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Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

22 Aug, 2021 | 23:51h | UTC

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study – The Lancet Respiratory Medicine

Invited Commentary: Heterologous ChAdOx1-nCoV19–BNT162b2 vaccination provides superior immunogenicity against COVID-19

Related:

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)

 

Commentary on Twitter

 

[Preprint] SARS-CoV-2 aerosol transmission in schools: theoretical effectiveness of different interventions – “Combined interventions (i.e., natural ventilation, masks, and HEPA filtration) were the most effective (≥ 30-fold decrease)”.

22 Aug, 2021 | 23:50h | UTC

SARS-CoV-2 aerosol transmission in schools: the effectiveness of different interventions – medRxiv

Related: The right way to protect our children and return to in-person learning – CNN

 

Commentaries on Twitter

 

ACOG Guideline: Osteoporosis prevention, screening, and diagnosis.

22 Aug, 2021 | 23:08h | UTC

Osteoporosis Prevention, Screening, and Diagnosis: ACOG Clinical Practice Guideline No. 1 – Obstetrics & Gynecology

 

NICE Guideline: Obstructive sleep apnea/hypopnea syndrome and obesity hypoventilation syndrome in over 16s.

22 Aug, 2021 | 23:10h | UTC

Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s – National Institute for Health and Care Excellence

 

M-A: GLP-1 receptor agonists reduce major adverse cardiovascular events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes.

22 Aug, 2021 | 22:50h | UTC

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related: Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

 

M-A: The role of SGLT2 inhibitors in heart failure.

22 Aug, 2021 | 22:46h | UTC

The Role of SGLT2 Inhibitors in Heart Failure: A Systematic Review and Meta-Analysis – Cardiology Research and Practice

Related:

ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.

Guideline: SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes – This guidance recommends a risk-based approach, advising against starting SGLT-2 inhibitors or GLP-1 receptor agonists in patients with three or fewer cardiovascular risk factors and without established CVD or CKD.

Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.

M-A: SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure.

Meta-analysis: Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with Type 2 diabetes

#ESCCongress – [Abstract Only] SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

[Abstract Only] Randomized Trial: SGLT2 Inhibitor Improves Outcomes in Patients with Heart Failure Even in the Absence of Diabetes

 

Why remote consultation with a doctor is difficult – and how it can be improved.

22 Aug, 2021 | 23:00h | UTC

Why remote consultation with a doctor is difficult – and how it can be improved – The Conversation

Original article: Planning and Evaluating Remote Consultation Services: A New Conceptual Framework Incorporating Complexity and Practical Ethics – Frontiers in Digital Health

 

Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1428664245357584390

 

The assessment of blood pressure in pregnant women: pitfalls and novel approaches.

22 Aug, 2021 | 22:12h | UTC

The assessment of blood pressure in pregnant women: pitfalls and novel approaches – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

Study: Macrolide use significantly associated with both prevalent and incident tinnitus.

22 Aug, 2021 | 22:11h | UTC

Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss – Journal of Antimicrobial Chemotherapy

Commentary: Macrolide Use and Tinnitus: A New Safety Ringtone? – NEJM Journal Watch (free for a limited period)

 

[Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.

20 Aug, 2021 | 10:03h | UTC

Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK – University of Oxford

Commentaries:

Vaccines Are Less Effective Against Delta—And Pfizer’s Protection Wanes Rapidly—But Are The Best Way To Protect Against Covid, Large Study Finds – Forbes

Expert reaction to preprint looking at the impact of the delta variant on vaccine effectiveness – Science Media Centre

Pfizer vaccine effectiveness declines faster than AstraZeneca – study – Evening Standard

 

Commentary on Twitter

 

Covid-19: How many variants are there, and what do we know about them?

20 Aug, 2021 | 10:00h | UTC

Covid-19: How many variants are there, and what do we know about them? – The BMJ

 

Commentary on Twitter

 

A grim warning from Israel: Vaccination blunts, but does not defeat Delta.

20 Aug, 2021 | 09:56h | UTC

A grim warning from Israel: Vaccination blunts, but does not defeat Delta – Science

 

Delta’s rise is fuelled by rampant spread from people who feel fine.

20 Aug, 2021 | 09:54h | UTC

Delta’s rise is fuelled by rampant spread from people who feel fine – Nature

Original study: Transmission dynamics and epidemiological characteristics of Delta variant infections in China – medRxiv

 

Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome.

20 Aug, 2021 | 09:51h | UTC

Post-Covid-19 Tachycardia Syndrome: A distinct phenotype of Post-acute Covid-19 Syndrome – The American Journal of Medicine

 

Commentary on Twitter

 

Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team.

20 Aug, 2021 | 09:49h | UTC

Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team – Canadian Journal of Cardiology

 

Prescription medications for use in pregnancy – perspective from the US Food and Drug Administration.

20 Aug, 2021 | 08:55h | UTC

Prescription medications for use in pregnancy–perspective from the US Food and Drug Administration – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

Study finds increased risk of gastrointestinal bleeding following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants.

20 Aug, 2021 | 08:45h | UTC

Gastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants – Heart (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Viewpoint: Confronting the Delta variant of SARS-CoV-2.

19 Aug, 2021 | 09:03h | UTC

Confronting the Delta Variant of SARS-CoV-2, Summer 2021 – JAMA

 

Studies: COVID vaccine protection waning against infection but not hospitalization.

19 Aug, 2021 | 09:05h | UTC

Studies: COVID vaccine protection waning against infection but not hospitalization – CIDRAP

Study 1: Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults — United States, March–July 2021 – CDC Morbidity and Mortality Weekly Report

Study 2: Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021 – CDC Morbidity and Mortality Weekly Report

Study 3: New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status — New York, May 3–July 25, 2021 – CDC Morbidity and Mortality Weekly Report

 

Commentary on Twitter (thread – click for more)

 

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

19 Aug, 2021 | 09:06h | UTC

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms – NIH News Releases

Original study: Early Convalescent Plasma for High-Risk Outpatients with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

 

NICE Guideline: Antenatal care.

19 Aug, 2021 | 08:53h | UTC

Antenatal care – National Institutes for Health and Care Excellence

 

RCT: Mediterranean diet reduces atherosclerosis progression.

19 Aug, 2021 | 08:48h | UTC

Mediterranean Diet Reduces Atherosclerosis Progression – American College of Cardiology

Original study: Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease: An Analysis of the CORDIOPREV Randomized Controlled Trial – Stroke

 

Nine in ten children with ADHD may experience symptoms into young adulthood.

19 Aug, 2021 | 08:45h | UTC

Nine in Ten Children With ADHD May Experience Symptoms Into Young Adulthood – Psychiatric News Alert

Original study: Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD – The American Journal of Psychiatry

 

As use of widely prescribed stimulants increases, experts see troubling parallels to opioid crisis.

19 Aug, 2021 | 08:46h | UTC

As use of widely prescribed stimulants increases, experts see troubling parallels to opioid crisis – STAT

 

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

18 Aug, 2021 | 09:04h | UTC

SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination – The Lancet

Related:

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)

 

Commentary on Twitter (thread – click for more)

 

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