Family Medicine
Cluster RCT: BABEL (Better tArgeting, Better outcomes for frail ELderly patients) advance care planning: a comprehensive approach to advance care planning in nursing homes.
19 Apr, 2022 | 01:26h | UTC
Endocrine therapies for breast and prostate cancers: Essentials for primary care.
19 Apr, 2022 | 01:14h | UTC
Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.
18 Apr, 2022 | 10:56h | UTCCommentaries:
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
An update on hepatitis cases in children:
We are continuing to investigate 74 cases of hepatitis (liver inflammation) in children in the UK since January 2022. 1/2
— UK Health Security Agency (@UKHSA) April 12, 2022
RCT: In patients with acute Achilles’ tendon rupture, a nonoperative strategy resulted in similar outcomes compared with routine surgical treatment.
18 Apr, 2022 | 10:53h | UTCNonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Heal Thyself: Most who tear Achilles tendon can skip surgery – Associated Press
Analysis: Changing the assortment of available food and drink for leaner, greener diets.
18 Apr, 2022 | 10:39h | UTCChanging the assortment of available food and drink for leaner, greener diets – The BMJ
News Release: Changing products on offer in shops and restaurants can lead to leaner, greener diets – BMJ
AHA Scientific Statement: Nonalcoholic fatty liver disease and cardiovascular risk.
18 Apr, 2022 | 10:37h | UTCNews Releases:
Fatty liver disease not caused by alcohol is common – and often missed – American Heart Association
Commentary: Loneliness and health.
18 Apr, 2022 | 10:16h | UTCLoneliness and health – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
The prevalence of loneliness across 113 countries: systematic review and meta-analysis – The BMJ
Social Isolation and Loneliness – World Health Organization
Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020 – JAMA
Commentary on Twitter
In this Comment, Louise Hawkley discusses associations of #Loneliness with increased mortality and disease risk, and that a multi-level approach including individuals, community organizations and society is needed to reduce loneliness.@NORCNewshttps://t.co/CzP5fR6G0n pic.twitter.com/X3use2Aybe
— Nature Reviews Disease Primers (@DiseasePrimers) April 14, 2022
An observational study in patients with chronic kidney disease suggests the optimum range of water intake is around 1–2 L/day.
18 Apr, 2022 | 10:12h | UTC
RCT: Among patients waiting for total knee arthroplasty with a BMI above 35, bariatric surgery before the procedure was associated with reduced risk of complications.
18 Apr, 2022 | 09:52h | UTCCommentary: Bariatric Surgery Before TKA Cuts Complications in Obese Patients – HealthDay
Commentary on Twitter
In this RCT, bariatric surgery before knee replacement (TKA) reduced the risk of complications in TKA in adults <65y with class II obesity scheduled to undergo TKA; 30% had sufficient symptom improvement to decline TKA altogether. https://t.co/qyhl0eIV2o
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
Study showed low rates of severe COVID-19 in children hospitalized with confirmed SARS-CoV-2 infection.
14 Apr, 2022 | 08:49h | UTCCommentary: Severe COVID-19 extremely rare among children – News Medical
Related:
COVID-19 disease severity in children infected with the Omicron variant.
Study identifies risk factors for severe CoviD-19 in children.
International study identifies predictors of severe outcomes in children with COVID-19.
RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.
14 Apr, 2022 | 08:43h | UTCEfficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
M-A: Association between physical activity and risk of depression.
14 Apr, 2022 | 08:35h | UTCCommentary: Exercise Is Powerful Medicine for Depression – HealthDay
Commentary on Twitter
Meta-analysis found that adults meeting physical activity recommendations had 25% lower risk of #depression compared with adults reporting no #physicalactivity. https://t.co/LITlo954lB
— JAMA Psychiatry (@JAMAPsych) April 13, 2022
Cross-sectional study: The use of Selective Serotonin Reuptake Inhibitors is associated with a reduction in measured movements.
14 Apr, 2022 | 08:32h | UTC
Commentary on Twitter
This cross-sectional study found SSRI use was associated with a reduction in measured movements, highlighting the utility of passively collected data for exploring and characterizing adverse drug effects. https://t.co/54ZngDdt8u
— JAMA Network Open (@JAMANetworkOpen) April 7, 2022
Population based cohort study: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia.
