Family Medicine
WHO recommends highly successful COVID-19 therapy (nirmatrelvir-ritonavir) and calls for wide geographical distribution and transparency from originator.
22 Apr, 2022 | 09:36h | UTCSee also:
A living WHO guideline on drugs for covid-19 – The BMJ
Therapeutics and COVID-19: living guideline – World Health Organization
Related:
Commentary on Twitter
🔥 Our latest @WHO living guidance on drugs for #COVID19, with new recommendations for nirmatrelvir-ritonavir & updated recommendation for remdesivir in non-severe illness.@bmj_latest: https://t.co/KuJjwzeTPV@WHO: https://t.co/n3iQx3pdmY
@theMAGICapp: https://t.co/dA7YYzeAZ1 pic.twitter.com/LvAhJf70UY
— Arnav Agarwal (@ArnavAgarwalMD) April 21, 2022
CDC alerts providers to hepatitis cases of unknown origin.
22 Apr, 2022 | 09:34h | UTCCommentaries:
CDC issues health advisory about acute hepatitis in children – CNN
CDC Issues Alert for Hepatitis in Children With Adenovirus Infection – WebMD
Related:
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
UK drug regulator advises patients and doctors against the use of Pregabalin during pregnancy due to a possible increased risk of congenital malformations.
22 Apr, 2022 | 09:31h | UTCSee also: Pregabalin and risks in pregnancy – Medicines and Healthcare products Regulatory Agency
Source: Avoid prescribing pregabalin during pregnancy if possible, says UK drug regulator – The BMJ ($)
Commentary on Twitter
The Medicines and Healthcare Products Regulatory Agency (@MHRAgovuk) has strengthened its warning about avoiding pregabalin during pregnancy after new data showed an increased risk of major congenital malformations associated with the drug https://t.co/ghGvqCqA0C
— The BMJ (@bmj_latest) April 22, 2022
RCT: Calorie restriction combined with time-restricted eating (eating from 8:00 am to 4:00 pm) did not significantly decrease weight loss compared to calorie restriction alone at 12 months (net difference, −1.8 kg; 95% CI, −4.0 to 0.4; P=0.11).
21 Apr, 2022 | 10:31h | UTCCalorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Time-Restricted Eating No Better Than Cutting Calories for Obesity – HealthDay
Commentary on Twitter
As compared with calorie restriction, time-restricted eating does not produce additional benefits with regard to reduction of body weight, body fat, and metabolic risk factors. https://t.co/Ygx4zbC6QP pic.twitter.com/TGE5Pva3yS
— NEJM (@NEJM) April 20, 2022
Vitamin D supplements in pregnancy: what’s the latest evidence?
21 Apr, 2022 | 09:58h | UTCVitamin D supplements in pregnancy: what’s the latest evidence? – Evidently Cochrane Blog
Original Study: Vitamin D supplementation for women during pregnancy – Cochrane Library
USPSTF Draft Statement: Postmenopausal women should not use hormone therapy to prevent chronic health problems.
20 Apr, 2022 | 10:15h | UTCDraft Recommendation Statement: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons – U.S. Preventive Services Task Force
Commentary: USPSTF Advises Against Hormone Therapy to Prevent Chronic Conditions – HealthDay
Studies highlight meningitis vaccine’s potential against gonorrhea.
20 Apr, 2022 | 10:06h | UTCCommentary: Studies highlight meningitis vaccine’s potential against gonorrhea – CIDRAP
News Release: Threat of untreatable gonorrhoea could be tackled using an existing meningitis vaccine – The Lancet
Study 1: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Study 2: Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
An observational study suggests coprescription of Phosphodiesterase Type 5 Inhibitors (i.e., sildenafil) and oral Nitrates is not associated with increased risk of adverse cardiovascular outcomes in male patients with ischemic heart disease.
20 Apr, 2022 | 10:11h | UTCCommentaries:
PDE5 Inhibitors Prescribed for Men on Oral Nitrates for IHD – HealthDay
Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel.
20 Apr, 2022 | 09:57h | UTCCovid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel – STAT
FDA warns of risks associated with non-invasive prenatal screening tests – inappropriate interpretation of results may lead to potentially improper medical decisions.
20 Apr, 2022 | 09:52h | UTC
German guidelines for the diagnosis and treatment of varicose veins.
