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What we actually know about the vaccines and the delta variant – “Covid-19 vaccines still are effective in preventing hospitalization. But vaccinated people are more likely to get sick than before”.

25 Aug, 2021 | 09:09h | UTC

What we actually know about the vaccines and the delta variant – Vox

 

CDC Report: Vaccine effectiveness dropped from 91% to 66% since the SARS-CoV-2 Delta variant became predominant.

25 Aug, 2021 | 09:11h | UTC

Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance — Eight U.S. Locations, December 2020–August 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

Vaccines are less protective against Delta infection but still reduce risk by two-thirds, US CDC study shows – CNN

Messenger RNA COVID vaccines 66% effective against Delta: US study – Associated Press

 

Perspective | Delta has changed the pandemic risk calculus – “If you’re confused about what you can do right now, you should be”.

25 Aug, 2021 | 09:05h | UTC

Delta Has Changed the Pandemic Risk Calculus – The Atlantic

 

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

25 Aug, 2021 | 08:59h | UTC

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI) – Insights into Imaging

Related:

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance

2 Case Series and Guidance| Lymphadenopathy in COVID-19 Vaccine Recipients

COVID-19 vaccine-linked adenopathies could mimic breast malignancies

 

Third Pfizer dose 86% effective in over 60s, Israeli HMO says.

25 Aug, 2021 | 09:01h | UTC

Third Pfizer dose 86% effective in over 60s, Israeli HMO says – Reuters

 

Commentary on Twitter

 

Systematic review: The impact of COVID-19 lockdown on child and adolescent mental health.

25 Aug, 2021 | 08:58h | UTC

The impact of COVID-19 lockdown on child and adolescent mental health: systematic review – European Child & Adolescent Psychiatry

Related: M-A: Child and youth mental health problems have doubled during COVID-19. (several articles on the subject)

 

Review: Acute and chronic hyponatremia.

25 Aug, 2021 | 08:50h | UTC

Acute and Chronic Hyponatremia – Frontiers in Medicine

Related:

Randomized trial suggests rapid intermittent bolus of hypertonic saline is the best approach for the treatment of symptomatic hyponatremia

Podcast: Hyponatremia deconstructed

Diagnosis and Management of Disorders of Body Tonicity—Hyponatremia and Hypernatremia: Core Curriculum 2020 – American Journal of Kidney Diseases

Guidelines for the Management of Exercise-Associated Hyponatremia

 

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

25 Aug, 2021 | 08:56h | UTC

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants – The Lancet

Commentary: Global and national high blood pressure burden and control – The Lancet (free registration required)

 

Commentary on Twitter

 

New USPSTF statement recommends overweight and obese individuals should undergo screening for Prediabetes and Type 2 Diabetes at age 35 instead of 40.

25 Aug, 2021 | 08:54h | UTC

Final Recommendation Statement: Screening for Prediabetes and Type 2 Diabetes – U.S. Preventive Services Task Force

Editorials:

New USPSTF Recommendations for Screening for Prediabetes and Type 2 Diabetes: An Opportunity to Create National Momentum – JAMA

Updated USPSTF Screening Recommendations for Diabetes: Identification of Abnormal Glucose Metabolism in Younger Adults – JAMA Internal Medicine

Author interview: USPSTF Recommendation: Screening for Prediabetes and Type 2 Diabetes – JAMA

Evidence report: Screening for Prediabetes and Type 2 Diabetes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

JAMA Patient Page: Screening for Prediabetes and Type 2 Diabetes

 

RCT: No effect of Vitamin D supplementation on kidney function in adults with prediabetes.

25 Aug, 2021 | 08:41h | UTC

Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Things we do for no reason: tumor markers CA125, CA19-9, and CEA in the initial diagnosis of malignancy.

25 Aug, 2021 | 08:42h | UTC

Things We Do for No Reason™: Tumor Markers CA125, CA19-9, and CEA in the Initial Diagnosis of Malignancy – Journal of Hospital Medicine

 

Preventing stillbirth: What’s the latest evidence?

