Covid-19
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
12 Aug, 2021 | 09:05h | UTCCommentary: Largest Study of VITT After COVID-19 Vaccination Digs Into Lab, Clinical Features – TCTMD
Related:
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
The phenotypes of VITT were defined in 220 patients presenting a 14-day median after the first ChAdOx1 nCoV-19 dose. Mortality was 22%. https://t.co/ir0yG5X0BP #COVID19 #IDTwitter pic.twitter.com/iAfxs0I1Ce
— NEJM (@NEJM) August 11, 2021
M-A: Asymptomatic SARS-CoV-2 infection – “we estimate that the percentage of infections that never developed clinical symptoms, and thus were truly asymptomatic, was 35.1%”.
11 Aug, 2021 | 08:49h | UTC
Commentary on Twitter
The best comprehensive review of the asymptomatic status with Covid, >350 studies, just out @PNASNews https://t.co/xyfgyGXANL
Overall: true, never had symptoms 35%; children 47%@Pratha_Sah @Alison_Galvani @MeaganCFitz @YaleSPH & colleagues
(wonder what the rate is w/ Delta) pic.twitter.com/9W6wbvQno6— Eric Topol (@EricTopol) August 10, 2021
PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.
11 Aug, 2021 | 08:52h | UTCInvited Commentary: The use of inhaled corticosteroids in early-stage COVID-19
WHO Guidance for surveillance of SARS-CoV-2 variants.
11 Aug, 2021 | 08:50h | UTC
Commentary on Twitter (thread – click for more)
🆕 WHO guidance for national surveillance of #COVID19 virus variants 👉https://t.co/YHRsazZhPA
Standardizing the monitoring & reporting of the variants will give us a better understanding of the virus at a global scale. pic.twitter.com/VNcxv8gyaa
— World Health Organization (WHO) (@WHO) August 10, 2021
M-A: More than 50 long-term effects of COVID-19.
11 Aug, 2021 | 08:47h | UTCRelated:
Cohort study: Risk factors for long covid in previously hospitalized children.
Viewpoint: The road to addressing Long Covid.
Review: Long covid—mechanisms, risk factors, and management.
Review: Symptoms, complications and management of long COVID.
Studies elucidate poorly understood long COVID.
Long Covid: Half of young adults with COVID-19 have persistent symptoms 6 months after, study finds.
[Preprint] Long Covid: Third of people infected have long term symptoms.
Almost 25% of COVID-19 patients develop long-lasting symptoms, according to a new report.
Perspective | The four most urgent questions about long COVID.
Systematic review: Frequency, signs and symptoms, and criteria adopted for long COVID-19.
Report: 376,000 people in UK have had long Covid symptoms for at least a year.
One third of patients hospitalized with COVID-19 have lung changes after a year
Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.
Cohort study: One in ten have long-term effects 8 months following mild COVID-19
Long Covid Implications for the workplace
Long Covid in the UK – More than a million affected in February, survey suggests
Covid-19: Middle aged women face greater risk of debilitating long term symptoms
Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”
Review | Post-acute COVID-19 syndrome
Long Covid | Four-month clinical status of a cohort of patients after hospitalization for COVID-19
Perspective | Long Covid isn’t as unique as we thought
Attributes and predictors of long COVID
WHO Report: Preparing for Long COVID 2021
Long Covid: Sequelae in adults at 6 Months after COVID-19 infection
How many people get ‘long COVID’ – and who is most at risk?
Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline
Patients, clinicians seek answers to the mystery of ‘Long COVID’
Long Covid: 6-month consequences of COVID-19 in patients discharged from hospital
NICE Guideline: Managing the long-term effects of COVID-19
Commentary on Twitter
https://twitter.com/svillapol/status/1425032774793285648
Opinion | We should not dismiss the possibility of eradicating COVID-19: comparisons with smallpox and polio.
11 Aug, 2021 | 08:42h | UTC
CDC Report: COVID-19 morbidity and mortality far exceed the potential risks of rare side effects caused by vaccines.
11 Aug, 2021 | 08:45h | UTC
Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.
11 Aug, 2021 | 08:44h | UTCRelated:
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
https://twitter.com/JohnGRizk/status/1425126093288353800
M-A: Child and youth mental health problems have doubled during COVID-19.