14 Apr, 2022 | 08:27h | UTCEditorial: Healthy lifestyles and more life years without dementia – The BMJ
Commentary on Twitter
A new US study suggests that a healthy lifestyle is associated with a longer life expectancy among both men and women, and they lived a larger proportion of their remaining years without Alzheimer’s diseasehttps://t.co/eXsQRd6mon
— The BMJ (@bmj_latest) April 14, 2022
M-A: Symptom burden and health-related quality of life in chronic kidney disease.
14 Apr, 2022 | 08:22h | UTC
USPSTF draft statement recommends screening for anxiety and depression in children and adolescents ages 8 to 18 years.
13 Apr, 2022 | 11:05h | UTCDraft Statements:
Screening for Anxiety in Children and Adolescents – US Preventive Services Task Force
Commentary:
USPSTF Recommends Anxiety, Depression Screening for Children – HealthDay
The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019.
13 Apr, 2022 | 11:03h | UTCInvited Commentary: The burden of young people’s mental health conditions in Europe: No cause for complacency – The Lancet Regional Health Europe
Related:
Commentary on Twitter
See our new @IHME_UW analysis from on the #burden of #mentaldisorders, substance use disorders & self-harm among young people in Europe. In 2019 there were 16,983 MDs cases/100.000. In last 30 yrs YLD for eating disorders & drug use disorders increased. https://t.co/hMbHDlPuur pic.twitter.com/Rt4Iq4tpAA
— Maciej Banach (@maciejbanach) April 2, 2022
(Article and images under a CC BY 4.0 license)
RCT: A home-based, walking exercise behavior change intervention increased walking distance in adults with peripheral artery disease.
13 Apr, 2022 | 11:02h | UTCEffect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this study, among adults with peripheral artery disease, a home-based, #walking #exercise behavior change intervention, compared with usual care, increased 6-minute walking distance at 3 months. https://t.co/5ea3YOWlN0 @LindsayBearne pic.twitter.com/s06ONnki9y
— JAMA (@JAMA_current) April 12, 2022
M-A: Sodium-glucose Cotransporter 2 inhibitors are associated with reduced risk of hyperkalemia in people with type 2 diabetes.
13 Apr, 2022 | 10:52h | UTC
RCT: Dapagliflozin did not significantly improve glycemic control in children and young adults with type 2 diabetes.
13 Apr, 2022 | 10:46h | UTCEfficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Review | Less is more: deprescribing medications in older adults with kidney disease.
13 Apr, 2022 | 10:44h | UTCLess is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Related:
AGA clinical practice update on de-prescribing of proton pump inhibitors.
Development of a metric to detect and decrease low-value prescribing in older adults.
Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.
A narrative review of evidence to guide deprescribing among older adults.
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan
Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
M-A: Adverse perinatal outcomes associated with protease inhibitor-based antiretroviral therapy in pregnant women living with HIV.
13 Apr, 2022 | 10:18h | UTCNews Release: Protease inhibitors safer than thought for pregnant women with HIV – University of Oxford
Drug resistant TB – latest developments in epidemiology, diagnostics and management.
13 Apr, 2022 | 10:09h | UTCRelated:
Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.
WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment
Canadian Tuberculosis Standards – 8th Edition.
Guideline: Treatment of Drug-Resistant Tuberculosis
The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis
Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives
Cohort Study: Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of the Pfizer vaccine in adolescents.
12 Apr, 2022 | 10:07h | UTC
RCT: Single-dose HPV vaccination found effective among young African women.
12 Apr, 2022 | 10:08h | UTCEfficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence
News Releases:
Study boosts support for single-dose HPV vaccine regimen – University of Washington
Related:
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
Commentary on Twitter (thread – click for more)
🚨 GAME CHANGER 🚨
One-dose Human Papillomavirus (#HPV) vaccine offers solid protection against cervical cancer: WHO https://t.co/3uWlZlCCVK pic.twitter.com/ZKDvpf2qog— World Health Organization (WHO) (@WHO) April 11, 2022