Open access
Open access
Powered by Google Translator Translator

Family Medicine

#ESCCongress – RCT: Finerenone reduced CV events in patients with kidney disease and type 2 diabetes (12.4% vs. 14.2% during a median follow-up of 3.4 years), but the risk of hyperkalemia was increased (10.8% vs. 5.3%).

29 Aug, 2021 | 18:14h | UTC

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes – New England Journal of Medicine

News release: Finerenone benefits patients with diabetes across spectrum of kidney disease – European Society of Cardiology

Commentaries:

Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease – FIGARO-DKD – American College of Cardiology

FIGARO-DKD and FIDELITY Findings Show Benefits of Finerenone to Improve Outcomes in Patients With Kidney Disease, Diabetes – American College of Cardiology

Related:

[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes

 

Commentary on Twitter

 

#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

29 Aug, 2021 | 18:11h | UTC

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology

 

#ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).

29 Aug, 2021 | 18:08h | UTC

Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

News release: Screening for atrial fibrillation could reduce risk of stroke – Karolinska Institutet

 

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.

27 Aug, 2021 | 10:18h | UTC

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols – University of California – San Diego

Original article: Airborne transmission of respiratory viruses – Science

 

Commentary on Twitter (thread – click for more)

 

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

27 Aug, 2021 | 10:11h | UTC

Press release: Is COVID vaccine protection fading? – ZOE Covid Study

Commentaries:

Covid infection protection waning in double jabbed – BBC

Expert reaction to press release from the ZOE app on vaccine effectiveness over time – Science Media Centre

 

Cohort study: Most COVID-19 hospital survivors had a good physical and functional recovery after 1 year of follow-up, but around half of the patients had at least one sequelae symptom.

27 Aug, 2021 | 10:13h | UTC

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study – The Lancet

Editorial: Understanding long COVID: a modern medical challenge – The Lancet

Related:

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

New guidelines to help doctors manage long COVID patients published.

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

 

[Preprint] Observational data suggests natural immunity after a SARS-CoV-2 infection confers longer lasting and stronger protection compared to vaccine-induced immunity.

27 Aug, 2021 | 10:16h | UTC

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections – medRxiv

Commentary: Having SARS-CoV-2 once confers much greater immunity than a vaccine—but no infection parties, please – Science

 

Commentary on Twitter (thread – click for more)

https://twitter.com/andrew_croxford/status/1430799815693250562

 

Covid-19 vaccines flirted with perfection at first. Reality is more complicated.

27 Aug, 2021 | 10:05h | UTC

Covid-19 vaccines flirted with perfection at first. Reality is more complicated – STAT

 

Commentary on Twitter

 

The Lancet Series: Active ingredients for addressing youth anxiety and depression.

27 Aug, 2021 | 09:05h | UTC

Homepage: Active ingredients for addressing youth anxiety and depression – The Lancet Psychiatry (free registration required for all articles)

The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

See commentary: The benefits and harms of antidepressants for youth depression and anxiety #ActiveIngredientsMH – The Mental Elf

Circadian rhythm sleep–wake disturbances and depression in young people: implications for prevention and early intervention

Harnessing emotional mental imagery to reduce anxiety and depression in young people: an integrative review of progress and promise

Identifying and integrating active ingredients for mental health

 

Commentary on Twitter

https://twitter.com/TheLancetPsych/status/1428692894165225473

 

Review: How to approach a patient with difficult-to-treat IBS.

27 Aug, 2021 | 09:00h | UTC

How to Approach a Patient with Difficult-to-Treat IBS – Gastroenterology (free for a limited period)

 

Commentary on Twitter

 

Exposure to antipsychotics in womb not found to increase risk of ADHD, autism in offspring.

27 Aug, 2021 | 09:03h | UTC

Exposure to Antipsychotics in Womb Not Found to Increase Risk of ADHD, Autism in Offspring – Psychiatric News Alert

Original study: Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age – JAMA Internal Medicine

Author interview: Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age

 

A review of the epidemiology, pathophysiology, and efficacy of anti-diabetic drugs used in the treatment of nonalcoholic fatty liver disease.

