Family Medicine | Page 60 of 374 | Links Medicus Content Curation & Alerts in Medicine

❓ What is the effectiveness and safety of luteal support for those trying to conceive by intrauterine insemination #IUI or by sexual intercourse?
New @CochraneCGF systematic review looks at the evidence from 25 RCTs involving 5,111 participants. https://t.co/jjsetCMo3E pic.twitter.com/tWNtGx8rdC

— The Cochrane Library (@CochraneLibrary) September 2, 2022

Systematic Review | Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use.

2 Sep, 2022 | 13:07h | UTC

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use – Cochrane Library

Review | Covid-19 vaccines — immunity, variants, boosters.

1 Sep, 2022 | 11:57h | UTC

Covid-19 Vaccines — Immunity, Variants, Boosters – New England Journal of Medicine

Cohort Study | Dolutegravir in pregnancy as compared with current HIV regimens.

1 Sep, 2022 | 11:55h | UTC

Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States – New England Journal of Medicine (link to abstract – $ for full-text)

RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

Commentary on Twitter

In this study involving 1257 pregnancies among persons treated for HIV-1 infection during pregnancy, dolutegravir was better at suppressing viral loads than other regimens, without evident safety concerns. https://t.co/CnShoao995 pic.twitter.com/Qne24I1482

— NEJM (@NEJM) August 31, 2022

Reports of asymptomatic monkeypox suggest that, at the very least, some infections go unnoticed.

1 Sep, 2022 | 11:54h | UTC

Reports of Asymptomatic Monkeypox Suggest That, at the Very Least, Some Infections Go Unnoticed – JAMA

RCT | Placement of an intrauterine device within 48 hours after early medical abortion.

1 Sep, 2022 | 11:51h | UTC

Placement of an intrauterine device within 48 hours after early medical abortion – a randomized controlled trial – American Journal of Obstetrics & Gynecology

Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.

1 Sep, 2022 | 11:46h | UTC

Zinc for the prevention or treatment of respiratory tract infections: A new systematic review – Science-Based Medicine

Original Study: M-A: Zinc might help to stave off respiratory infection symptoms and cut illness duration – “But quality of evidence variable, and no clarity on optimal formulation or dose”.

Meta-analysis of observational studies | Leisure activities and the risk of dementia.

1 Sep, 2022 | 11:44h | UTC

Leisure Activities and the Risk of Dementia: A Systematic Review and Meta-Analysis – Neurology

News Release: Which Leisure Activities Are Linked to Lower Risk of Dementia? – American Academy of Neurology

Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.

1 Sep, 2022 | 11:43h | UTC

News Release: Dentists should give antibiotics to high-risk patients to help prevent life-threatening heart infection – The University of Sheffield

Original Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian

Meta-analysis of randomized trials | Antibiotic therapy vs. appendicectomy for uncomplicated acute appendicitis.

1 Sep, 2022 | 11:40h | UTC

Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis – BJS Open

Nonoperative vs Operative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis – JAMA Surgery

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

Commentary on Twitter

👼 The reborn of surgery for uncomplicated acute appendicitis ?!

🧐 RCT comparing antibiotic 🤜🤛 appendicectomy: meta analysis of > 3000 patients

💊 No benefit on complications and LOS

🏥 Antibiotics 6X increase in hospital readmission!

🆓 full text https://t.co/VhL9u0Weua pic.twitter.com/SdyK0rKS3f

— Giovanni Marchegiani (@Gio_Marchegiani) August 17, 2022

Guideline | Fecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer.

31 Aug, 2022 | 11:52h | UTC

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) – Gut

Commentary: Guidelines update: use of FIT in colorectal cancer referrals – PULSE

Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.

31 Aug, 2022 | 11:51h | UTC

Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta-blockers is not justified – Blood Pressure

RCT | Remote physician visits are noninferior to in-home physician visits for patients receiving acute hospital-level care at home (home hospital).

31 Aug, 2022 | 11:49h | UTC

Remote vs In-home Physician Visits for Hospital-Level Care at Home: A Randomized Clinical Trial – JAMA Network Open

Author Interview: Remote vs In-home Physician Visits for Hospital-Level Care at Home – JAMA

Commentary on Twitter

Home hospital care is scaling fast, but the role for remote MD care is unknown. In this #RCT, remote MD care was noninferior to in-home MD care, but in-home MD care was critical to 1 in 5 patients. @hahusersgroup @WHAH_cong #OpenAccess #Research https://t.co/ZoE4oc37jx

— JAMA Network Open (@JAMANetworkOpen) August 30, 2022

Guideline | Management of preschool wheezing.

31 Aug, 2022 | 11:37h | UTC

Management of Preschool Wheezing: Guideline from the Emilia-Romagna Asthma (ERA) Study Group – Journal of Clinical Medicine

Relationship between maternal caffeine and coffee intake and pregnancy loss: a grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies.

31 Aug, 2022 | 11:35h | UTC

Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies – Frontiers in Nutrition

Cluster RCT | Effect of different interventions to help primary care clinicians avoid unsafe opioid prescribing in opioid-naive patients with acute noncancer pain.

31 Aug, 2022 | 11:33h | UTC

Effect of Different Interventions to Help Primary Care Clinicians Avoid Unsafe Opioid Prescribing in Opioid-Naive Patients With Acute Noncancer Pain: A Cluster Randomized Clinical Trial – JAMA Health Forum

Commentary on Twitter

This cluster randomized clinical trial found that clinician comparison email feedback had the potential to decrease harm from opioid prescriptions for acute noncancer pain. @RxEricWright @walidgellad #VisualAbstract https://t.co/BizLH13lau pic.twitter.com/EEbdqWRqig

— JAMA Health Forum (@JAMAHealthForum) July 29, 2022

Cohort Study | Association of leisure time physical activity types and risks of all-cause, cardiovascular, and cancer mortality among older adults.

31 Aug, 2022 | 11:29h | UTC

Association of Leisure Time Physical Activity Types and Risks of All-Cause, Cardiovascular, and Cancer Mortality Among Older Adults – JAMA Network Open

News Release: Many types of leisure time activities may lower risk of death for older adults – NIH News Releases

Commentaries:

Want to lower your risk of early death? 3 activities are most beneficial, study says – CNN

Any Type of Leisure-Time Physical Activity Tied to Lower Mortality Risk – HealthDay

Commentary on Twitter

All types of leisure time physical activities (running, cycling, swimming, aerobic exercise, racket sports, golf, and exercise walking) are associated with lower risks of mortality for people aged 59-82 years. #OAResearch https://t.co/wkunjzOeYo

— JAMA Network Open (@JAMANetworkOpen) August 24, 2022