Open access
Open access
Powered by Google Translator Translator

Family Medicine

M-A: SGLT2 inhibitors reduce hospitalizations in patients with heart failure regardless of the presence of diabetes.

12 Apr, 2022 | 10:05h | UTC

Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: SGLT2 inhibitors reduces hospitalization for heart failure regardless of presence of diabetes – American College of Physicians

 

AHA Scientific Statement: SARS-CoV-2 infection and associated cardiovascular manifestations and complications in children and young adults.

12 Apr, 2022 | 09:59h | UTC

SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association – Circulation

News Release: Heart issues after COVID-19 uncommon in children and young adults, more research needed – American Heart Association

Commentary: COVID-19 CV Complications in Children Are Rare, Treatable: AHA Statement – TCTMD

 

Opinion | Aligning incentives for improving diagnostic excellence.

12 Apr, 2022 | 09:54h | UTC

Aligning Incentives for Improving Diagnostic Excellence – JAMA (free for a limited period)

 

Cohort Study: Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection.

12 Apr, 2022 | 09:57h | UTC

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

News Release: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Commentary: Older Kids More Vulnerable to MIS-C: Study – HealthDay

 

More data suggests the Omicron variant causes milder disease compared to the Delta variant.

12 Apr, 2022 | 09:49h | UTC

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study – The Lancet

Commentary: Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports – The BMJ

Related:

Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

 

COVID-19 disease severity in children infected with the Omicron variant.

12 Apr, 2022 | 09:47h | UTC

COVID-19 Disease Severity in Children Infected with the Omicron Variant – Clinical Infectious Diseases

Related: Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

 

Commentary on Twitter

 

Aspirin for primary cardiovascular prevention in patients with diabetes: uncertainties and opportunities.

12 Apr, 2022 | 08:45h | UTC

Aspirin for Primary Cardiovascular Prevention in Patients with Diabetes: Uncertainties and Opportunities – Thrombosis and Haemostasis

Related Guideline:

USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

 

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends.

11 Apr, 2022 | 02:01h | UTC

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends – National Institute for Health and Care Excellence

Commentaries:

Expert reaction to updated NICE draft guideline on weight management, including the suggestion for people to keep their waist measurement to less than half their height – Science Media Centre

Keep your waist to less than half your height, guidance says – BBC

Draft Guideline: Obesity: identification and classification of overweight and obesity – National Institute for Health and Care Excellence

 

Review: Atrial fibrillation.

11 Apr, 2022 | 01:57h | UTC

Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

UK clinical guideline for the prevention and treatment of osteoporosis.

11 Apr, 2022 | 01:33h | UTC

UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis

 

M-A: Effect of obesity treatment interventions in preschool children aged 2–6 years.

11 Apr, 2022 | 00:47h | UTC

Effect of obesity treatment interventions in preschool children aged 2–6 years: a systematic review and meta-analysis – BMJ Open

 

Cohort Study: Use of Phosphodiesterase 5 Inhibitors linked to increased risk of ocular adverse events.

8 Apr, 2022 | 11:04h | UTC

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US – JAMA Ophthalmology (free for a limited period)

News Release: U.S. insurance claims show strong link between ED medications and vision problems – University of British Columbia

Commentaries:

Phase 4 Studies on Phosphodiesterase 5 Inhibitors – JAMA Ophthalmology (free for a limited period)

Expert reaction to study looking at risk of vision impairment and loss, and use of phosphodiesterase type 5 inhibitors – Science Media Centre

Could Viagra, Cialis Raise Men’s Odds for Eye Trouble? – HealthDay

 

Long COVID in children: a modified Delphi process.

8 Apr, 2022 | 10:40h | UTC

Long COVID (post-COVID-19 condition) in children: a modified Delphi process – Archives of Disease in Childhood

Related:

First research definition for ‘Long COVID’ in kids and young people formally agreed.

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Review | Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies.

8 Apr, 2022 | 10:27h | UTC

Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies – BMJ Medicine

 

Putting positive experiences at the center of postnatal care.

8 Apr, 2022 | 10:34h | UTC

Putting positive experiences at the centre of postnatal care – Evidently Cochrane Blog

Original Guideline: WHO recommendations on maternal and newborn care for a positive postnatal experience.

 

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines?

8 Apr, 2022 | 10:00h | UTC

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines? – Clinical & Experimental Allergy

Original Guideline: EAACI guideline: Preventing the development of food allergy in infants and young children – Pediatric Allergy and Immunology

Related:

Practice Guideline: Prevention and management of allergic reactions to food in child care centers and schools

Study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)

Short Review: Food Allergy Prevention with Early Food Introduction

 

Autistic people are six times more likely to attempt suicide – poor mental health support may be to blame.

8 Apr, 2022 | 10:02h | UTC

Autistic people are six times more likely to attempt suicide – poor mental health support may be to blame – The Conversation

 

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice.

8 Apr, 2022 | 09:56h | UTC

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice – Internal and Emergency Medicine

Related:

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

Practice guidelines for office and out-of-office blood pressure measurement.

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

USPSTF Statement recommends screening for hypertension in adults 18 years or older with office blood pressure measurement – diagnostic confirmation with blood pressure measurements outside of the clinical setting is advised before starting treatment

Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements

 

Systematic Review: Approaches and outcomes of community health worker’s interventions for hypertension management and control in low-income and middle-income countries.

8 Apr, 2022 | 09:48h | UTC

Approaches and outcomes of community health worker’s interventions for hypertension management and control in low-income and middle-income countries: systematic review – BMJ Open

 

Study finds increased risk of pulmonary embolism up to 110 days after COVID-19.

7 Apr, 2022 | 10:06h | UTC

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

News Release: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Commentary: Covid: Blood clot risk higher for six months after having virus – BBC

 

M-A: Fluvoxamine for outpatient management of COVID-19 to prevent hospitalization.

7 Apr, 2022 | 09:55h | UTC

Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: Common Antidepressant Likely Cuts Risk Of Covid Hospitalization, Study Finds – Forbes

Related:

Short Review: Fluvoxamine for symptomatic outpatients with COVID-19.

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.

7 Apr, 2022 | 10:00h | UTC

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Related:

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Commentary on Twitter (thread – click for more)

 

Pragmatic RCT: In outpatients with Covid-19, the addition of pulse oximetry for monitoring did not improve outcomes compared to subjective assessments of dyspnea alone.

7 Apr, 2022 | 09:58h | UTC

Pulse Oximetry for Monitoring Patients with Covid-19 at Home — A Pragmatic, Randomized Trial – New England Journal of Medicine

 

Commentary on Twitter

 

Perspective | Studying severe long COVID to understand post-infectious disorders beyond COVID-19.

7 Apr, 2022 | 08:45h | UTC

Studying severe long COVID to understand post-infectious disorders beyond COVID-19 – Nature Medicine

Related:

Review: Post-acute COVID-19 syndrome.

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 

Commentary from the author on Twitter (thread – click for more)

 

RCT: Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anesthetic injection for hip osteoarthritis.

7 Apr, 2022 | 08:37h | UTC

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial – The BMJ

News Release: Steroid injections may provide longer lasting benefits for hip pain than current best care – BMJ

 

Commentary on Twitter

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.