27 Aug, 2021 | 08:59h | UTC

A Review of the Epidemiology, Pathophysiology, and Efficacy of Anti-diabetic Drugs Used in the Treatment of Nonalcoholic Fatty Liver Disease – Digestive Diseases and Sciences

 

Revisiting treatment options for depressed patients with generalized anxiety disorder.

27 Aug, 2021 | 08:52h | UTC

Revisiting Treatment Options for Depressed Patients with Generalised Anxiety Disorder – Advances in Therapy

 

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

26 Aug, 2021 | 09:16h | UTC

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting – New England Journal of Medicine

Commentaries on Twitter

(thread from the author – click for more)

 

WHO Guide | Support for rehabilitation: self-management after COVID-19-related illness.

26 Aug, 2021 | 09:21h | UTC

Support for rehabilitation: self-management after COVID-19-related illness, 2nd ed. – World Health Organization

 

Commentary on Twitter

 

COVID vaccines show no signs of harming fertility or sexual function.

26 Aug, 2021 | 09:12h | UTC

COVID Vaccines Show No Signs of Harming Fertility or Sexual Function – Scientific American

Related: Study: Sperm parameters not changed before and after COVID-19 mRNA vaccination.

 

Pregnant women do well with COVID vaccine, survey finds.

26 Aug, 2021 | 09:03h | UTC

Pregnant women do well with COVID vaccine, survey finds – University of Washington School of Medicine/UW Medicine

Original study: Short-term Reactions Among Pregnant and Lactating Individuals in the First Wave of the COVID-19 Vaccine Rollout – JAMA Network Open

Related: CDC Guidance: Pregnant people should be vaccinated against COVID-19.

 

Commentary on Twitter

 

Johnson & Johnson booster shot prompts large increase in immune response, company says.

26 Aug, 2021 | 09:14h | UTC

Johnson & Johnson booster shot prompts large increase in immune response, company says – CNN

News release: Johnson & Johnson Announces Data to Support Boosting its Single-Shot COVID-19 Vaccine

 

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

26 Aug, 2021 | 09:05h | UTC

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy – Self

Related: CDC Guidance: Pregnant people should be vaccinated against COVID-19.

 

Commentary on Twitter

 

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

26 Aug, 2021 | 08:59h | UTC

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease – The Lancet Respiratory Medicine

Invited commentary: Charting a course for the management of long COVID

Related: M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Commentary on Twitter

 

New guidelines to help doctors manage long COVID patients published.

26 Aug, 2021 | 09:01h | UTC

New guidelines to help doctors manage long COVID patients published – Imperial College London

Original article: Recommendations for the recognition, diagnosis, and management of long covid: A Delphi study – British Journal of General Practice

Related: M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

New WHO Guideline for the pharmacological treatment of hypertension in adults.

26 Aug, 2021 | 08:57h | UTC

Guideline for the pharmacological treatment of hypertension in adults – World Health Organization

Related: WHO: More than 700 million people with untreated hypertension – Number of people living with hypertension has doubled to 1.28 billion since 1990.

 

Commentary on Twitter (thread – click for more)

 

WHO: More than 700 million people with untreated hypertension – Number of people living with hypertension has doubled to 1.28 billion since 1990.

26 Aug, 2021 | 08:54h | UTC

More than 700 million people with untreated hypertension – World Health Organization

Original study: Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

 

Commentary on Twitter (thread – click for more)

 

Expert analysis: Ideal Aspirin Dose for Secondary Prevention in Patients with ASCVD – “A lower-dose aspirin strategy is best for most patients with ASCVD given similar effectiveness, bleeding risk, and overall better adherence”.

26 Aug, 2021 | 08:42h | UTC

Ideal Aspirin Dose for Secondary Prevention in Patients With ASCVD – American College of Cardiology

Related: #ACC21 – RCT: No significant differences in cardiovascular events or major bleeding between patients receiving 81 mg vs. 325 mg of aspirin daily.

 

CDC Report: Unvaccinated 5 times more likely to get COVID-19 and 29 times more likely to be hospitalized than vaccinated individuals.

25 Aug, 2021 | 09:56h | UTC

SARS-CoV-2 Infections and Hospitalizations Among Persons Aged ≥16 Years, by Vaccination Status — Los Angeles County, California, May 1–July 25, 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: CDC: Unvaccinated 5 times more likely to get COVID-19 – CIDRAP

 

Commentary on Twitter

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.