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General Hematology

Valoctocogene Roxaparvovec gene therapy for Hemophilia A.

21 Mar, 2022 | 08:27h | UTC

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Valoctocogene Roxaparvovec Evaluated in Severe Hemophilia A – HealthDay

Hemophilia A Gene Therapy Reduced Bleeding Events, Need for Clotting Factors – AJMC

 

Guideline: Management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period.

18 Mar, 2022 | 09:39h | UTC

American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period – Journal of the Canadian Association of Gastroenterology

 

Commentary on Twitter

 

Happy TRALIdays: An overview of trauma resuscitation and transfusion complications.

17 Mar, 2022 | 08:08h | UTC

Happy TRALIdays: An Overview of Trauma Resuscitation and Transfusion Complications – emDocs

 

Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.

14 Mar, 2022 | 01:47h | UTC

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Related:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

 

Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.

10 Mar, 2022 | 10:48h | UTC

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

Commentary on Twitter

 

Perspective: Once viewed as a promising COVID-19 treatment, convalescent plasma falls out of favor.

10 Mar, 2022 | 10:47h | UTC

Once Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA

 

RCT: In patients with trauma-related hemorrhagic shock receiving prehospital care, there was no benefit from resuscitation with blood products compared to 0.9% sodium chloride.

9 Mar, 2022 | 09:55h | UTC

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet Haematology

Invited commentary: Prehospital blood transfusion: who benefits? – The Lancet Haematology

 

Commentary on Twitter

 

Systematic Review: Anticoagulants for people hospitalized with COVID‐19.

7 Mar, 2022 | 00:48h | UTC

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Summary: Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots? – Cochrane Library

Related: Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

 

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

2 Mar, 2022 | 09:03h | UTC

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Commentary: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology

 

Two large populational-based studies find a slightly increased risk of thrombotic events following AstraZeneca COVID-19 vaccination.

24 Feb, 2022 | 10:23h | UTC

Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England – PLOS Medicine

See also: First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales – PLOS Medicine

Commentaries:

Two studies find only small elevated risk of blood clots following AstraZeneca COVID-19 vaccination – PLOS

Two Large Studies Affirm Rare Thrombosis Risk With ChAdOx1 COVID-19 Vax – TCTMD

 

Review: Cancer-associated venous thromboembolism.

21 Feb, 2022 | 08:42h | UTC

Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Related:

NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.

ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer

Review: venous and arterial thromboembolism in patients with cancer.

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage

Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

 

Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study.

16 Feb, 2022 | 08:39h | UTC

Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study – The BMJ

 

A large cohort of patients with nephrotic syndrome showed the risk of arterial thromboembolism (HR = 3.11), venous thromboembolism (HR = 7.11), and bleeding (HR = 4.02) was greatly increased after adjusting for confounders.

15 Feb, 2022 | 08:47h | UTC

Risk of arterial thromboembolism, venous thromboembolism, and bleeding in patients with nephrotic syndrome: A population-based cohort study – American Journal of Medicine (link to abstract – $ for full-text)

 

Review: Management of venous thromboembolism in pregnancy.

13 Feb, 2022 | 21:57h | UTC

Management of venous thromboembolism in pregnancy – Thrombosis Research

Related:

Management of high-risk pulmonary embolism in pregnancy.

Study: Diagnosis of Pulmonary Embolism During Pregnancy

Imaging is the only way to diagnose blood clots in pregnancy

Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines

 

Betibeglogene Autotemcel gene therapy for Non–beta0/beta0 Genotype beta-thalassemia.

13 Feb, 2022 | 21:46h | UTC

Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

IDSA Updated Covid-19 Guideline now supports the use of convalescent plasma in ambulatory patients with mild to moderate COVID-19 at high risk for progression to severe disease.

9 Feb, 2022 | 10:15h | UTC

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

Related: [Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.

 

Commentary on Twitter

 

Expert Consensus: Treatment algorithm in cancer-associated thrombosis.

9 Feb, 2022 | 08:42h | UTC

Treatment Algorithm in Cancer-Associated Thrombosis: Updated Canadian Expert Consensus – Current Oncology

 

Review | Prehospital plasma transfusion: what does the literature show?

9 Feb, 2022 | 08:22h | UTC

Prehospital Plasma Transfusion: What Does the Literature Show? – Transfusion Medicine and Hemotherapy

 

Review | Emergency blood transfusion for trauma and perioperative resuscitation.

9 Feb, 2022 | 08:22h | UTC

Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care – Transfusion Medicine and Hemotherapy

 

In patients taking anticoagulants (DOAC or Warfarin), a respiratory tract infection not treated with antibiotics is associated with a greater than twofold increase in the risk of bleeding during the next 0-14 days.

8 Feb, 2022 | 08:46h | UTC

Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series – The BMJ

 

Commentary on Twitter

 

DIC in Pregnancy: Pathophysiology, clinical characteristics, diagnostic scores, and treatments.

2 Feb, 2022 | 08:27h | UTC

DIC in Pregnancy – Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments – Journal of Blood Medicine

 

Registry study in Denmark found an increased bleeding risk with the association of systemic Fluconazole and Apixaban (OR 3.5; 95% CI, 1.4-10.6).

1 Feb, 2022 | 08:13h | UTC

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

 

Guideline Summary: Management of the top 10 most common immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

30 Jan, 2022 | 14:11h | UTC

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Original Article: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Related:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (several resources on the subject)

 

Systematic Review: Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism.

30 Jan, 2022 | 14:04h | UTC

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism – Cochrane Library

 

ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

28 Jan, 2022 | 08:26h | UTC

2021 ELSO Adult and Pediatric Anticoagulation Guidelines – ASAIO Journal

 

Commentary on Twitter

 

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