Infectious Diseases (all articles)
Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.
13 Jun, 2022 | 10:46h | UTCOutbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)
Commentary on Twitter
Outbreak of non-A-E hepatitis in children, ?? data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
?https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz— Intensive Care Medicine (@yourICM) June 10, 2022
WHO Interim Guidance: Clinical management and infection prevention and control for monkeypox.
13 Jun, 2022 | 10:49h | UTCRelated:
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
M-A: Respiratory viral co-infections in patients with COVID-19 and associated outcomes.
13 Jun, 2022 | 10:41h | UTC
NIH Updated Guideline: Oxygenation and ventilation for adults with Covid-19.
13 Jun, 2022 | 10:44h | UTCOxygenation and Ventilation for Adults – National Institutes of Health
RCT: Intramuscular tixagevimab–cilgavimab may benefit non-hospitalized unvaccinated adults with Covid-19.
13 Jun, 2022 | 10:39h | UTCCommentaries:
Safety and efficacy of tixagevimab–cilgavimab in preventing severe COVID – News Medical
Commentary on Twitter
NEW—A single intramuscular tixagevimab–cilgavimab dose provided protection against progression to severe COVID-19 or death vs placebo in unvaccinated individuals
TACKLE trial from Prof Hugh Montgomery & colleagues https://t.co/M9LENFsA2C pic.twitter.com/Aon4wJsBOi
— The Lancet Respiratory Medicine (@LancetRespirMed) June 8, 2022
Host-directed immunotherapy of viral and bacterial infections: past, present and future.
13 Jun, 2022 | 07:41h | UTCHost-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me
— Nature Portfolio (@NaturePortfolio) June 11, 2022
Another study suggests the Omicron variant is associated with a reduced risk of Multisystem Inflammatory Syndrome in Children compared to previous SARS-CoV-2 variants.
10 Jun, 2022 | 12:38h | UTCRelated study: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA AND Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP
Commentary on Twitter
Study found that the risk of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection during the #Omicron wave substantially lower compared to previous #SARSCoV2 variants. https://t.co/GYrz9XA72Z
— JAMA Pediatrics (@JAMAPediatrics) June 8, 2022
Cohort Study: Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy.
10 Jun, 2022 | 12:14h | UTCCommentaries:
Commentary on Twitter
This cohort study of #SARSCoV2 exposure in utero found preliminary evidence that maternal SARS-CoV-2 may be associated with neurodevelopmental sequelae in some offspring. https://t.co/dYdoJbNOdl
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
M-A: Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections.
10 Jun, 2022 | 12:00h | UTC
Guidance Statement: Surgical triage and timing for patients with COVID undergoing thoracic surgery.
10 Jun, 2022 | 11:58h | UTC
Review: Pathophysiology and mechanism of long COVID.
10 Jun, 2022 | 11:55h | UTCPathophysiology and mechanism of long COVID: a comprehensive review – Annals of Medicine
Guideline on management of diabetes-related foot infection.
10 Jun, 2022 | 11:51h | UTCRelated:
[Preprint] Largest study to date on long COVID identifies a broad list of diagnoses.
10 Jun, 2022 | 11:53h | UTCStudy Commentary: Largest study to date on long COVID identifies a broad list of diagnoses – News Medical
Commentary on Twitter
? The arguably largest #LongCovid study to date with millions of participants shows the increased risk of various symptoms after infection and the risk of having to take medications. https://t.co/DSvRcKVKIs pic.twitter.com/uUQxK1VQLv
— Jonas R. Kunst (@KunstJonas) May 23, 2022
RCT: Effect of point-of-care testing for respiratory pathogens on antibiotic use in children.
10 Jun, 2022 | 11:16h | UTC
Commentary on Twitter
In a randomized controlled trial of 1243 children, point-of-care testing for respiratory pathogens did not reduce antibiotic consumption in acutely ill children. https://t.co/KnD4zRx2bf
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
The global landscape of the burden of depressive symptoms/major depression in individuals living with HIV/AIDs and its effect on antiretroviral medication adherence.
