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[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.

1 Sep, 2021 | 09:59h | UTC

BNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv

 

Why is a third COVID-19 vaccine dose important for people who are immunocompromised?

1 Sep, 2021 | 09:57h | UTC

Why is a third COVID-19 vaccine dose important for people who are immunocompromised? – The Conversation

Related:

FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.

RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

 

COVID may be most infectious 2 or 3 days around symptom onset.

1 Sep, 2021 | 09:51h | UTC

COVID may be most infectious 2 or 3 days around symptom onset – CIDRAP

Original article: COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19: A Population-Based Cohort Study in Zhejiang Province, China – JAMA Internal Medicine

 

AGA clinical practice update on the diagnosis and management of atrophic gastritis.

1 Sep, 2021 | 09:45h | UTC

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review – Gastroenterology

 

Commentary on Twitter

 

NICE Guideline: Assessment and management of chronic kidney disease.

1 Sep, 2021 | 09:47h | UTC

Chronic kidney disease: assessment and management – National Institute for Health and Care Excellence

 

Study shows that current definitions of chronic kidney disease overestimate the CKD burden in older individuals and results in overdiagnosis.

1 Sep, 2021 | 09:43h | UTC

Accounting for Age in the Definition of Chronic Kidney Disease – JAMA Internal Medicine (free for a limited period)

Invited commentary: Overdiagnosis of Chronic Kidney Disease in Older Adults—An Inconvenient Truth – JAMA Internal Medicine (free for a limited period)

 

Commentary on Twitter

 

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.

1 Sep, 2021 | 09:04h | UTC

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management – Mayo Clinic Proceedings

 

Study shows young children gained weight during the pandemic.

31 Aug, 2021 | 08:59h | UTC

News release: Young children gained weight during the pandemic – Kaiser Permanente

Original study: Changes in Body Mass Index Among Children and Adolescents During the COVID-19 Pandemic – JAMA

 

Commentary on Twitter

 

Study demonstrates a significantly higher humoral immunogenicity induced by the SARS-CoV-2 Moderna vaccine compared with the Pfizer- BioNTech vaccine.

31 Aug, 2021 | 09:04h | UTC

Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273 – JAMA

Related:

Moderna may be superior to Pfizer against Delta variant — breakthrough odds rise with time.

[Preprint] Pfizer vs. Moderna COVID-19 vaccine effectiveness against the Delta variant in Qatar – Effectiveness against symptomatic disease due to Delta was 53.5% for Pfizer and 84.8% for Moderna; effectiveness against severe disease due to Delta was 89.7% for Pfizer and 100.0% for Moderna.

 

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

31 Aug, 2021 | 08:57h | UTC

Do kids get long COVID? And how often? A paediatrician looks at the data – The Conversation

Related:

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

31 Aug, 2021 | 08:53h | UTC

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC) – European Heart Journal

News release: How can I avoid heart disease or stroke? – European Society of Cardiology

Key Points: 2021 ESC Guidelines on CVD Prevention in Clinical Practice – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT: Influenza vaccination early after a myocardial infarction (MI) or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis compared with placebo.

31 Aug, 2021 | 08:52h | UTC

Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial – Circulation

Commentaries:

IAMI: Influenza Vaccine Beneficial for Post-MI Patients – TCTMD

Influenza Vaccination After Myocardial Infarction – IAMI – American College of Cardiology

Flu vaccine after heart attack reduces risk of death – Cardiovascular Business

 

Commentary on Twitter

 

#ESCCongress – RCT: In older patients with hypertension, intensive treatment with a SBP target of 110 to less than 130 mm Hg resulted in a lower incidence of cardiovascular events than standard treatment with a target of 130 to less than 150 mm Hg.

31 Aug, 2021 | 08:49h | UTC

Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

STEP: Aggressive BP Management in Older Chinese Patients With HTN Improved CV Outcomes vs. Standard Care – American College of Cardiology

STrategy of blood pressure intervention in the Elderly hypertensive Patients – STEP – American College of Cardiology

 

Commentary on Twitter

 

#ESCCongress – RCT: In individuals at risk for stroke, screening for atrial fibrillation using loop recorder resulted in a three-times increase in atrial fibrillation detection and anticoagulation initiation but did not reduce the risk of stroke or systemic arterial embolism.

31 Aug, 2021 | 08:50h | UTC

Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial – The Lancet

News release: Continuous heart rhythm monitoring and treatment if indicated does not prevent stroke – European Society of Cardiology

Commentary: Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder to Prevent Stroke in High-Risk Individuals – LOOP – American College of Cardiology

Related: #ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).

 

Study with over 29 million people in England shows Covid-19, not vaccination, presents biggest blood clot risks.

