Family Medicine
RCT: Effect of intramuscular vs. intra-articular glucocorticoid injection on pain among adults with knee osteoarthritis.
7 Apr, 2022 | 08:35h | UTC
Commentary on Twitter
This RCT found IM steroid injections were inferior to intrarticular injections for reducing pain in patients with knee osteoarthritis at 4 weeks but were noninferior at 8 and 24 weeks after injection. https://t.co/opq1C2BP8c pic.twitter.com/ucx4lvRDJQ
— JAMA Network Open (@JAMANetworkOpen) April 5, 2022
Cohort Study: Comparison of rates of Type 2 Diabetes in adults and children treated with anticonvulsant mood stabilizers.
7 Apr, 2022 | 08:32h | UTC
Commentary on Twitter
This cohort study found that the choice of which anticonvulsant mood stabilizer to initiate may have meaningful reductions in type 2 diabetes incidence; valproate was associated with the highest risk and lamotrigine the lowest. https://t.co/pyME0G25wt
— JAMA Network Open (@JAMANetworkOpen) April 6, 2022
Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.
6 Apr, 2022 | 10:59h | UTCProtection by a Fourth Dose of BNT162b2 against Omicron in Israel – New England Journal of Medicine
Commentary: Mixed Bag for Fourth Dose of Pfizer Vaccine vs Omicron— Real-world data show less infection and severity, but long-term benefit less clear – MedPage Today (free registration required)
Related:
Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Covid-19: Fourth vaccine doses—who needs them and why?
[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.
Commentary on Twitter
Just published @NEJM
4th dose vaccine protection in >620,000 people vs 3-doses in >620,000, all age 60+, Omicron wave, Israel
—4-fold lower rate of severe disease, no waning at 6 weeks
—2-fold lower rate of infection, rapidly wanedhttps://t.co/g8uGMXGHD6 pic.twitter.com/D7WHywTI1j— Eric Topol (@EricTopol) April 5, 2022
Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.
6 Apr, 2022 | 10:52h | UTC
Commentary on Twitter
In this cohort study, the incidence rate of #SARSCoV2 infection with Omicron variant was 6 to 8 times that of Delta variant in children younger than 5 years, but severe clinical outcomes were less frequent than with Delta variant. https://t.co/UKiMEznXtX
— JAMA Pediatrics (@JAMAPediatrics) April 1, 2022
M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.
6 Apr, 2022 | 10:55h | UTC
Review and M-A: pulmonary rehabilitation for Post-Covid.
6 Apr, 2022 | 10:42h | UTC
Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019.
6 Apr, 2022 | 10:49h | UTCNews Release: Global disparities persist in opioid painkiller access – University College London
Invited Commentary: Closing the global pain divide: balancing access and excess – The Lancet Public Health
Commentary on Twitter (article and images under a Creative Commons Attribution (CC BY 4.0 license)
Just Out @TheLancetPH 🚨
Global #opioids consumption increased from 2015 to 2019‼️#Disparities in opioid💊consumption remained, indicating potential inadequate access to essential pain relief in countries with low consumption🌐https://t.co/bkcdgLy3ZP pic.twitter.com/RUGl1gbiTw— Gil Morgan, MD (@weoncologists) April 1, 2022
Cohort study and updated meta-analysis: greater dietary cholesterol and egg consumption linked to increased risk of overall and CVD mortality.
6 Apr, 2022 | 10:41h | UTC
Canadian recommendations on prostate cancer screening and early diagnosis.
6 Apr, 2022 | 09:47h | UTCSee also: Summary of changes
Opinion | Medicinal cannabis for chronic pain: the Bermuda triangle of low-quality studies, countless meta-analyses and conflicting recommendations.
5 Apr, 2022 | 08:52h | UTCRelated:
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know
Cohort study: Increased middle age serum sodium levels (may correlate with low water ingestion) are linked to increased risk of left ventricular hypertrophy and heart failure after 25 years of follow up.
5 Apr, 2022 | 09:44h | UTCMiddle age serum sodium levels in the upper part of normal range and risk of heart failure – European Heart journal (link to abstract – $ for full-text)
M-A: Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain.
5 Apr, 2022 | 08:29h | UTC
Cohort Study: Childhood cardiovascular risk factors and adult cardiovascular events.
5 Apr, 2022 | 08:23h | UTCChildhood Cardiovascular Risk Factors and Adult Cardiovascular Events – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Childhood cardiovascular risk factors including BMI, systolic blood pressure, lipid levels, and smoking were correlated with cardiovascular events in adulthood after a mean follow-up of 35 years. #ACC22 https://t.co/fh2SoQ09Qq pic.twitter.com/cZiYYGEubF
— NEJM (@NEJM) April 4, 2022
Review: Patient-centered approaches for the management of unpleasant symptoms in kidney disease.
5 Apr, 2022 | 08:16h | UTC
Commentary on Twitter
In this Perspectives article, @kamkalantar and colleagues examine the concept & scope of symptom burden in #CKD, & discuss patient-centered approaches for the management of unpleasant symptoms in kidney disease https://t.co/ILBtWA3LTc pic.twitter.com/BYsoam1HeX
— Nature Reviews Nephrology (@NatRevNeph) January 25, 2022
Systematic Review: Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.
