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Family Medicine

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.

1 Apr, 2022 | 08:44h | UTC

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive – The Conversation

Related:

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies

Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization

Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women

Randomized trial: Freeze-all vs. fresh blastocyst transfer strategy during in vitro fertilization in women with regular menstrual cycles

 


Practice review: Evidence-based and effective management of anemia in palliative care patients.

1 Apr, 2022 | 08:21h | UTC

Practice review: Evidence-based and effective management of anaemia in palliative care patients – Palliative Medicine

 


Practice review: Evidence-based management approaches for patients with severe chronic obstructive pulmonary disease (COPD).

1 Apr, 2022 | 08:29h | UTC

Evidence-based management approaches for patients with severe chronic obstructive pulmonary disease (COPD): A practice review – Palliative Medicine

 


Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer.

1 Apr, 2022 | 08:26h | UTC

Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer – Palliative Medicine

 


WHO recommendations on maternal and newborn care for a positive postnatal experience.

31 Mar, 2022 | 08:47h | UTC

WHO recommendations on maternal and newborn care for a positive postnatal experience – World Health Organization

News Release: WHO urges quality care for women and newborns in critical first weeks after childbirth – World Health Organization

Commentary: Postnatal care: WHO highlights urgency of physical and mental support – The BMJ

 


RCT: Early treatment with ivermectin does not improve outcomes in patients with Covid-19.

31 Mar, 2022 | 08:41h | UTC

Effect of Early Treatment with Ivermectin among Patients with Covid-19- New England Journal of Medicine

Commentary: Ivermectin does not prevent COVID-19 hospitalization, a new study says – NPR

 

Commentary on Twitter

 


USPSTF Draft Recommendation Statement: the current evidence is insufficient to recommend screening for obstructive sleep apnea in asymptomatic individuals.

31 Mar, 2022 | 08:42h | UTC

Draft Recommendation Statement: Obstructive Sleep Apnea in Adults: Screening – US Preventive Services Task Force

Commentary: USPSTF: Evidence Lacking for OSA Screening in Asymptomatic Adults – HealthDay

 


Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study in England.

31 Mar, 2022 | 08:29h | UTC

Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study between January, 2020, and July, 2021, in England – The Lancet Child & Adolescent Health

Invited Commentary: Importance of understanding the reinfection risk of COVID-19 in children – The Lancet Child & Adolescent Health

 

Commentary on Twitter

 


Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

31 Mar, 2022 | 08:31h | UTC

P2Y12 Inhibitor versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Trials – European Heart Journal Open

Commentary: Clopidogrel Superior to ‘Divine’ Aspirin Monotherapy in Secondary Prevention – TCTMD

 

Commentary on Twitter

 


Case-control study: In children 5 to 11 years of age, the Pfizer vaccine showed an effectiveness of 68% against hospitalization caused by the Omicron variant.

31 Mar, 2022 | 08:37h | UTC

BNT162b2 Protection against the Omicron Variant in Children and Adolescents – New England Journal of Medicine

Commentary: COVID vaccination of children age 5-11 cut omicron hospitalizations by 68% – Children’s Hospital Boston

Related: [Preprint] Study shows significantly reduced effectiveness of the Pfizer vaccine in children 5 to 11 after the emergency of the Omicron variant.

 

Commentary on Twitter

 


M-A: Psychological interventions for chronic, non-specific low back pain.

31 Mar, 2022 | 08:20h | UTC

Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis – The BMJ

News Release: Study sheds light on psychological therapies for chronic low back pain – British Medical Journal

 


Cohort Study: Mortality associated with mental disorders and comorbid general medical conditions.

31 Mar, 2022 | 08:15h | UTC

Mortality Associated With Mental Disorders and Comorbid General Medical Conditions – JAMA Psychiatry

Commentary: People with Mental Disorders, General Comorbid Conditions Have 11-Year Reduced Life Expectancy – HCP Live

 


Rickets guidance: part II—management.

31 Mar, 2022 | 08:08h | UTC

Rickets guidance: part II—management – Pediatric Nephrology

Related: Rickets guidance: part I—diagnostic workup.

 


The incidence of adult-onset Type 1 Diabetes: a systematic review from 32 countries and regions.

31 Mar, 2022 | 07:52h | UTC

The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions – Diabetes Care

 


[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

30 Mar, 2022 | 10:44h | UTC

Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old – Research Square

Commentaries:

Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s – Health Policy Watch

Fourth COVID-19 vaccine dose substantially reduces mortality in the elderly – News Medical

 


U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

30 Mar, 2022 | 10:42h | UTC

U.S. approves second Covid-19 booster for people 50 and older – STAT

FDA OKs second COVID booster shot for older Americans – CIDRAP

See Guidance: Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

 


Study shows overtreatment of diabetes common in nursing home residents with type 2 diabetes.

30 Mar, 2022 | 10:27h | UTC

Glycemic treatment deintensification practices in nursing home residents with type 2 diabetes – Journal of the American Geriatrics Society

Commentaries:

Overtreatment of T2DM Common Among VA Nursing Home Residents – HealthDay

Diabetes treatment deintensification uncommon in nursing home residents – medwire News

 


Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study.

30 Mar, 2022 | 10:24h | UTC

Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study – The BMJ

 

Commentary on Twitter

 


Retrospective Cohort Study: Risks for anaphylaxis with intravenous iron formulations.

30 Mar, 2022 | 10:16h | UTC

Risks for Anaphylaxis With Intravenous Iron Formulations: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Risk of Severe Allergic Reaction Higher with Two Intravenous Iron-Boosting Products – Rutgers University

Commentary: Risks for Anaphylaxis Compared Among IV Iron Products – HealthDay

 


Systematic Review: Probiotics for treatment of chronic constipation in children.

30 Mar, 2022 | 10:12h | UTC

Probiotics for treatment of chronic constipation in children – Cochrane Library

Summary: Probiotics for treatment of chronic constipation in children – Cochrane Library

 


Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019.

30 Mar, 2022 | 09:55h | UTC

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019 – The Lancet Child & Adolescent Health

Invited Commentary: 30-year NCD burden data for EU adolescents merit close attention – The Lancet Child & Adolescent Health (free registration required)

 

Commentary on Twitter (thread – click for more)

 


Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

 

Commentary on Twitter

 


Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

29 Mar, 2022 | 10:16h | UTC

Cost-effectiveness of a Household Salt Substitution Intervention: Findings From 20,995 Participants of the Salt Substitute and Stroke Study (SSaSS) – Circulation

Commentary: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay

Original Study: #ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Related:

Former CDC director: Low sodium salt could save millions of lives – CNN

Is salt good for you after all? The evidence says no.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 


Meta-analysis of randomized trials: GLP1 receptor agonists increase the risk of gallbladder and biliary diseases (RR, 1.37; 95% CI, 1.23-1.52).

29 Mar, 2022 | 10:02h | UTC

Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)

Commentary: GLP-1 Receptor Agonists: How Safe Are They for the Gallbladder?— Link with gallbladder, biliary diseases could be due to weight loss associated with class of drug – MedPage Today (free registration required)

 


Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

 


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