Antibiotic Stewardship | Page 9 of 27 | Links Medicus Content Curation & Alerts in Medicine

Review | Early appropriate diagnostics and treatment of MDR Gram-negative infections.

7 Nov, 2022 | 12:19h | UTC

Early appropriate diagnostics and treatment of MDR Gram-negative infections – JAC-Antimicrobial Resistance

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

Commentary on Twitter

This is a ⚡fantastic article⚡
by super ?s Dr. Bassetti & @davidvanduin @jac_amr
We really need more adoption to RDTs coupled with stewardship programs
Early appropriate diagnostics and treatment of MDR Gram-negative infections #IDTwitter #MedEd https://t.co/h6eOvK2iH8 pic.twitter.com/WBjogJ6IYu

— Antibiotic Steward Bassam Ghanem?? (@ABsteward) September 14, 2022

Under a https://creativecommons.org/licenses/by/4.0/ license

Review | The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections.

7 Nov, 2022 | 12:17h | UTC

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

Early appropriate diagnostics and treatment of MDR Gram-negative infections – JAC-Antimicrobial Resistance

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

Review | How and when to manage respiratory infections out of hospital.

7 Nov, 2022 | 12:15h | UTC

How and when to manage respiratory infections out of hospital – European Respiratory Review

M-A | Prevalence, risk factors and treatments for post-COVID-19 breathlessness.

7 Nov, 2022 | 12:14h | UTC

Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis – European Respiratory Review

Review | Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD.

7 Nov, 2022 | 12:11h | UTC

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future – European Respiratory Review

Review | Non-Aspergillus mold lung infections.

7 Nov, 2022 | 11:51h | UTC

Non-Aspergillus mould lung infections – European Respiratory Review

Review | Respiratory viruses: their importance and lessons learned from COVID-19.

7 Nov, 2022 | 11:54h | UTC

Respiratory viruses: their importance and lessons learned from COVID-19 – European Respiratory Review

RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.

4 Nov, 2022 | 13:49h | UTC

Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial – The BMJ

RCT | Oral antimicrobial prophylaxis reduced surgical site infection after elective colorectal surgery.

4 Nov, 2022 | 13:48h | UTC

Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial – The BMJ

RCT | Povidone-iodine and chlorhexidine gluconate are similarly effective for preventing SSI in open fractures.

2 Nov, 2022 | 14:27h | UTC

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial – The Lancet (link to abstract – $ for full-text)

News Release: Study finds antisepsis agents interchangeable in reducing infection risk in open fracture surgeries – Louisiana State University

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Pragmatic randomized trial found similar rates of surgical site infectious with 2% alcoholic chlorhexidine skin preparation compared with povidone–iodine, or with triclosan-coated sutures compared with non-coated sutures.

RCT | Efficacy of RBX2660 for preventing recurrent Clostridioides difficile after antibiotic treatment.

1 Nov, 2022 | 12:07h | UTC

Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection – Drugs

Commentary: RBX2660 shows promise in breaking the cycle of recurrent C. difficile – MDedge

WHO Report | Fungal priority pathogens list to guide research, development and public health action.

28 Oct, 2022 | 13:31h | UTC

WHO fungal priority pathogens list to guide research, development and public health action – World Health Organization

News Release: WHO releases first-ever list of health-threatening fungi – World Health Organization

Commentary on Twitter (thread – click for more)

Fungal pathogens can cause illnesses and death.
They are becoming increasingly common and resistant to treatment.

Yet, too little is known about them.

The ? WHO fungal priority pathogens list is an important step to boost urgently needed research:
? https://t.co/cXgj2HPZIc pic.twitter.com/4LgdIqf4Lo

— World Health Organization (WHO) (@WHO) October 25, 2022

RCT | Selective decontamination of the GI tract did not significantly reduce mortality in ICU patients on mechanical ventilation.

27 Oct, 2022 | 12:40h | UTC

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

M-A | Selective decontamination of the GI tract may reduce in-hospital mortality in ICU patients receiving mechanical ventilation.

27 Oct, 2022 | 12:39h | UTC

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Post-trial follow-up | Microbiome therapeutic SER-109 through 24 weeks for recurrent Clostridioides difficile infection.

24 Oct, 2022 | 14:15h | UTC

Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial – JAMA (free for a limited period)

Original Study: RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).

Commentary on Twitter

SER-109, an investigational microbiome therapeutic comprised of purified Firmicutes spores, durably reduced recurrent Clostridioides difficile infection rates and was well-tolerated through 24 weeks in patients with prevalent comorbidities. https://t.co/abayN0iJ5z

— JAMA (@JAMA_current) October 19, 2022

Pneumonia update for emergency clinicians.

