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Antibiotic Stewardship

Study suggests delivering high concentrations of antibiotics into the implantation site is feasible for infections in implanted CV electronic devices

13 Jan, 2023 | 13:26h | UTC

Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: 

Direct Delivery of Antibiotics to CV Device Pocket Infections Appears Promising – TCTMD

Regional Antibiotics for Implanted Cardiovascular Electronic Device Infections – American College of Cardiology

 

Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease

13 Jan, 2023 | 13:25h | UTC

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study – Gut

News Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom

Commentaries: 

Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP

Antibiotic Exposure Positively Linked to IBD Development – HealthDay

 

Commentary on Twitter

 

RCT | Second-line levofloxacin-based quadruple therapy vs. bismuth-based quadruple therapy for Helicobacter pylori eradication

12 Jan, 2023 | 13:06h | UTC

Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

SR | Interventions for the eradication of methicillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis

12 Jan, 2023 | 13:04h | UTC

Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis – Cochrane Library

 

Review | Early diagnosis and prevention of infections in cirrhosis

12 Jan, 2023 | 12:47h | UTC

Early Diagnosis and Prevention of Infections in Cirrhosis – Seminars in Liver Disease

 

RCT | Efficacy and safety of azithromycin vs. placebo to treat lower respiratory tract infections associated with low procalcitonin.

16 Dec, 2022 | 13:30h | UTC

Efficacy and safety of azithromycin versus placebo to treat lower respiratory tract infections associated with low procalcitonin: a randomised, placebo-controlled, double-blind, non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text) 

Commentary: Study Evaluates Biomarker to Help Curb Unnecessary Antibiotic Use: Placebo Worse Than Antibiotics After 5 Days, But Similar at Day 11 – Duke Health

 

Commentary on Twitter

 

SR | Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.

14 Dec, 2022 | 14:51h | UTC

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins – Cochrane Library

 

Prevention of device-related infections in patients with cancer: Current practice and future horizons.

13 Dec, 2022 | 14:30h | UTC

Prevention of device-related infections in patients with cancer: Current practice and future horizons – CA: A Cancer Journal for Clinicians

 

WHO Report signals increasing resistance to antibiotics in bacterial infections in humans.

12 Dec, 2022 | 12:52h | UTC

News Release: Report signals increasing resistance to antibiotics in bacterial infections in humans and need for better data – World Health Organization

Report: Global antimicrobial resistance and use surveillance system (‎GLASS)‎ report: 2022 – World Health Organization

Commentary: WHO report shows rising antibiotic resistance, need for better data – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

Approach to fever in patients with neutropenia: a review of diagnosis and management.

8 Dec, 2022 | 12:44h | UTC

Approach to fever in patients with neutropenia: a review of diagnosis and management – Therapeutic Advances in Infectious Disease

Related:

The Dutch Working Party on Antibiotic Policy (SWAB) Recommendations for the Diagnosis and Management of Febrile Neutropenia in Patients with Cancer – Infectious Diseases and Therapy

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO) – Annals of Hematology

SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology

Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

 

Podcast | Procalcitonin revisited.

7 Dec, 2022 | 14:17h | UTC

Annals On Call – Procalcitonin Revisited – Annals of Internal Medicine

 

RCT | Efficacy of postoperative oral cephalexin and metronidazole on SSI in obese women undergoing cesarean section.

7 Dec, 2022 | 14:13h | UTC

Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III – Antimicrobial Resistance & Infection Control

 

Redefining Staphylococcus aureus bacteremia: a structured approach guiding diagnostic and therapeutic management.

5 Dec, 2022 | 00:20h | UTC

Redefining Staphylococcus aureus bacteremia: A structured approach guiding diagnostic and therapeutic management – Journal of Infection

 

Commentary on Twitter

https://twitter.com/ABsteward/status/1594800589464293376

Under a Creative Commons Attribution (CC BY 4.0) license

Perspective | Push to use antibiotics to prevent sexually transmitted infections raises concerns.

