCCVK pic.twitter.com/ZKDvpf2qog— World Health Organization (WHO) (@WHO) April 11, 2022
M-A: Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia.
8 Apr, 2022 | 10:50h | UTCRelated:
Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.
Review: Vaccine-induced immune thrombotic thrombocytopenia.
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.
7 Apr, 2022 | 10:00h | UTCRelated:
Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Covid-19: Fourth vaccine doses—who needs them and why?
[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.
Commentary on Twitter (thread – click for more)
#JustPublished!#ECDC and @EMA_News issue advice on fourth doses of mRNA #COVID19 vaccines.
Read the full joint statement: https://t.co/hBuOlrfKOD pic.twitter.com/aO5vSyYvTk
— ECDC (@ECDC_EU) April 6, 2022
Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.
5 Apr, 2022 | 09:46h | UTCRelated:
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Covid-19: Fourth vaccine doses—who needs them and why?
[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.
Commentary on Twitter
The evidence on 4th doses of Covid vaccines & the thorny question of age thresholds – 50? 55? 60? 65? 70? 75? 80? Each has been set by at least one country… | New @PLOS https://t.co/4tJ0o1fUC1
— Hilda Bastian, PhD (@hildabast) April 1, 2022
RCT: Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D).
5 Apr, 2022 | 08:50h | UTCInvited Commentary: DNA vaccines join the fight against COVID-19 – The Lancet
Commentary on Twitter
DNA-based #COVID19 vaccine, ZyCoV-D, demonstrates efficacy, safety, and immunogenicity, according to interim analysis of phase 3 trial conducted in India.
More: https://t.co/bI2eXdbOvB pic.twitter.com/tMuHrA1kz6
— The Lancet (@TheLancet) April 2, 2022
Case-control study: In children 5 to 11 years of age, the Pfizer vaccine showed an effectiveness of 68% against hospitalization caused by the Omicron variant.
31 Mar, 2022 | 08:37h | UTCCommentary: COVID vaccination of children age 5-11 cut omicron hospitalizations by 68% – Children’s Hospital Boston
Commentary on Twitter
BNT162b2 vaccination reduced the risk of omicron-associated hospitalization by two thirds among children 5 to 11 years of age. https://t.co/mQcchQqbtH pic.twitter.com/Qzy8qKg1wC
— NEJM (@NEJM) March 30, 2022
[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.
30 Mar, 2022 | 10:44h | UTCSecond Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old – Research Square
Commentaries:
Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s – Health Policy Watch
Fourth COVID-19 vaccine dose substantially reduces mortality in the elderly – News Medical
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
30 Mar, 2022 | 10:42h | UTCU.S. approves second Covid-19 booster for people 50 and older – STAT
FDA OKs second COVID booster shot for older Americans – CIDRAP
Opinion: Global vaccination must be swifter.
29 Mar, 2022 | 10:12h | UTCGlobal vaccination must be swifter – Nature
Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years.
28 Mar, 2022 | 10:01h | UTCModerna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years – STAT
Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.
28 Mar, 2022 | 09:51h | UTCAssociation of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA
See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA
Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA
News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet
[Preprint] Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study.
25 Mar, 2022 | 09:47h | UTC
Commentary on Twitter
Pleased to share our study showing that there is no evidence of an increased risk of death in young people after COVID-19 vaccination in England
Great collaboration with @kamleshkhunti @amibanerjee1 and others not on twitter!https://t.co/EV4xmDWeyB pic.twitter.com/VQy2PtCxeC
— Vahé Nafilyan (@Vnafilyan) March 24, 2022
RCT: Safety and efficacy of a third dose of the Pfizer Covid-19 vaccine during the Delta wave.
24 Mar, 2022 | 09:46h | UTCSafety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine
Commentary on Twitter
A third dose of the BNT162b2 vaccine administered a median of 10.8 months after the second dose provided 95.3% efficacy against Covid-19 as compared with two doses. #COVID19 #IDTwitter https://t.co/IeHOgVhU8a pic.twitter.com/wValXSdyHX
— NEJM (@NEJM) March 23, 2022
Effectiveness of the Johnson & Johnson vaccine in health-care workers in South Africa in a period when the beta and then the delta SARS-CoV-2 variants of concerns were dominant.
21 Mar, 2022 | 09:43h | UTCInvited Commentary: Sisonke: reaching several goals together – The Lancet
Commentary on Twitter (thread – click for more)
Single-dose Ad26.COV2.S vaccine in healthcare workers in South Africa shows effectiveness against severe #COVID19 outcomes—and against beta and delta variants, study indicates.https://t.co/S13Ia1H8BT pic.twitter.com/XgbXGcT9XR
— The Lancet (@TheLancet) March 19, 2022
Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.
21 Mar, 2022 | 09:37h | UTCMyocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel – JAMA
Related:
Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.
Myocarditis after BNT162b2 vaccination in Israeli adolescents.
[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.
Heart-inflammation risk from Pfizer COVID vaccine is very low.
Study finds no increased risk of rare neurological events after covid vaccination.
18 Mar, 2022 | 09:31h | UTCNews Release: Study finds no increased risk of rare neurological events after covid vaccination – BMJ Newsroom
Editorial: The neurological safety of covid-19 vaccines
Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.
17 Mar, 2022 | 09:12h | UTCEfficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron – New England Journal of Medicine
Related: [Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Effectiveness of the Sputnik V, AstraZeneca, and Sinopharm vaccines for the risk of infection and death due to COVID-19 in people older than 60 years in Argentina.
17 Mar, 2022 | 09:10h | UTCCommentary: Evaluating COVID-19 vaccines in the real world – The Lancet