Antibiotic Stewardship
Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases
7 Mar, 2021 | 18:58h | UTC
Systematic Review: Different classes of antibiotics given to women routinely for preventing infection at cesarean section
5 Mar, 2021 | 08:27h | UTC
Respiratory microbiome in mechanically ventilated patients: a narrative review
5 Mar, 2021 | 08:14h | UTC
Commentary on Twitter
Respiratory microbiome on mechanical ventilation:
➡️definition
➡️state of the art: lung bacterial microbiota in #ICU, invasive mechanical ventilation, #ARDS, lung nosocomial infections & VAP, lung mycobiota, virome
➡️perspectives & clinical applicationshttps://t.co/fO7ggoJNUk pic.twitter.com/0W8hLNkuSO— Intens Care Med (@yourICM) February 9, 2021
WHO Action Framework: Leveraging vaccines to reduce antibiotic use and prevent antimicrobial resistance
5 Mar, 2021 | 08:08h | UTC
Addressing Antibiotic Overuse in the Outpatient Setting: Lessons From Behavioral Economics
4 Mar, 2021 | 08:27h | UTC
Chronic suppurative otitis media: Cochrane evidence on treatment options
3 Mar, 2021 | 08:26h | UTC
Studies: Secondary infections in patients with severe COVID-19
2 Mar, 2021 | 02:05h | UTCSecondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch
Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)
2 Mar, 2021 | 01:50h | UTC
Commentary on Twitter
We're delighted to publish the first update of UK #MRSA guidelines in more than a decade. Please share with your contacts & colleagues .
Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UKhttps://t.co/3o3OVIdLuB #JACAMRNews #IDtwitter pic.twitter.com/GGlv1C1T1g
— JAC-AMR (@jac_amr) February 4, 2021
Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge
2 Mar, 2021 | 01:46h | UTC
Commentary on Twitter
“Direct oral challenge safe & effective for de-labelling patients at low risk for true allergy. Important for optimizing patient care and tackling #AMR” https://t.co/S3VL8JXyFJ #JACAMRNews #AMR #AMS @SAPGAbx @lac_cooper @jenny_harbour @raseaton66 @jacquisneddons pic.twitter.com/SwE1yyVr8d
— JAC-AMR (@jac_amr) February 23, 2021
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
?NEW? PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone
24 Feb, 2021 | 02:25h | UTCEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)
Commentary on Twitter
VICTAS trial now in @JAMA_current. Is this the final nail in the coffin for HAT in sepsis? https://t.co/kDdmnIdC6s
— UGAC3 (@ugac3) February 23, 2021
Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone
24 Feb, 2021 | 02:16h | UTCCommentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP
Global guideline for the diagnosis and management of rare mold infections
19 Feb, 2021 | 02:18h | UTC
Commentary on Twitter
??? Global Guideline for Rare Moulds. Endorsed by 55 scientific societies in the field.
All you need to know about Diagnosis and Treatment of Rare Mould infections: from Fusarium to Purpureocillium. @eurconfmedmycol @ISHAM_Mycology @ASMicrobiology
https://t.co/YJ3BX58osW pic.twitter.com/nrAGZl5ox4— Martin Hoenigl (@martinhoenigl) February 16, 2021
Serology anno 2021 – fungal infections: from invasive to chronic
17 Feb, 2021 | 01:19h | UTC
Commentary on Twitter
?A masterpiece Review Article? @CMIJournal
An updated 2021 inventory of fungal antigen and serology tests for diagnosing invasive and chronic fungal infections, focus was set on Aspergillus,Candida &
Cryptococcus species #IDTwitter #Fungtwitter https://t.co/vG27LagCw7 pic.twitter.com/66la84ixXN— Antibiotic Steward? Bassam Ghanem (@ABsteward) February 16, 2021
Study: Obesity and risk of catheter-related infections in the ICU
16 Feb, 2021 | 01:46h | UTC
Commentary on Twitter
Obesity & intravascular catheter‑related infections in #ICU, post hoc analysis of 4 multicentric RCTs, largest dataset ever collected:
BMI ≥ 40? ⬆️risk!!
Preventive strategies, notably catheter care/dressing disruption, should focus on this pt population.https://t.co/ZxBFAxz2Je pic.twitter.com/7GHov7ewkr— Intens Care Med (@yourICM) February 1, 2021
Corticosteroids for community acquired pneumonia, influenza and COVID-19: when, how and benefits or harm?
15 Feb, 2021 | 00:47h | UTC
Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis
15 Feb, 2021 | 00:43h | UTC
RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections
12 Feb, 2021 | 02:02h | UTCDelayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)
Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP
Cohort study: The use of macrolide antibiotics in pregnancy is not associated with an increased risk of major congenital malformations
12 Feb, 2021 | 02:04h | UTC
Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis
11 Feb, 2021 | 01:50h | UTCRelated: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care
Commentary on Twitter
? New paper from our team @HopitalCochin ⤵️
New data supporting a drug-drug interaction between vancomycin and piperacillin ⚠️ increased risk of acute kidney injury | Great collab with @AdrienContejean@KerneisSolen
Read more in @BSACandJAC ⤵️https://t.co/eQW5s52fOY@ABsteward— Laurent Chouchana (@LChouchana) February 1, 2021
RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter
11 Feb, 2021 | 01:52h | UTC
CDC study on practical ways for maximizing fit for masks to reduce SARS-CoV-2 transmission and exposure
11 Feb, 2021 | 02:25h | UTCCommentaries: CDC Says Double-Masking Offers More Protection Against The Coronavirus – NPR AND CDC report: Double-masking can block more than 90 percent of viral particles – NBC News
Cohort study: Adjunctive clindamycin may benefit beta-lactam antibiotic-treated patients with invasive beta-hemolytic streptococcal infections
10 Feb, 2021 | 01:13h | UTCEffectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary on Twitter
Our new study in Lancet ID ?? showing a potential role for wider adjunctive use of clindamycin for iGAS even without next fasc or toxic shock. Utility in non-A,non-B strep questionable. Congratulations to stellar first author @Ahmed_HBabiker https://t.co/3t4FsmClWa
— Sameer Kadri (@SameerKadri12) December 15, 2020
Review: Nosocomial infection in the ICU setting
9 Feb, 2021 | 01:05h | UTCNosocomial Infection – Critical Care Medicine
RCT: Posaconazole noninferior to voriconazole for primary treatment of invasive aspergillosis
7 Feb, 2021 | 21:00h | UTCPosaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)