5 Apr, 2022 | 08:10h | UTC
Review: Treatment strategies to improve outcomes in patients with chronic idiopathic constipation and irritable bowel syndrome with constipation.
5 Apr, 2022 | 08:00h | UTC
#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.
4 Apr, 2022 | 01:42h | UTCACC Guideline Hub: Heart Failure
Executive Summary: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
News Release: ACC, AHA, HFSA Issue Heart Failure Guideline – American Heart Association
Key Perspectives: 2022 AHA/ACC/HFSA Heart Failure Guideline
Slide Set Download: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Commentary on Twitter
New ACC/AHA/HFSA clinical guideline provides patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with #HeartFailure.
Get the details in #JACC: https://t.co/zfbKMXxDNf#ClinicalGuidelines #HFrEF #CardioTwitter pic.twitter.com/hrvTj4TQUm
— JACC Journals (@JACCJournals) April 1, 2022
#ACC22 – RCT: Treatment for mild chronic hypertension during pregnancy is associated with better pregnancy outcomes than a strategy of reserving treatment only for severe hypertension.
4 Apr, 2022 | 01:34h | UTCTreatment for Mild Chronic Hypertension during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Treating chronic hypertension in early pregnancy benefits parents, babies – NIH News Releases
CHAP: Better Blood Pressure Control, Better Pregnancy Outcomes – TCTMD
Commentary on Twitter
In pregnant women with mild chronic hypertension, targeting a blood pressure of < 140/90 mm Hg was associated with better pregnancy outcomes than a strategy of reserving treatment only for severe hypertension. #ACC22 https://t.co/fDrqa8uQiO pic.twitter.com/9KvogjnKcc
— NEJM (@NEJM) April 2, 2022
#ACC22 – RCT: Among ambulatory patients with heart failure, a dietary intervention to reduce sodium intake did not reduce clinical events.
4 Apr, 2022 | 01:32h | UTCReduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial – The Lancet (free registration required)
Commentaries:
SODIUM-HF: No Impact of Dietary Salt Restriction on Death or Hospitalization – TCTMD
Commentary on Twitter
Nutritional counseling/strictly limiting sodium intake didn’t significantly reduce MACE in #HeartFailure patients in 6️⃣ countries, but did modestly improve QOL according to results of SODIUM-HF trial presented at #ACC22. https://t.co/ESjiy6g8a7 #ACCIntl #cvPrev #CardioNutrition pic.twitter.com/CjK6CfWNXg
— American College of Cardiology (@ACCinTouch) April 2, 2022
Two new studies show vaccination provides additional protection after Covid-19 infection.
4 Apr, 2022 | 01:16h | UTCCommentaries:
Vaccines offer substantial extra protection after COVID-19 infection – CIDRAP
Had COVID? Getting Vaccine Boosts Resilience Even More, Studies Show – HealthDay
Related:
Commentary on Twitter (thread – click for more)
THREAD | New studies in @TheLancetInfDis confirm #COVID19 vaccines provide extra protection for those with immunity from previous infection, especially against severe disease ⤵️
(Cases of reinfection from omicron variants not included)
— The Lancet (@TheLancet) April 1, 2022
RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.
1 Apr, 2022 | 10:07h | UTCCommentaries:
Study raises questions about risks of using medical marijuana for mood and anxiety disorders – CNN
Medical Marijuana Rx Ups Odds for Overuse, With No Benefit to Health: Study – HealthDay
Commentary on Twitter
RCT finds medical marijuana cards (MMC) are linked to an increase in cannabis use disorder, with no improvements in pain, depression, and anxiety for adults using medical marijuana but improvements in sleep. https://t.co/0gtGFi1RQ9
— JAMA Network Open (@JAMANetworkOpen) March 18, 2022
Still coughing after COVID? Here’s why it happens and what to do about it.
1 Apr, 2022 | 09:50h | UTCStill coughing after COVID? Here’s why it happens and what to do about it – The Conversation
Study finds mother-to-child transmission of COVID-19 infection is possible but rare.
1 Apr, 2022 | 09:52h | UTCNews Release: Mother to child transmission of COVID-19 infection, possible but rare, study finds – University of Birmingham
Original Study: SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis – The BMJ
Editorial: Transmission of SARS-CoV-2 from mother to baby is rare
Commentary on Twitter
Mother-to-child transmission of SARS-CoV-2 has been controversial. Our living systematic review & meta-analysis has just been published in BMJ. Transmission has been confirmed, although it is rare, & is more likely when the maternal COVID-19 is severe.https://t.co/Z15kFIk6Zp
— Asma Khalil (@ProfAsmaKhalil) March 19, 2022
Viewpoint: Evaluating the effectiveness of diagnostic tests.
1 Apr, 2022 | 09:47h | UTCEvaluating the Effectiveness of Diagnostic Tests – JAMA (free for a limited period)
Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study.
1 Apr, 2022 | 08:49h | UTCInvited Commentary: The actual burden of obesity—accounting for multimorbidity – The Lancet Diabetes & Endocrinology (free registration required)
Commentary on Twitter
In the April Issue:
Body-mass index and risk of #obesity-related complex #multimorbidity: an observational multicohort study https://t.co/I2AqM9FmKd #BMI #OpenAccess pic.twitter.com/36f7J5VDZU— The Lancet Diabetes & Endocrinology (@TheLancetEndo) March 30, 2022