10 Aug, 2021 | 10:03h | UTCCommentary: Child and youth mental health problems have doubled during COVID-19 – The Conversation
Original study: Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis – JAMA Pediatrics
Editorial: Addressing the Global Crisis of Child and Adolescent Mental Health – JAMA Pediatrics
Related:
More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.
COVID has caused ‘mass trauma,’ worsening mental health globally.
COVID’s mental-health toll: how scientists are tracking a surge in depression
WHO: COVID-19 disrupting mental health services in most countries
Commentary on Twitter (thread – click for more)
Many are rightfully sounding the alarm to a youth #mentalhealth crisis. Our meta-analysis of 29 studies w >80,000 youth worldwide in @JAMAPediatrics, shows 1 in 4 youth had elevated depression or anxiety during #COVID19. A thread 🧵 https://t.co/etIdZTHnme
— Dr. Sheri Madigan (she/her) (@sherimadigan) August 9, 2021
[Preprint] Phase 1/2 RCT: A booster dose is immunogenic and will be needed for older adults who have completed two doses vaccination with CoronaVac.
10 Aug, 2021 | 09:58h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1424644994120372224
Viral load of SARS-CoV-2 in respiratory aerosols emitted by COVID-19 patients while breathing, talking, and singing.
10 Aug, 2021 | 10:02h | UTC
Commentary on Twitter
Our peer-reviewed research is now published in Clinical Infectious Diseases! No matter how you slice it, COVID-19 is an airborne disease. Let's call it like it is and put the appropriate measures in place.https://t.co/R4MeIlwBY6
— Kristen K. Coleman (@drkristenkc) August 7, 2021
A WHO expert explains why she believes the rush for Covid-19 boosters is premature.
10 Aug, 2021 | 09:56h | UTCA WHO expert explains why she believes the rush for Covid-19 boosters is premature – STAT
Commentary on Twitter
Must read interview on rich nations rushing into booster doses
Dr @Kate_L_OBrien by @HelenBranswell @statnews
"We really have huge inequity right now in just getting primary doses to people. Does a third dose need to be given?"https://t.co/pRhYwINuKf pic.twitter.com/YQS6Nj0Hyi
— Madhu Pai, MD, PhD (@paimadhu) August 9, 2021
Covid-19: How effective are vaccines against the delta variant?
10 Aug, 2021 | 10:00h | UTCCovid-19: How effective are vaccines against the delta variant? – The BMJ
A giant trial of COVID-19 treatments organized by the WHO is restarting. Here are the drugs it’s betting on.
10 Aug, 2021 | 09:52h | UTCA giant trial of COVID-19 treatments is restarting. Here are the drugs it’s betting on – Science
Related: WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Study ties COVID vaccines to lower transmission rates.
10 Aug, 2021 | 09:51h | UTCStudy ties COVID vaccines to lower transmission rates – CIDRAP
‘Breakthrough’ infections do not mean COVID vaccines are failing.
10 Aug, 2021 | 09:54h | UTC‘Breakthrough’ Infections Do Not Mean COVID Vaccines Are Failing – Scientific American
Commentary on Twitter
https://twitter.com/laurahelmuth/status/1422897892797337609
Interactive infographic: Data shows how rare severe breakthrough Covid infections are.
9 Aug, 2021 | 00:01h | UTCData shows how rare severe breakthrough Covid infections are – NBC News
Commentary on Twitter
Very good interactive infographic for impact of vaccination in 2021 by state https://t.co/HAfYYPX9FI by @NBCNews @seenigel @ChicagoEl @pdrbarquinha @jiachuanwu @NBCNewsGraphics
Here for California: Hospitalizations, deaths and infections pic.twitter.com/83Hxl2x2gm— Eric Topol (@EricTopol) August 7, 2021
RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.
9 Aug, 2021 | 00:06h | UTCInvited commentary: Optimising SARS-CoV-2 vaccination schedules – The Lancet
Related: Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)
Commentary on Twitter
Just published @TheLancet
A randomized mix and match trial of AZ and Pfizer vaccination in >800 people shows that mixing is safe and can engender at least as good, if not better, immune response https://t.co/V40Dy59Ia8 by @XinxueLiu and colleagues pic.twitter.com/tKl59LFz4i— Eric Topol (@EricTopol) August 6, 2021
COVID: WHO calls for moratorium on booster shots – is it justifiable?
