General Hematology
Review: Histiocytic disorders.
24 Jan, 2022 | 08:02h | UTCHistiocytic disorders – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Histiocytic disorders (if the link is paywalled, try this one)
Commentary on Twitter
Haemophagocytic lympho #histiocytosis is a syndrome of extreme #immune activation; common manifestations include involvement of the central nervous system, hepatitis or acute liver failure.https://t.co/heXWqru8wW pic.twitter.com/1A0SFIhkwR
— Nature Reviews Disease Primers (@DiseasePrimers) January 21, 2022
Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 Update.
21 Jan, 2022 | 09:53h | UTC
Expert consensus for plasma and platelet transfusion practice in critically ill children.
20 Jan, 2022 | 08:44h | UTC
RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.
19 Jan, 2022 | 08:56h | UTCEditorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA
Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay
Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.
18 Jan, 2022 | 09:41h | UTC
Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.
14 Jan, 2022 | 08:18h | UTCTransfusion thresholds for guiding red blood cell transfusion – Cochrane Library
Related:
Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA
Commentary on Twitter
Less can be more: updated Cochrane review strengthens conclusions on safety of restrictive transfusion thresholds https://t.co/uKkvX5UJrS @EUBloodAlliance @WHO @AABB @NIHRresearch @CochraneLibrary @NICEComms @NHSBT @RutgersU @LSHTM @RDMOxford #transfusionmedicine pic.twitter.com/2QXQNqzvPK
— Cochrane Injuries (@cochraneINJ) December 22, 2021
The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.
12 Jan, 2022 | 09:11h | UTC
RCT: Among patients younger than 21 years of age with provoked thromboembolism, anticoagulation for 6 weeks was non-inferior vs. 12 weeks on the risk of recurrence and bleeding events.
12 Jan, 2022 | 08:53h | UTCEffect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Duration of Anticoagulant Treatment for Acute Provoked Venous Thromboembolism in Pediatric Patients – JAMA (free for a limited period)
RCT: Eltrombopag added to immunosuppression is associated with improved hematologic response vs. immunosuppression alone in previously untreated patients with severe aplastic anemia.
12 Jan, 2022 | 08:46h | UTCEltrombopag Added to Immunosuppression in Severe Aplastic Anemia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A randomized trial comparing immunosuppression (horse ATG and cyclosporine) with the same therapy plus eltrombopag showed more rapid and complete responses with the addition of eltrombopag. https://t.co/nH7rkeCMAS pic.twitter.com/i8iTIq8FSG
— NEJM (@NEJM) January 5, 2022
RCT: Interferon-alpha vs. Hydroxyurea in Polycythemia Vera and Essential Thrombocythemia.
12 Jan, 2022 | 08:35h | UTC
Review: Management of coagulopathy in bleeding patients.
12 Jan, 2022 | 08:34h | UTCManagement of Coagulopathy in Bleeding Patients – Journal of Clinical Medicine
RCT: In children with sickle cell anemia, hydroxyurea in moderate doses (20 mg/kg per day) is not better than low doses (10 mg/kg per day) for primary stroke prevention.
11 Jan, 2022 | 02:10h | UTCHydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)
[Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.
8 Jan, 2022 | 23:28h | UTCNews release: Early Use of Convalescent Plasma May Help Outpatients with COVID-19 Avoid Hospitalization – Johns Hopkins Medicine
Commentary: Convalescent plasma shows renewed promise for COVID-19 in outpatient trial – Science
In a large retrospective cohort study of patients with atrial fibrillation 65 years or older, treatment with rivaroxaban compared with apixaban was associated with increased risk of major ischemic or hemorrhagic events.
8 Jan, 2022 | 22:37h | UTCCommentary: Apixaban Appears Safer, More Effective Than Rivaroxaban in Medicare Study – TCTMD
Related:
Retrospective cohort study: In patients with venous thromboembolism (VTE), treatment with apixaban was associated with lower rates for recurrent VTE and bleeding compared to rivaroxaban.
8 Jan, 2022 | 22:36h | UTCCommentaries:
Apixaban shows superior effectiveness, safety compared to rivaroxaban – ACP Internist
Recurrent VTE and Bleeding With Apixaban vs. Rivaroxaban – American College of Cardiology
RCT: Among patients hospitalized with COVID-19 at increased risk for venous thromboembolism, post-discharge thromboprophylaxis with Rivaroxaban for 35 days may improve outcomes.
17 Dec, 2021 | 09:50h | UTCInvited commentary: Anticoagulation in COVID-19 – The Lancet
Commentary on Twitter
NEW: The role of extended thromboprophylaxis in patients hospitalised with COVID-19 at risk for thrombotic events after discharge – findings from MICHELLE trial https://t.co/OWcmjCLBTw pic.twitter.com/3Bl4lV16Va
— The Lancet (@TheLancet) December 16, 2021
How to recognize and manage COVID-19-associated coagulopathy.
13 Dec, 2021 | 09:45h | UTCHow to recognize and manage COVID-19-associated coagulopathy – Hematology, ASH Education Program
COVID-19 and thrombosis: searching for evidence.
13 Dec, 2021 | 09:47h | UTCCOVID-19 and thrombosis: searching for evidence – Hematology, ASH Education Program
Hematology, the ASH Education Program – series of review articles with clinical cases published annually by the American Society of Hematology.
13 Dec, 2021 | 08:45h | UTCHomepage: Hematology, the ASH Education Program
Update in the diagnosis and management of acute pulmonary embolism for the non-respiratory physician.
9 Dec, 2021 | 10:00h | UTC
WHO recommends against the use of convalescent plasma to treat COVID-19.
8 Dec, 2021 | 10:24h | UTCNews Release: WHO recommends against the use of convalescent plasma to treat COVID-19 – World Health Organization
See Guidance: WHO’s living guidelines on COVID-19 therapeutics
Infographic: A living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter (thread – click for more)
Convalescent plasma is a transfusion of blood plasma from someone who has recovered from #COVID19, and is used as a treatment for COVID19 https://t.co/Bobq7OTDGq pic.twitter.com/pfO1sFvUpJ
— World Health Organization (WHO) (@WHO) December 7, 2021
ESC Position Paper: Optimal follow-up after acute pulmonary embolism.
8 Dec, 2021 | 10:02h | UTC
Commentary on Twitter
Do you routinely discuss how/when to resume sporting activities and traveling with your PE patients? Or future cardiovascular risk? Check this recent ESC/ERS position paper on optimal follow-up of acute PE for these and other key aspects of counselling: https://t.co/KEQ7FnFwXX
— Erik Klok (@Erik_Klok_MD) December 7, 2021
Another randomized trial showed convalescent plasma does not benefit patients hospitalized with Covid-19.
1 Dec, 2021 | 09:49h | UTCRelated:
M-A: Convalescent plasma does not reduce mortality in COVID-19.
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Commentary on Twitter
The TSUNAMI RCT showed that high-titer convalescent plasma (CP) did not reduce the risk of severe respiratory failure or death in hospitalized patients with #COVID19 pneumonia. https://t.co/4q0S2AtfMj
— JAMA Network Open (@JAMANetworkOpen) November 29, 2021
Review: Castleman disease.
26 Nov, 2021 | 09:49h | UTCCastleman disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Castleman Disease (if the link is paywalled, try this one)
Review: Prevention and management of thrombosis in hospitalized patients with COVID-19 pneumonia.
26 Nov, 2021 | 08:44h | UTC