Open access
Open access
Powered by Google Translator Translator

Antibiotic Stewardship

M-A | Global status of azithromycin and erythromycin resistance rates in Neisseria gonorrhoeae

17 Feb, 2023 | 12:58h | UTC

Global status of Azithromycin and Erythromycin Resistance Rates in Neisseria gonorrhoeae: A Systematic Review and Meta-analysis – Yale Journal of Biology and Medicine

 

Case Reports | Seventeen cases of daptomycin-induced eosinophilic pneumonia in bone and joint infections

17 Feb, 2023 | 12:54h | UTC

Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm – Open Forum Infectious Diseases

 

M-A | Association between antimicrobial stewardship programs and antibiotic use globally

16 Feb, 2023 | 15:21h | UTC

Association Between Antimicrobial Stewardship Programs and Antibiotic Use Globally: A Systematic Review and Meta-Analysis – JAMA Network Open

Commentaries:

Antibiotic stewardship programs linked to reduced antibiotic prescribing, consumption worldwide – CIDRAP

Antimicrobial Stewardship Programs Beneficial for Cutting Antibiotic Use – HealthDay

 

M-A | Worldwide prevalence of antibiotic-associated Stevens-Johnson syndrome and toxic epidermal necrolysis

16 Feb, 2023 | 15:04h | UTC

Summary: The article examined the prevalence Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) associated with antibiotics worldwide. The analysis included 38 studies involving 2,917 patients, which showed that 28% of SJS/TEN cases were associated with antibiotics. Among antibiotic-associated SJS/TEN, the sulfonamide class was associated with 32% of cases, followed by penicillins, cephalosporins, fluoroquinolones, and macrolides.

Article: Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis – JAMA Dermatology (free for a limited period)

 

*Note: This summary was created through the collaboration of a medical editor and ChatGPT.

 

RCT | Antimicrobial therapy for 7 days is inferior to treatment for 14 days in men with febrile urinary tract infection

15 Feb, 2023 | 16:11h | UTC

Summary: This study aimed to compare the effectiveness of 7-day versus 14-day antibiotic treatment for febrile urinary tract infections in men. The multicenter randomized, double-blind, placebo-controlled non-inferiority trial enrolled 282 men from 27 centers in France. The primary endpoint was treatment success, defined as a negative urine culture, the absence of fever, and no subsequent antibiotic treatment between the end of treatment and 6 weeks after day 1. The results showed that the 14-day treatment was superior to the 7-day treatment, with a treatment success rate of 77.6% versus 55.7%, respectively. Adverse events were similar in both groups, and rectal carriage of resistant Enterobacterales did not differ. Therefore, the study concludes that treatment with ofloxacin for 7 days is inferior to 14 days for febrile UTI in men and should not be recommended.*

Article: Antimicrobial for 7 or 14 days for febrile urinary tract infection in men: a multicenter noninferiority double blind placebo-controlled, randomized clinical trial – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

*Note: This summary was created through the collaboration of a medical editor and ChatGPT.

 

Retrospective Study | Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome

15 Feb, 2023 | 15:40h | UTC

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome – Critical Care

 

Single-arm study | Effects of SER-109 as an investigational microbiome therapeutic in recurrent C. difficile infection

14 Feb, 2023 | 10:47h | UTC

Summary: This was a phase 3, open-label, single-arm trial of 263 adults with recurrent Clostridioides difficile Infection (CDI). The trial aimed to evaluate the safety and rate of CDI recurrence after administration of the investigational microbiome therapeutic SER-109. The trial found that SER-109 was well tolerated and the overall rate of recurrent CDI was low, regardless of the number of prior recurrences, demographics, or diagnostic approach.

(By ChatGPT, reviewed and edited)

 

Article: Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial – JAMA Network Open

Commentary: Phase 3 trial provides more positive data for recurrent C diff microbiome drug – CIDRAP

Related:

RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).

Post-trial follow-up | Microbiome therapeutic SER-109 through 24 weeks for recurrent Clostridioides difficile infection.

