RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.

Restriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay

Related:

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA

Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine

Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery – Critical Care

Commentary on Twitter

In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb pic.twitter.com/FtSaDIIroj

— NEJM (@NEJM) June 17, 2022