Covid-19
RCT: Oral Nirmatrelvir for high-risk adults with Covid-19 reduces the risk of hospitalization by 89%.
17 Feb, 2022 | 10:14h | UTCAudio Interview: A New Antiviral against Covid-19 – new England Journal of Medicine
Related:
Commentary on Twitter
The Paxlovid pill (Nirmatrelvir) randomized, placebo-controlled trial published @NEJM:
89% efficacy vs Covid hospitalizations or deaths, and quick reduction of viral load.
The active pills had less serious adverse events or discontinuations than placebohttps://t.co/HBMRZt4wBo pic.twitter.com/LDQv41O56c— Eric Topol (@EricTopol) February 16, 2022
Retrospective cohort study: Pfizer vaccine reduces the risk of reinfection after recovery from Covid-19.
17 Feb, 2022 | 10:13h | UTCEffectiveness of the BNT162b2 Vaccine after Recovery from Covid-19 – New England Journal of Medicine
Commentary on Twitter
Among patients who had recovered from Covid-19, the receipt of at least one dose of the BNT162b2 vaccine was associated with a significantly lower risk of recurrent infection. https://t.co/AAlsY9sFlv pic.twitter.com/Nkj1lP77ZW
— NEJM (@NEJM) February 16, 2022
England to offer Covid jab to five to 11-year-olds.
17 Feb, 2022 | 10:09h | UTCEngland to offer Covid jab to five to 11-year-olds – BBC
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.
17 Feb, 2022 | 09:58h | UTCCommentary: Studies detail risk of severe COVID-19, GI problems in kids – CIDRAP
Commentary on Twitter
The risk of intensive care unit admission among children with COVID-19 is affected by age, ethnicity and comorbidities, according to a @NatureMedicine paper. Understanding these modifiers might help identify at-risk children and guide interventions. https://t.co/MIkLecyNI6 pic.twitter.com/JtN3Ab4Lu7
— Nature Portfolio (@NaturePortfolio) December 20, 2021
How COVID-19 transformed genomics and changed the handling of disease outbreaks forever.
17 Feb, 2022 | 09:56h | UTC
Review | Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic.
17 Feb, 2022 | 09:54h | UTCRelated:
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.
CDC unveils its latest weapon in Covid-19 detection: wastewater.
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
The myriad ways sewage surveillance is helping fight COVID around the world – Nature
It’s time to begin a national wastewater testing program for Covid-19 – STAT
Coronavirus: Testing sewage an ‘easy win’ – BBC
SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.
17 Feb, 2022 | 10:01h | UTCRelated:
Response to additional COVID-19 vaccine doses in people who are immunocompromised: a rapid review.
16 Feb, 2022 | 10:13h | UTC
Commentary on Twitter
A review of the 23 studies of Covid vaccination for immunocompromised people indicates the level of responders varies with conditions. Even additional doses may not provide sufficient protection for some, requiring additional measureshttps://t.co/BjaKrJUAbO @LancetGH pic.twitter.com/EYVWAX23Ig
— Eric Topol (@EricTopol) February 15, 2022
WHO Interim Guidance: Public health surveillance for COVID-19.
16 Feb, 2022 | 10:08h | UTCPublic health surveillance for COVID-19: interim guidance – World Health Organization
2021 Year in Review in 11 Charts: The Inequality Pandemic.
16 Feb, 2022 | 09:55h | UTC2021 Year in Review in 11 Charts: The Inequality Pandemic – The World Bank
Commentary on Twitter
The impact of the #COVID19 pandemic is largest for the world’s poorest. Vulnerable groups, including women, workers with low education, and those informally employed in urban areas, were hit particularly hard.
Read more in our #YearInReview: https://t.co/biyED5aJ5l pic.twitter.com/g7jTZIjm96— World Bank (@WorldBank) February 1, 2022
COVID: China is developing its own mRNA vaccine – and it’s showing early promise.
16 Feb, 2022 | 09:56h | UTCCOVID: China is developing its own mRNA vaccine – and it’s showing early promise – The Conversation
WHO Questions and Answers: COVID-19 vaccines and pregnancy.