19 Oct, 2022 | 14:19h | UTC

Pneumonia Update for Emergency Clinicians – Current Emergency and Hospital Medicine Reports

Guideline | Diagnosis and management of febrile neutropenia in patients with cancer.

18 Oct, 2022 | 12:52h | UTC

The Dutch Working Party on Antibiotic Policy (SWAB) Recommendations for the Diagnosis and Management of Febrile Neutropenia in Patients with Cancer – Infectious Diseases and Therapy

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO) – Annals of Hematology

SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology

Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

Special Issue | Antibiotic resistance in the ICU.

17 Oct, 2022 | 12:28h | UTC

Homepage: Antibiotic Resistance

Editorial: Antibiotic Resistance

Antibiotic Stewardship in Critical and Emergency Care

Pharmacokinetic/Pharmacodynamic Principles to Combat Antimicrobial Resistance

Multidrug-Resistant Gram-Negative Bacteria in the ICU

Rapid Diagnostics and Antimicrobial Resistance in the ICU

Diagnostic Stewardship in Five Common Infectious Syndromes

Does Antimicrobial Resistance Affect Clinical Outcomes in the ICU?

Reducing Antibiotic Resistance in the ICU

Fungal infections | Pathogenesis, antifungals and alternate treatment approaches.

17 Oct, 2022 | 12:24h | UTC

Fungal infections: Pathogenesis, antifungals and alternate treatment approaches – Current Research in Microbial Sciences

Commentary on Twitter

Fungal infections:

Pathogenesis, antifungals and alternate treatment approacheshttps://t.co/JMcmzsL3GA #OpenAccess pic.twitter.com/5xAi5IGRGf

— MicrobesInfect (@MicrobesInfect) April 27, 2022

Under a Creative Commons license

M-A | Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections.

14 Oct, 2022 | 14:02h | UTC

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

Commentary on Twitter

To reduce risk of surgical site infections.
? chlorhexidine in alcohol better than iodine (esp non-clean surgery)
? but only at 2-2.5%. Higher concentration not better!
? olanexidine possible alternative but only 1x RCT@LancetMicrobe https://t.co/C8FHtEdYlf pic.twitter.com/FXwEOIg4Pf

— Gabriele Pollara (@gpollara) August 22, 2022

Illustrations under a Creative Commons Attribution (CC BY 4.0) license

Consensus Recommendations | Minimizing the risk of monkeypox virus transmission during fecal microbiota transplantation.

12 Oct, 2022 | 13:54h | UTC

Minimising the risk of monkeypox virus transmission during faecal microbiota transplantation: recommendations from a European expert panel – The Lancet Gastroenterology & Hepatology

Guideline Summary | Diagnostic stewardship for urinary tract infection.

11 Oct, 2022 | 13:37h | UTC

Diagnostic stewardship for urinary tract infection: A snapshot of the expert guidance – Cleveland Clinic Journal of Medicine

Original Guideline: Optimal Urine Culture Diagnostic Stewardship Practice—Results from an Expert Modified-Delphi Procedure – Clinical Infectious Diseases

RCT | Cefepime/Enmetazobactam vs. Piperacillin/Tazobactam in patients with complicated urinary tract infections.

6 Oct, 2022 | 13:49h | UTC

Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Cefepime/Enmetazobactam for Complicated Urinary Tract Infections – JAMA (free for a limited period)

Commentary on Twitter

In pts w complicated UTI or acute pyelonephritis caused by gram-negative pathogens, cefepime/enmetazobactam, vs piperacillin/tazobactam, met criteria for noninferiority & superiority w respect to primary outcome of clin cure & microbiological eradication https://t.co/Pn1sZH07QJ

— JAMA (@JAMA_current) October 4, 2022

Review | Antimicrobial stewardship programs focused on de-escalation.

6 Oct, 2022 | 13:36h | UTC

Antimicrobial stewardship programmes focused on de-escalation: a narrative review of efficacy and risks – Journal of Emergency and Critical Care Medicine

RCT | Topical antibiotics reduce the time to clinical cure in children with infective conjunctivitis.

5 Oct, 2022 | 13:55h | UTC

Effect of Topical Antibiotics on Duration of Acute Infective Conjunctivitis in Children: A Randomized Clinical Trial and a Systematic Review and Meta-analysis – JAMA Network Open

Commentaries:

Topical Antibiotics Linked With Reduced Duration of Acute Infective Conjunctivitis in Children – AJMC

Topical Antibiotics Shorten Duration of Conjunctival Symptoms – HealthDay

Commentary on Twitter

In this RCT and meta-analysis with 3 prior RCTs, children who received antibiotic eye drops had shorter duration of conjunctivitis vs. placebo. #OAResearch https://t.co/3mq5Fr8NDS

— JAMA Network Open (@JAMANetworkOpen) October 4, 2022

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