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Antibiotic Stewardship

Patients labeled as nonallergic after initial tests for penicillin allergy may develop resensitization afterwards

2 Feb, 2023 | 15:03h | UTC

Resensitization in suspected penicillin allergy – Allergy

Video summary: Resensitisation in suspected penicillin allergy

Commentary: Patients should be retested for penicillin resensitization before being deemed nonallergic – Healio (free registration required)

Related:

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs – JAC-Antimicrobial Resistance

Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC) – Journal of Investigational Allergology and Clinical Immunology (PDF)

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

Deconstructing the dogma: meta-analysis of adjunctive gentamicin and rifampin in staphylococcal prosthetic valve endocarditis

2 Feb, 2023 | 15:00h | UTC

Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Fungal Nomenclature: managing change is the name of the game

2 Feb, 2023 | 14:59h | UTC

Fungal Nomenclature: Managing Change is the Name of the Game – Open Forum Infectious Diseases

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/thefunguskidd/status/1611639451134070784

 

A primer on home infusion administration methods

2 Feb, 2023 | 14:57h | UTC

A Primer on Home Infusion Administration Methods – Open Forum Infectious Diseases

 

M-A | Diagnostic value of bronchoalveolar lavage fluid galactomannan assay for invasive pulmonary aspergillosis

2 Feb, 2023 | 14:50h | UTC

Diagnostic value of bronchoalveolar lavage fluid galactomannan assay for invasive pulmonary aspergillosis in adults: A meta-analysis – Journal of Clinical Pharmacy and Therapeutics

 

RCT | Oral minocycline plus rifampicin vs. oral linezolid for complicated skin and skin structure infections caused by MRSA

2 Feb, 2023 | 14:33h | UTC

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial – eClinicalMedicine

 

Recommendations for non-HIV associated cryptococcal meningoencephalitis

1 Feb, 2023 | 13:20h | UTC

Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome – Frontiers in Neurology

 

Case Report | Novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium

1 Feb, 2023 | 13:13h | UTC

Novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium – Sexually Transmitted Infections

News Release: Common eye infection antibiotic may clear up treatment-resistant STI – BMJ Newsroom

 

Syphilis in dermatology: recognition and management

31 Jan, 2023 | 14:01h | UTC

Syphilis in Dermatology: Recognition and Management – American Journal of Clinical Dermatology (if the link is paywalled, try this one in PMC)

 

Cohort Study | Severe lymphopenia may predict worse outcomes in hospitalized patients with pneumococcal CAP

31 Jan, 2023 | 13:52h | UTC

Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia – Infection (if the link is paywalled, try this one in PMC)

 

Review | Skin infections due to Panton-Valentine Leukocidin–producing S. aureus

31 Jan, 2023 | 13:44h | UTC

Skin Infections Due to Panton-Valentine Leukocidin–Producing S. Aureus – Deutsches Ärzteblatt international

 

M-A | Vancomycin area under the curve vs. trough only guided dosing and the risk of acute kidney injury

31 Jan, 2023 | 13:32h | UTC

Vancomycin area under the curve versus trough only guided dosing and the risk of acute kidney injury: Systematic review and meta-analysis – Pharmacology

 

Review | The blood–brain barrier and optimization of antibiotics for the treatment of CNS infections in adults

27 Jan, 2023 | 11:55h | UTC

The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults – Antibiotics

 

RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis

24 Jan, 2023 | 14:33h | UTC

2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP

 

Commentary on Twitter

https://twitter.com/TheLancet/status/1615998251945050112

 

ASCO Guideline | Management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients

24 Jan, 2023 | 14:28h | UTC

Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update – Journal of Clinical Oncology

 

Recommendations for the diagnosis and management of COVID-19 associated bacterial and fungal infections

20 Jan, 2023 | 14:48h | UTC

Recommendations and guidelines for the diagnosis and management of Coronavirus Disease-19 (COVID-19) associated bacterial and fungal infections in Taiwan – Journal of Microbiology, Immunology and Infection

 

RCT | Aqueous povidone-iodine vs. normal saline for intraoperative wound irrigation on the incidence of SSI after GI surgery

19 Jan, 2023 | 13:54h | UTC

Aqueous Povidone-Iodine Versus Normal Saline For Intraoperative Wound Irrigation On The Incidence Of Surgical Site Infection In Clean-Contaminated Wounds After Gastroenterological Surgery: A Single Institute, Prospective, Blinded-Endpoint, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 

Review | Surgical site infection prevention

18 Jan, 2023 | 14:31h | UTC

Surgical Site Infection Prevention: A Review – JAMA (free for a limited period)

Author interview: Surgical Site Infection Prevention – JAMA

Related:

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery 

Global guidelines on the prevention of surgical site infection – World Health Organization 

Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence 

APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control

Perioperative care bundles for the prevention of surgical-site infections: meta-analysis – British Journal of Surgery

AAOS Guideline: Prevention of surgical site infections after major extremity trauma.

 

Consensus statement | Use of a 4-month treatment regimen for drug susceptible TB in children with uncomplicated disease

18 Jan, 2023 | 14:25h | UTC

Consensus statement on the use of a four-month treatment regimen for drug susceptible tuberculosis in children (< 10 years of age) with uncomplicated disease – Australian Government Department of Health and Aged Care

 

SR | Pre‐emptive antifungal therapy vs. empirical antifungal therapy for febrile neutropenia in people with cancer

18 Jan, 2023 | 14:18h | UTC

Pre‐emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer – Cochrane Library

Summary: Pre-emptive versus empirical antifungal therapy in people with cancer who have febrile neutropenia – Cochrane Library

 

SHEA statement on antibiotic stewardship in hospitals during public health emergencies

17 Jan, 2023 | 13:18h | UTC

SHEA statement on antibiotic stewardship in hospitals during public health emergencies – Infection Control & Hospital Epidemiology 

 

Review | Viral infections in critical care

17 Jan, 2023 | 13:01h | UTC

Viral infections in critical care: a narrative review – Anaesthesia

 

M-A | Colonisation with ESCR-Enterobacterales and infection risk in surgical patients

17 Jan, 2023 | 12:58h | UTC

Colonisation with Extended-Spectrum Cephalosporin-Resistant Enterobacterales and Infection Risk in Surgical Patients: A Systematic Review and Meta-analysis – Infectious Diseases and Therapy

 

Best infectious diseases articles from 2022 – A year end review of non-COVID literature

15 Jan, 2023 | 20:31h | UTC

Best Infectious Diseases Articles From 2022 – A Year End Review Of Non-COVID Literature – IDstewardship

 

Commentary on Twitter

 

RCT | Colistin monotherapy vs. combination therapy for carbapenem-resistant organisms

13 Jan, 2023 | 13:36h | UTC

Colistin Monotherapy versus Combination Therapy for Carbapenem-Resistant Organisms – NEJM Evidence

Commentary: Colistin Alone or with Meropenem: Is More Better? – NEJM Journal Watch

Related: Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial – The Lancet

 

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