2 Dec, 2022 | 14:27h | UTC

Push to use antibiotics to prevent sexually transmitted infections raises concerns – Nature

Related: [News release – not published yet] RCT: Doxycycline after unprotected sex significantly reduced STIs – study of men who have sex with men and transgender women stopped early for effectiveness.

 

German guideline on diverticular disease/diverticulitis.

30 Nov, 2022 | 13:41h | UTC

German guideline diverticular disease/diverticulitis: Part I: Methods, pathogenesis, epidemiology, clinical characteristics (definitions), natural course, diagnosis and classification – UEG Journal

Editorial: New German guidelines for the management of diverticulitis – UEG Journal

Related:

Systematic Review: Antibiotics for uncomplicated diverticulitis.

Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)

The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly – World Journal of Emergency Surgery

Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine

Changing Paradigms in the Management of Acute Uncomplicated Diverticulitis – Scandinavian Journal of Surgery

Elective surgical management of diverticulitis – Current Problems in Surgery

Management of Colonic Diverticulitis – Agency for Healthcare Research and Quality

2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting – World Journal of Emergency Surgery

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis – Diseases of the Colon & Rectum

 

Liposomal amphotericin B — Past, present and future.

29 Nov, 2022 | 14:03h | UTC

Foreword

Liposomal amphotericin B—the past – Journal of Antimicrobial Chemotherapy

Liposomal amphotericin B—the present – Journal of Antimicrobial Chemotherapy

Liposomal amphotericin B—the future – Journal of Antimicrobial Chemotherapy

 

RCT | Rezafungin vs. caspofungin for treatment of candidaemia and invasive candidiasis.

29 Nov, 2022 | 13:54h | UTC

Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Review | Infectious complications of abortion.

29 Nov, 2022 | 13:56h | UTC

Infectious Complications of Abortion – Open Forum Infectious Diseases

 

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.

27 Nov, 2022 | 22:30h | UTC

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet

News Release: One in eight deaths in 2019 linked to bacterial infections, the second leading cause of death globally – Institute for Health Metrics and Evaluation

Commentary: Report highlights the deadly impact of bacterial infections – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

RCT | Rectal culture-based vs. empirical antibiotic prophylaxis to prevent infections in men undergoing transrectal prostate biopsy.

27 Nov, 2022 | 22:28h | UTC

Rectal culture-based versus empirical antibiotic prophylaxis to prevent infectious complications in men undergoing transrectal prostate biopsy: a randomized, non-blinded multicenter trial – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Treatment of early Lyme Disease with doxycycline for 7 days is noninferior to treatment for 14 days.

23 Nov, 2022 | 14:06h | UTC

Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: Shorter Duration of Antibiotics Noninferior for Lyme Disease – JAMA (free for a limited period)

 

Commentary on Twitter

 

Epidemiology of ICU-onset bloodstream infection: prevalence, pathogens, and risk factors among 150,948 ICU patients.

21 Nov, 2022 | 14:14h | UTC

Epidemiology of ICU-Onset Bloodstream Infection: Prevalence, Pathogens, and Risk Factors Among 150,948 ICU Patients at 85 U.S. Hospitals* – Critical Care Medicine 

 

ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.

18 Nov, 2022 | 13:23h | UTC

ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment – Peritoneal Dialysis International

 

M-A | Efficacy and safety of treatments for different stages of syphilis.

18 Nov, 2022 | 13:20h | UTC

Efficacy and Safety of Treatments for Different Stages of Syphilis: a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials and Observational Studies – Microbiology Spectrum

 

M-A | A short course of antibiotics is noninferior to long-course therapy in children with nonsevere pneumonia.

16 Nov, 2022 | 13:43h | UTC

Short-Course vs Long-Course Antibiotic Therapy for Children With Nonsevere Community-Acquired Pneumonia: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Commentary: Review: Shorter antibiotic course sufficient for kids with pneumonia – CIDRAP

Related:

RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).

RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review – short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

 

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