25 Aug, 2021 | 08:38h | UTC

Preventing stillbirth: What’s the latest evidence? – Evidently Cochrane

Special collection: Stillbirth prevention and respectful bereavement care – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

Covid-19 booster vaccines: What we know and who’s doing what.

24 Aug, 2021 | 10:04h | UTC

Covid-19 booster vaccines: What we know and who’s doing what – The BMJ

 

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

24 Aug, 2021 | 10:06h | UTC

RCT: Effect of Early Treatment with Fluvoxamine on Risk of Emergency Care and Hospitalization Among Patients with COVID-19 – Together Clinical Trials

Related:

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 

How will Delta evolve? Here’s what the theory tells us.

24 Aug, 2021 | 09:58h | UTC

How will Delta evolve? Here’s what the theory tells us – The Conversation

 

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – “Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza”.

24 Aug, 2021 | 09:51h | UTC

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – Pediatrics

Related:

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

AAP Guidance: Post-COVID-19 conditions in children and adolescents.

Cohort study: Risk factors for long covid in previously hospitalized children.

Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Deaths from COVID ‘incredibly rare’ among children.

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

 

Perspective | How should schools and daycare treat colds in the covid age? It’s complicated. – “Will every sniffle and cough be treated as potential Covid until proven otherwise?”.

24 Aug, 2021 | 09:53h | UTC

How Should Schools And Daycare Treat Colds In The Covid Age? It’s Complicated. – Romper

 

COVID vaccines protect against Delta, but their effectiveness wanes.

24 Aug, 2021 | 09:57h | UTC

COVID vaccines protect against Delta, but their effectiveness wanes – Nature

Original study: [Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.

 

European guidelines on microscopic colitis.

24 Aug, 2021 | 08:58h | UTC

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations – UEG Journal

 

RCT: SGLT2 inhibition reduces the risk of hyperkalemia in patients with diabetes and chronic kidney disease.

24 Aug, 2021 | 08:57h | UTC

Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Adult ADHD is linked to numerous physical conditions.

24 Aug, 2021 | 08:41h | UTC

Adult ADHD is linked to numerous physical conditions – Karolinska Institutet

Original study: Mapping phenotypic and aetiological associations between ADHD and physical conditions in adulthood in Sweden: a genetically informed register study – The Lancet Psychiatry

 

Commentaries on Twitter

 

Among patients receiving mRNA vaccines, clinically significant symptoms were more frequent following dose 2, following dose 1 in patients with previous SARS-CoV-2 infection, and in those who received the Moderna vaccine.

22 Aug, 2021 | 23:54h | UTC

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers – JAMA Internal Medicine

 

Commentary on Twitter

 

RCT: A single-session of pain management skills intervention was noninferior to 8 sessions of cognitive behavioral therapy in adults with chronic low back pain.

24 Aug, 2021 | 08:39h | UTC

Comparison of a Single-Session Pain Management Skills Intervention With a Single-Session Health Education Intervention and 8 Sessions of Cognitive Behavioral Therapy in Adults With Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Single two-hour session of pain management skills could offer as much benefit as longer-course of CBT – News Medical

New approach effectively relieves chronic low back pain – Stanford Medicine

 

Commentary on Twitter

 

[Preprint] Study shows symptomatic breakthrough infections are probably less transmissible than SARS-CoV-2 infections in unvaccinated individuals.

22 Aug, 2021 | 23:59h | UTC

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study – medRxiv

 

Commentary on Twitter (thread – click for more)

 

Evidence mounts that people with breakthrough infections can spread Delta easily.

22 Aug, 2021 | 23:57h | UTC

Evidence mounts that people with breakthrough infections can spread Delta easily – National Geographic

Original study: Shedding of Infectious SARS-CoV-2 Despite Vaccination when the Delta Variant is Prevalent – Wisconsin, July 2021 – medRxiv

 

Commentary on Twitter

 

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