29 Aug, 2021 | 18:57h | UTC

Press release: Covid-19, not vaccination, presents biggest blood clot risks – University of Oxford

Original study: Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study – The BMJ

Editorial: Strengthening international surveillance of vaccine safety – The BMJ

Commentaries:

Expert reaction to study looking at risk of thrombocytopenia and thromboembolism after COVID-19 vaccination and SARS-CoV-2 infection – Science Media Centre

Covid: Vaccine complications dwarfed by virus risks – BBC

 

Commentary on Twitter

 

#ESCCongress – M-A: Polypills with and without aspirin substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularization, and cardiovascular death in primary cardiovascular disease prevention.

31 Aug, 2021 | 08:47h | UTC

Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentary: Combo therapy cuts risk of heart attacks and strokes in half – McMaster University

Related:

Opinion: A new important study supports wider use of the polypill

#AHA20 – Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk

Perspective: Are Polypills and Population-based Treatment the Next Big Things?

The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era

Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population

Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases

Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart

Perspective: The Polypill and the Long Journey to Major Impact

Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care

 

Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.

29 Aug, 2021 | 19:02h | UTC

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study – The Lancet Infectious Diseases

Commentaries:

Importance of epidemiological factors in the evaluation of transmissibility and clinical severity of SARS-CoV-2 variants – The Lancet Infectious Diseases

Covid: Delta variant patients twice as likely to need hospital care – BBC

Covid-19 hospitalization risk doubles with Delta variant, UK study suggests – CNN

Expert reaction to study looking at risk of hospitalisation from the delta variant compared with alpha – Science Media Centre

 

Commentary on Twitter

 

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes – An HbA1c < 6.5% measured at least 3 months after cessation of glucose-lowering pharmacotherapy is suggested as the usual diagnostic criteria.

31 Aug, 2021 | 08:45h | UTC

Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes – The Journal of Clinical Endocrinology & Metabolism

News release: International Experts Outline Diabetes Remission Diagnosis Criteria – Endocrine Society

 

Many predicted some kind of ‘Covid slide’ in learning. Test results show how bad it is.

29 Aug, 2021 | 18:55h | UTC

Many predicted some kind of ‘Covid slide’ in learning. Test results show how bad it is – CNN

Report: Learning during COVID-19: Reading and math achievement in the 2020-21 school year – NWEA

Related:

[Preprint] Impact of the COVID-19 pandemic on early child cognitive development: initial findings in a longitudinal observational study of child health.

 

Unvaccinated, unmasked teacher infected more than half of students in class with Covid-19, CDC reports.

29 Aug, 2021 | 18:52h | UTC

Unvaccinated, unmasked teacher infected more than half of students in class with Covid-19, CDC reports – CNN

Original study: Outbreak Associated with SARS-CoV-2 B.1.617.2 (Delta) Variant in an Elementary School — Marin County, California, May–June 2021 – CDC Morbidity and Mortality Weekly Report

 

M-A: Factors associated with household transmission of SARS-CoV-2 – recent studies showed higher household secondary attack rates than earliest reports (13.4% vs. 31.1%); more transmissible variants and vaccines may lead to further changes.

29 Aug, 2021 | 18:48h | UTC

Factors Associated With Household Transmission of SARS-CoV-2: An Updated Systematic Review and Meta-analysis – JAMA Network Open

Commentary: 1 in 5 people with COVID-19 pass it to others in household, study finds – UPI

 

Commentary on Twitter

 

New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”

29 Aug, 2021 | 18:51h | UTC

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021–22 Influenza Season – Centers for Disease Control and Prevention

Related: Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Authorized in the United States – Centers for Disease Control and Prevention

Commentary: Flu shot and a COVID jab? New 2021-2022 flu vaccine guidance points to both – McKnight’s

 

#ESCCongress – 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure – SGLT2 inhibitors are now recommended for patients with heart failure with reduced ejection fraction regardless of the presence of diabetes.

29 Aug, 2021 | 18:25h | UTC

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC – European Heart Journal

News release: ESC Guidelines on heart failure management launched today – European Society of Cardiology

 

Commentary on Twitter

 

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

29 Aug, 2021 | 19:21h | UTC

Effect of Salt Substitution on Cardiovascular Events and Death – New England Journal of Medicine (link to abstract – $ for full-text)

News release: Low-sodium salt prevents stroke – European Society of Cardiology

Commentary: Massive SSaSS Study Shows Switch to Salt Substitute Cuts Stroke, CVD – TCTMD

 

Commentary on Twitter

 

#ESCCongress – RCT: SGLT2 inhibition reduced the combined risk of cardiovascular death or hospitalization in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

29 Aug, 2021 | 18:19h | UTC

Empagliflozin in Heart Failure with a Preserved Ejection Fraction – New England Journal of Medicine

News release: Trial reports first successful results for heart failure with preserved ejection fraction – European Society of Cardiology

Commentary: Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction – EMPEROR-Preserved – American College of Cardiology

 

Commentary on Twitter

 

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