20 Apr, 2022 | 09:49h | UTCS2k guidelines: diagnosis and treatment of varicose veins – Leitlinien und Empfehlungen
Systematic Review: Treatment of periodontitis for glycemic control in people with diabetes mellitus.
20 Apr, 2022 | 09:36h | UTCTreatment of periodontitis for glycaemic control in people with diabetes mellitus – Cochrane Library
Commentary on Twitter
Does treatment for gum disease help people with diabetes control their blood sugar levels? Evidence from @CochraneLibrary: https://t.co/lk6nGrAIpp pic.twitter.com/UZXKr5b4Rs
— Cochrane Oral Health (@CochraneOHG) April 19, 2022
Cohort Study: Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland.
20 Apr, 2022 | 09:22h | UTC
Commentary on Twitter
Very sobering study based on Scottish data. Children and young people with intellectual disability are at far higher risk of death and are more likely to have an avoidable death – one amenable to timely, effective care. https://t.co/xuxYjVrRd8
— Mary Dixon-Woods (@MaryDixonWoods) April 16, 2022
National, regional, and global estimates of anemia by severity in women and children for 2000–19.
20 Apr, 2022 | 09:25h | UTCInvited Commentary: Sustainable Development Goals for anaemia: 20 years later, where are we now? – The Lancet Global Health
Cohort Study: Association of subjective memory complaints with white matter hyperintensities and cognitive decline among older adults.
20 Apr, 2022 | 09:17h | UTCCommentary: Memory complaints associated with structural brain abnormalities and increased dementia risk – HealthImaging
Commentary on Twitter
In this cohort study, subjective memory complaints (SMCs) were associated with larger white matter hyperintensity volumes and faster cognitive decline, suggesting that SMCs are an important sign of cognitive impairment. https://t.co/mpCXDbylnf
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
M-A: Invasive group A streptococcal disease in pregnant women and young children.
20 Apr, 2022 | 09:05h | UTCInvited Commentary: Recognising group A streptococcal disease in pregnancy – The Lancet Infectious Diseases (free registration required)
Review: Preterm premature rupture of membranes – inpatient versus outpatient management.
20 Apr, 2022 | 09:06h | UTC
Opinion | Low-grade prostate cancer (Gleason score 6): time to stop calling it cancer.
19 Apr, 2022 | 02:29h | UTCLow-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology
Commentary: Doctors suggest new names for low-grade prostate cancer – Associated Press
M-A: Global prevalence of post COVID-19 condition or long COVID.
19 Apr, 2022 | 02:18h | UTCCommentary: Global data reveal half may have long COVID 4 months on – CIDRAP
Commentary on Twitter (thread – click for more)
🚨The so far largest meta-analysis of more than 1.5 million infected individuals puts the global prevalence of #LongCovid at 43%. Some additional key findings. 🧵https://t.co/XGu23MV3Ra
1/— Jonas R. Kunst (@kunstjonas.bsky.social) (@KunstJonas) April 17, 2022
Opinion | Learning the art and science of diagnosis.
19 Apr, 2022 | 02:12h | UTCLearning the Art and Science of Diagnosis – JAMA (free for a limited period)
RCT: Allopurinol is noninferior to febuxostat for controlling gout flares.
19 Apr, 2022 | 02:05h | UTCComparative Effectiveness of Allopurinol and Febuxostat in Gout Management – NEJM Evidence (link to abstract – $ for full-text)
Cohort Study: Association of treatment with antipsychotics, antidepressants, or both with movement disorders and seizures among children and adolescents with depression.
19 Apr, 2022 | 01:50h | UTC
Commentary on Twitter
In this cohort study, adjunctive antipsychotics with antidepressants were associated with movement disorders and seizures compared with antidepressant monotherapy in children and adolescents with depression. https://t.co/3SVKEThwkR
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
Review: Paradoxical reactions to biologicals in chronic inflammatory systemic diseases.
19 Apr, 2022 | 01:48h | UTC
Review: The safety of antirheumatic drugs.
19 Apr, 2022 | 01:42h | UTCThe Safety of Antirheumatic Drugs – Deutsches Ärzteblatt International
Palliative care for older people with dementia—we need a paradigm shift in our approach – “Advance care planning (ACP) is a central tenet of good dementia palliative care”.
19 Apr, 2022 | 01:30h | UTC