 

Cohort study | Epidemiology and outcomes of hospital-acquired bloodstream infections in ICU patients

14 Feb, 2023 | 10:44h | UTC

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Cohort Study | Global epidemiology of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases

14 Feb, 2023 | 10:43h | UTC

Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study – The Lancet Microbe

 

RCT | Azithromycin reduces the risk of maternal sepsis or death in women planning a vaginal birth

13 Feb, 2023 | 13:02h | UTC

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Single-dose antibiotic prevents maternal sepsis and death – NIH News

Commentaries:

In large study, a single antibiotic dose slashed rate of sepsis in childbirth – STAT

Dose of azithromycin found to cut risk of maternal death, sepsis in childbirth – CIDRAP

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth – News Medical/ University of Virginia Health System

 

Guideline for management of septic arthritis in native joints

10 Feb, 2023 | 14:00h | UTC

Guideline for management of septic arthritis in native joints (SANJO) – Journal of Bone and Joint Infection

 

SR | Mechanical plus oral antibiotic bowel preparation may prevent complications in elective colorectal surgery

10 Feb, 2023 | 13:53h | UTC

Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery – Cochrane Library

Summary: Can combined mechanical and oral antibiotic bowel preparation reduce the risk of complications after scheduled colon or rectal resections compared with purely mechanical, purely oral antibiotic or no bowel preparation? – Cochrane Library

Related:

M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.

Meta-Analysis: Effects of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery

 

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians

9 Feb, 2023 | 13:26h | UTC

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians – Intensive Care Medicine

 

Commentary on Twitter

 

An analysis of national action plans for antimicrobial resistance—gaps and opportunities in strategies optimizing antibiotic use

7 Feb, 2023 | 13:48h | UTC

An analysis of existing national action plans for antimicrobial resistance—gaps and opportunities in strategies optimising antibiotic use in human populations – The Lancet Global Health

 

Commentary on Twitter

 

Can the future of ID escape the inertial dogma of its past? The exemplars of shorter is better and oral is the new IV

7 Feb, 2023 | 13:34h | UTC

Can the Future of ID Escape the Inertial Dogma of Its Past? The Exemplars of Shorter Is Better and Oral Is the New IV – Open Forum Infectious Diseases

 

Guideline | Diagnosis and management of otitis media with effusion in children

6 Feb, 2023 | 13:23h | UTC

Clinical practice guidelines for the diagnosis and management of otitis media with effusion (OME) in children in Japan – 2022 update – Auris Nasus Larynx

 

Rates of antimicrobial resistance in Helicobacter pylori isolates across the US and Europe

6 Feb, 2023 | 13:12h | UTC

Rates of Antimicrobial Resistance in Helicobacter pylori Isolates From Clinical Trial Patients Across the US and Europe – The American Journal of Gastroenterology

Commentary: Time to ditch clarithromycin for H. pylori? – MDedge

 

Commentary on Twitter

 

Patients labeled as nonallergic after initial tests for penicillin allergy may develop resensitization afterwards

2 Feb, 2023 | 15:03h | UTC

Resensitization in suspected penicillin allergy – Allergy

Video summary: Resensitisation in suspected penicillin allergy

Commentary: Patients should be retested for penicillin resensitization before being deemed nonallergic – Healio (free registration required)

Related:

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs – JAC-Antimicrobial Resistance

Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC) – Journal of Investigational Allergology and Clinical Immunology (PDF)

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

Deconstructing the dogma: meta-analysis of adjunctive gentamicin and rifampin in staphylococcal prosthetic valve endocarditis

2 Feb, 2023 | 15:00h | UTC

Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Fungal Nomenclature: managing change is the name of the game

2 Feb, 2023 | 14:59h | UTC

Fungal Nomenclature: Managing Change is the Name of the Game – Open Forum Infectious Diseases

 

Commentary from the author on Twitter (thread – click for more)

 

A primer on home infusion administration methods

2 Feb, 2023 | 14:57h | UTC

A Primer on Home Infusion Administration Methods – Open Forum Infectious Diseases

 

M-A | Diagnostic value of bronchoalveolar lavage fluid galactomannan assay for invasive pulmonary aspergillosis

2 Feb, 2023 | 14:50h | UTC

Diagnostic value of bronchoalveolar lavage fluid galactomannan assay for invasive pulmonary aspergillosis in adults: A meta-analysis – Journal of Clinical Pharmacy and Therapeutics

 

RCT | Oral minocycline plus rifampicin vs. oral linezolid for complicated skin and skin structure infections caused by MRSA

2 Feb, 2023 | 14:33h | UTC

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial – eClinicalMedicine

 

Recommendations for non-HIV associated cryptococcal meningoencephalitis

1 Feb, 2023 | 13:20h | UTC

Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome – Frontiers in Neurology

 

Case Report | Novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium

1 Feb, 2023 | 13:13h | UTC

Novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium – Sexually Transmitted Infections

News Release: Common eye infection antibiotic may clear up treatment-resistant STI – BMJ Newsroom

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.