16 Feb, 2022 | 09:53h | UTCQuestions and Answers: COVID-19 vaccines and pregnancy – World Health Organization
Related:
COVID vaccines safely protect pregnant people: the data are in.
COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
? Summary of WHO recommendations on #COVID19 vaccination in pregnancy https://t.co/XPVggBbSmj
If you’re pregnant, vaccination is one of the most important ways to protect yourself and your baby from severe illness from COVID-19. pic.twitter.com/dfSBVJLBG7
— World Health Organization (WHO) (@WHO) February 15, 2022
Covid-19: Vaccination during pregnancy is safe, finds large US study.
16 Feb, 2022 | 09:51h | UTCCovid-19: Vaccination during pregnancy is safe, finds large US study – The BMJ
Related:
COVID vaccines safely protect pregnant people: the data are in.
COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
ACR Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19.
15 Feb, 2022 | 10:17h | UTCCommentary and summary: ACR Updates Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With COVID – RheumNow
Why don’t most people with COVID need to test for another 30 days, even if they’re re-exposed?
15 Feb, 2022 | 10:14h | UTC
Essay: Tuberculosis in times of COVID-19.
15 Feb, 2022 | 10:16h | UTCTuberculosis in times of COVID-19 – Journal of Epidemiology & Community Health
Related:
Covid-19’s Devastating Effect on Tuberculosis Care — A Path to Recovery.
Global tuberculosis progress reversed by COVID-19 pandemic.
How COVID is derailing the fight against HIV, TB and malaria.
How COVID hurt the fight against other dangerous diseases
World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis
Tuberculosis and Covid-19: Fighting a deadly syndemic
Omicron-targeted vaccines do no better than original jabs in early tests in animals.
15 Feb, 2022 | 10:09h | UTCOmicron-targeted vaccines do no better than original jabs in early tests – Nature
Retrospective Cohort: Association of SARS-CoV-2 infection with serious maternal morbidity and mortality from obstetric complications.
15 Feb, 2022 | 10:11h | UTCNews Release: NIH-funded study suggests COVID-19 increases risk of pregnancy complications – NIH News Releases
Commentary on Twitter
In this study, among pregnant and postpartum individuals, #SARSCoV2 infection was associated with increased risk of a composite outcome of maternal mortality or serious morbidity from obstetric complications. https://t.co/51wcT8GhJq
— JAMA (@JAMA_current) February 7, 2022
Scientists deliberately gave people COVID — here’s what they learnt.
15 Feb, 2022 | 10:06h | UTCScientists deliberately gave people COVID — here’s what they learnt – Nature
Original Study: [Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).
Related:
World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject)
Meta-analysis of randomized clinical trials: vaccines to prevent COVID-19.
15 Feb, 2022 | 10:04h | UTC
Systematic Review: Efficacy of antiviral therapies for COVID-19.
15 Feb, 2022 | 10:02h | UTC
Study identifies risk factors for severe CoviD-19 in children.
15 Feb, 2022 | 10:01h | UTCRisk Factors for Severe COVID-19 in Children – Pediatrics
Covid-19: Fourth vaccine doses—who needs them and why?
15 Feb, 2022 | 09:59h | UTCCovid-19: Fourth vaccine doses—who needs them and why? – The BMJ
Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in children under 5.
13 Feb, 2022 | 22:51h | UTCPfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in young children – STAT
See also:
COVID-19 vaccine for kids under 5 delayed as Pfizer extends trial – CIDRAP
Pfizer postpones FDA request for Covid vaccine for kids under 5 – NBC News
Novavax says protein vaccine works for kids as young as 12.
13 Feb, 2022 | 22:54h | UTCNovavax says protein vaccine works for kids as young as 12 – Associated Press
Press Release: Novavax Announces Positive Results of COVID-19 Vaccine in Pediatric Population of PREVENT-19 Phase 3 Clinical Trial
Related:
Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.
RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.
New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work
Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant