Covid-19
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients.
6 Aug, 2021 | 10:13h | UTC
Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.
6 Aug, 2021 | 10:09h | UTCMucormycosis after COVID-19 in a patient with diabetes – The Lancet
Related:
COVID-19 and mucormycosis superinfection: the perfect storm.
What is mucormycosis, the fungal infection affecting COVID patients in India?
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Global Guideline for the Diagnosis and Management of Mucormycosis
M-A: Chest radiograph findings in COVID-19.
6 Aug, 2021 | 10:03h | UTC
Review of COVID-19: Abdominal manifestations in adults and multisystem inflammatory syndrome in children.
6 Aug, 2021 | 10:05h | UTC
Fibrotic interstitial lung abnormalities at 1-year follow-up CT after severe COVID-19.
6 Aug, 2021 | 10:01h | UTCFibrotic Interstitial Lung Abnormalities at 1-year Follow-up CT after Severe COVID-19 – Radiology
Related: Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.
Commentary on Twitter
Data on 1 year outcomes for patients with post-COVID lung fibrosis. Small study, very little clinical information, including on treatment, and I object to the use of the term ILA, but overall not suggestive of progressive fibrotic lung disease. Thoughts?https://t.co/Kdt1pmTREl pic.twitter.com/mu1Jd2G6sd
— Anna Podolanczuk (@AnnaPodolanczuk) August 4, 2021
SARS-CoV-2 Variants in Patients with Immunosuppression.
5 Aug, 2021 | 09:02h | UTCSARS-CoV-2 Variants in Patients with Immunosuppression – New England Journal of Medicine
Commentary on Twitter
In the pandemic, immunocompromised people (~3% of Americans) are not getting adequate recognition for the potential of in-host evolution of the virus (highlighted studies) and the need for far better approaches to protect them https://t.co/XDT1VxC9ZK @NEJM pic.twitter.com/ciw1WD9EzC
— Eric Topol (@EricTopol) August 4, 2021
RCT: In noncritically ill patients hospitalized with Covid-19, therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge compared with usual-care thromboprophylaxis.
5 Aug, 2021 | 09:07h | UTCEditorial: Surviving Covid-19 with Heparin?
Commentaries:
Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD
Commentary on Twitter
In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. https://t.co/3JzKdmL3SB #IDTwitter pic.twitter.com/iDjSelp2HL
— NEJM (@NEJM) August 4, 2021
RCT: In critically ill patients with Covid-19, therapeutic anticoagulation with heparin did not result in improved outcomes compared to usual-care pharmacologic thromboprophylaxis.
5 Aug, 2021 | 09:04h | UTCEditorial: Surviving Covid-19 with Heparin?
Commentaries:
Therapeutic-Dose Heparin in COVID-19: Who Benefits, Who Doesn’t – TCTMD
Commentary on Twitter
Anticoagulation did not improve hospital survival in critically Ill patients with #COVID19. https://t.co/E8RXE01jbF pic.twitter.com/9idGxgbUas
— NEJM (@NEJM) August 4, 2021
RCT: Subcutaneous REGEN-COV antibody combination prevented symptomatic Covid-19 infection in previously uninfected household contacts of infected persons.
5 Aug, 2021 | 09:01h | UTCSubcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 – New England Journal of Medicine
Related:
Commentary on Twitter
Subcutaneous REGEN-COV prevented symptomatic #COVID19 and asymptomatic #SARSCoV2 infection in previously uninfected household contacts. https://t.co/rRNFTjS9hX pic.twitter.com/B7qXeyWKUb
— NEJM (@NEJM) August 4, 2021
Covid: WHO calls for booster pause to vaccinate poorer nations.
5 Aug, 2021 | 08:59h | UTCCovid: WHO calls for booster pause to vaccinate poorer nations – BBC
See also:
Why WHO Is Calling For A Moratorium On COVID Vaccine Boosters – NPR
WHO calls for moratorium on COVID-19 boosters – CIDRAP
WHO asks wealthy nations to hold off on Covid vaccine boosters at least through September – CNBC
WHO calls for a temporary moratorium on administering booster shots of Covid-19 vaccines – STAT
Commentary on Twitter (thread – click for more)
NEW—The World Health Organization called for a moratorium on coronavirus booster vaccinations until the end of September, so that vaccine supplies can be focused on helping less wealthy countries to vaccinate at least ten percent of their populations,https://t.co/fwBl28fjWn
— Eric Feigl-Ding (@DrEricDing) August 4, 2021
Myocarditis and pericarditis after vaccination for COVID-19.
5 Aug, 2021 | 08:57h | UTCMyocarditis and Pericarditis After Vaccination for COVID-19 – JAMA
Related:
Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.
Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
5 Aug, 2021 | 08:55h | UTCSee guidance: ASA and APSF Statement on Perioperative Testing for the COVID-19 Virus
Related:
Position statement: Perioperative management of post-COVID-19 surgical patients.
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
Opinion: Watch the U.K. to Understand Delta – “The country lifted all its COVID-19 restrictions just as Delta peaked. What happens next will tell us how well vaccines are working.”
5 Aug, 2021 | 08:52h | UTCWatch the U.K. to Understand Delta – The Atlantic
Coronavirus infections three times lower in double vaccinated people – REACT.
5 Aug, 2021 | 08:53h | UTC
Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”
4 Aug, 2021 | 10:06h | UTCInvited commentary: Citizen science and biomedical research (free registration required)
Commentaries:
Long Covid uncommon in children, analysis finds – King’s College London
Study finds long-term Covid symptoms rare in school-age children – The Guardian
Related:
Cohort study: Risk factors for long covid in previously hospitalized children.
Commentary on Twitter
New @LancetChildAdol is a very reassuring prospective study of >250,000 children, >1700 with + covid test, age 5-17, that shows the risk for chronic Covid symptoms is quite low; 4.4% beyond 4 weekshttps://t.co/XVFs0UtHWC pic.twitter.com/XBVH5wmFve
— Eric Topol (@EricTopol) August 3, 2021
AAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.
4 Aug, 2021 | 10:03h | UTC
Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”
4 Aug, 2021 | 09:53h | UTCThe Delta Surge May Collapse Faster Than You Think – ZDoggMD
Related:
The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.
How the coronavirus infects cells — and why Delta is so dangerous.
CDC changes mask guidance in response to threat of Delta variant of Covid-19.
Position statement: Perioperative management of post-COVID-19 surgical patients.
4 Aug, 2021 | 10:00h | UTCRelated:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
Commentary on Twitter
Interesting position statement (from India) for perioperative management of post-COVID-19 surgical patients. Highlights important points to consider but appears overly cautious, recommending a lot of preop testing. #COVID19 https://t.co/oOR1ik21ha
— Steven Cohn, MD (@preopconsult) August 3, 2021
AAP Guidance: Post-COVID-19 conditions in children and adolescents.
4 Aug, 2021 | 10:01h | UTCPost-COVID-19 Conditions in Children and Adolescents – American Academy of Pediatrics
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.
4 Aug, 2021 | 09:55h | UTCRelated:
Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter (thread – click for more)
Excess mortality across the world with the World Mortality Dataset – officially published at @eLife!https://t.co/bCudrKhZ6d
A thread on data, findings, and more.
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(Illustration by Gal Kabiri) pic.twitter.com/oqtXRqUQH9
— Ariel Karlinsky (@ArielKarlinsky) August 3, 2021
Antimicrobial stewardship in the ICU in COVID times: the known unknowns.
4 Aug, 2021 | 09:16h | UTCRelated:
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?
Too many COVID-19 patients get unneeded ‘just in case’ antibiotics
RCT: Text-message reminders can increase COVID-19 vaccinations.
4 Aug, 2021 | 09:12h | UTCBehavioral Nudges Increase COVID-19 Vaccinations – Nature
Commentaries:
Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA
Text reminders boost vaccine appointments – Carnegie Mellon University
Commentary on Twitter
Sometimes the tools that actually work in public health are profoundly boring. Here, a text message reminder system is shown in a randomized trial to increase vaccine uptake. Years of HIV adherence research has shown the value of simple nudges like this.https://t.co/1ndpnQ6Ha6 https://t.co/Gltll8DTJ4
— Natalie E. Dean, PhD (@nataliexdean) August 3, 2021
Spontaneous pneumomediastinum in patients diagnosed with covid-19: a case series with review of literature.
4 Aug, 2021 | 09:13h | UTC
How much worse can the coronavirus get?
4 Aug, 2021 | 09:09h | UTCHow much worse can the coronavirus get? – Vox
M-A: Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease.
3 Aug, 2021 | 09:09h | UTC