10 Jun, 2022 | 10:31h | UTC
Sex differences in clinical characteristics, management strategies, and outcomes of STEMI With COVID-19.
9 Jun, 2022 | 11:24h | UTCEditorial: STEMIs and a Closer Look at MINOCA During the COVID-19 Pandemic – JSCAI
Video: Conversations in Interventional Cardiology: NACMI Registry
Commentary: Mystery MINOCA? Many COVID STEMIs Have No Culprit Lesion – TCTMD
Statement on initial antimicrobial treatment of sepsis.
8 Jun, 2022 | 11:17h | UTCStatement on initial antimicrobial treatment of sepsis – Faculty of Intensive Care Medicine
Commentary on Twitter
?Statement on initial antimicrobial treatment of sepsis?
Full statement and documents available➡️ https://t.co/jWexX1VDDd @AoMRC pic.twitter.com/kQdJrZ2hOA
— FICMNews (@FICMNews) June 4, 2022
Reducing SARS-CoV-2 in shared indoor air.
8 Jun, 2022 | 11:07h | UTCReducing SARS-CoV-2 in Shared Indoor Air – JAMA
M-A: Efficacy and harms of tocilizumab for the treatment of COVID-19 patients.
8 Jun, 2022 | 11:06h | UTC
M-A: Efficacy and safety of intensified versus standard prophylactic anticoagulation therapy in patients with Covid-19.
8 Jun, 2022 | 11:09h | UTCRelated:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
Commentary on Twitter
???Systematic review & meta-analysis @OFIDJournal Intensified anticoagulation has NO effect on mortality among hospitalised #COVID19 & ⬆️bleeding
Possible signal of mortality reduction for non-ICU patients although with low precision& high heterogeneity https://t.co/OqLYScxK53— Antibiotic Steward Bassam Ghanem?? (@ABsteward) June 7, 2022
Review: Timing of vasoactive agents and corticosteroid initiation in septic shock.
8 Jun, 2022 | 10:53h | UTCTiming of vasoactive agents and corticosteroid initiation in septic shock – Annals of Intensive Care
Combination anti-HIV antibody infusions suppress virus for prolonged period.
7 Jun, 2022 | 11:45h | UTCNews Release: Combination anti-HIV antibody infusions suppress virus for prolonged period – National Institutes of Health
Original Study: Combination anti-HIV antibodies provide sustained virological suppression – Nature
Commentaries on Twitter
Still don't get the enthusiasm for HIV Rx with bNAbs.
Compared to existing antivirals, they have:
– more baseline resistance
– the need to scale up new resistance tests
– more resource requirements (IV administration)
– … and, if like other monoclonals, $$$
What am I missing? https://t.co/7WZmIjutwE— Paul Sax (@PaulSaxMD) June 1, 2022
This is a wonderful advance.
"Our data demonstrate that combination therapy with broadly neutralizing monoclonal antibodies can provide long-term virological suppression without antiretroviral therapy in individuals with HIV"https://t.co/DKNVSlg3mC
— Michael Worobey (@MichaelWorobey) June 2, 2022
Prospective evaluation of autonomic dysfunction in patients with post-acute sequela of COVID-19.
7 Jun, 2022 | 11:38h | UTCCommentary: Autonomic Dysfunction in Post-Acute Sequela of COVID-19 – American College of Cardiology
Unintended consequences of measures implemented in the school setting to contain the COVID‐19 pandemic: a scoping review.
7 Jun, 2022 | 11:41h | UTCSummary: Unintended consequences of school-based measures to manage the COVID-19 pandemic – Cochrane Library
Prognostic indicators and outcomes of hospitalized COVID-19 patients with neurological disease: An individual patient data meta-analysis.
7 Jun, 2022 | 11:36h | UTC