8 Aug, 2021 | 23:54h | UTCCOVID: WHO calls for moratorium on booster shots – is it justifiable? – The Conversation
Related: Covid: WHO calls for booster pause to vaccinate poorer nations.
Commentary on Twitter
The authors put it well: Even if affluent countries prioritize boosters for the vulnerable, 'the degree of additional benefit…is uncertain.' Yet we know 'vaccines could do a huge amount of good for the large number of vulnerable ppl who've not yet received a single dose.' https://t.co/6qNV6pzDDk
— Tedros Adhanom Ghebreyesus (@DrTedros) August 7, 2021
CDC study showed a reduced risk of reinfection with SARS-CoV-2 after covid-19 vaccination.
9 Aug, 2021 | 00:03h | UTC
Commentaries on Twitter
This is non randomized. The two biases are:
1. Behavior among those who got vaccinated likely different than those who don't
2. Likely those who didn't tested more aggressively
I would not cite this as many are doinghttps://t.co/rSkBC37uq0
— Vinay Prasad MD MPH (@VPrasadMDMPH) August 7, 2021
Study shows that full #COVIDVaccination ⬇️ likelihood of being re-infected with #COVID19 compared to those who were previously had COVID but were not vaccinated (risk ⬆️ 2.3 fold)#GetVaccinated even if you have had COVID previouslyhttps://t.co/3dF3XPxwYp
@fascinatorfun pic.twitter.com/ip6zTvNN86
— Prof Kamlesh Khunti (@kamleshkhunti) August 7, 2021
M-A: SARS-CoV-2 Setting-specific transmission rates – “Households showed the highest transmission rates, with a pooled secondary attack rates of 21.1%”.
8 Aug, 2021 | 23:57h | UTC
Commentary on Twitter
SARS-CoV-2 setting-specific transmission rates: a systematic review and meta-analysis
Households highest transmission rates, pooled SAR~21.1%. Contacts at social events~5.9%. Workplaces~1.9%. Age gradient for transmission potential in h/hold context. https://t.co/m27kkDrTgy
— Andrew Lee is heading to @andrewleedr.bsky.social (@andrewleedr) March 10, 2021
COVID vaccine boosters: the most important questions.
8 Aug, 2021 | 23:52h | UTCCOVID vaccine boosters: the most important questions – Nature
Commentary on Twitter
I agree with @nataliexdean: “We just don’t have clear evidence of enough of a loss of efficacy to change our focus or distract from the main goal, which is trying to get as many people first doses” as possible." https://t.co/FEKB4vg0Dz
— Sanghyuk Shin (@sanghyuk_shin) August 6, 2021
Tokyo feared Games would spread COVID; numbers suggest that didn’t happen.
8 Aug, 2021 | 23:56h | UTCTokyo feared Games would spread COVID; numbers suggest that didn’t happen – Reuters
Commentary on Twitter
Before the #Olympics began, Japan feared that the Games might spread COVID-19, introduce new variants and overwhelm the medical system. The infection numbers from inside the Olympic 'bubble' tell a different story https://t.co/EsIxj3gsNx
— Reuters (@Reuters) August 7, 2021
More data showing one dose of Pfizer vaccine may be enough for individuals who’ve had COVID.
8 Aug, 2021 | 23:50h | UTCCommentary: One Dose of Pfizer Vaccine May Be Enough for Folks Who’ve Had COVID – HealthDay
Related:
Perspective | Is one vaccine dose enough if you’ve had COVID? What the science says.
Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Spain to give just one vaccine dose to under 55-year olds who had COVID-19
Perspective: Is one vaccine dose enough after COVID-19 infection?
France’s health authority recommends single vaccine shot for people who have had COVID-19
Covid-19: People who have had infection might only need one dose of mRNA vaccine
Commentary on Twitter
SARS-CoV-2 Antibody Responses After 1 and 2 Doses of the BNT162b2 Vaccine https://t.co/ARMdH8Yboo via @JAMANetworkOpen part of @JAMANetwork Small study but one that confirms the policy of many European countries in which one dose of vaccine is sufficient after having COVID.
— Carlos del Rio (@CarlosdelRio7) August 7, 2021
Case report: Systemic capillary leak syndrome after ChAdOx1 nCOV-19 (Oxford–AstraZeneca) vaccination.
8 Aug, 2021 | 23:49h | UTC