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Family Medicine

Review: Primary care-based cardiovascular disease risk management after adverse pregnancy outcomes.

1 Feb, 2022 | 08:29h | UTC

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine (if the link is paywalled, try this one)

Commentary: Better management of long-term heart disease risk needed following complicated pregnancies – Boston Medical Center

See also: thread from the author on Twitter summarizing the article

Related:

A national cohort study in Sweden showed pregnancy complications (preeclampsia or eclampsia, gestational hypertension, gestational diabetes, preterm birth, small for gestational age, and stillbirth) are associated with increased risk of cardiovascular disease later in life.

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors (recent studies on the subject)

 

M-A: The diagnostic accuracy of syndromic management for genital ulcer disease.

1 Feb, 2022 | 08:12h | UTC

The Diagnostic Accuracy of Syndromic Management for Genital Ulcer Disease: A Systematic Review and Meta-Analysis – Frontiers in Medicine

 

Systematic Review: Self‐management interventions for people with chronic obstructive pulmonary disease.

1 Feb, 2022 | 08:21h | UTC

Self‐management interventions for people with chronic obstructive pulmonary disease – Cochrane Library

Summary: Self-management for people with chronic obstructive pulmonary disease – Cochrane Library

 

Commentary on Twitter

 

Registry study in Denmark found an increased bleeding risk with the association of systemic Fluconazole and Apixaban (OR 3.5; 95% CI, 1.4-10.6).

1 Feb, 2022 | 08:13h | UTC

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

 

Position Paper: Preventing heart failure.

30 Jan, 2022 | 14:53h | UTC

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

 

M-A: Association of antenatal diet and physical activity–based interventions with gestational weight gain and pregnancy.

1 Feb, 2022 | 08:10h | UTC

Association of Antenatal Diet and Physical Activity–Based Interventions With Gestational Weight Gain and Pregnancy Outcomes: A Systematic Review and Meta-analysis – JAMA Internal Medicine

News Release: New evidence shows the importance of healthy lifestyle programs in pregnancy – University of Monash

 

Commentary on Twitter

 

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

30 Jan, 2022 | 14:40h | UTC

Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study – European Journal of Pediatrics

Related:

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter

 

FDA halts use of antibody drugs that don’t work vs. Omicron.

30 Jan, 2022 | 14:35h | UTC

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Related: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

RCT: Vitamin D supplementation for older adults (mean age 67 years) for 5 years reduced the risk of autoimmune diseases by 22%. Absolute risk in the treatment group was 0.95% vs. 1.19% in the placebo group.

30 Jan, 2022 | 14:30h | UTC

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Commentary: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Related:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

30 Jan, 2022 | 14:37h | UTC

England lifts COVID restrictions as omicron threat recedes – Associated Press

Denmark confirms plan to lift Covid-19 restrictions on February 1st – The Local dk

Netherlands lifts toughest Covid curbs with Denmark and France set to follow – The Guardian

Denmark will lift nearly ALL Covid restrictions within days and return to ‘life as we knew it before corona’ after vaccine programme proved a ‘super-weapon’ – despite soaring cases – Daily Mail

 

Commentary on Twitter

 

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

30 Jan, 2022 | 14:34h | UTC

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents – New England Journal of Medicine

Related:

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Commentary on Twitter

 

Systematic Review: Low‐carbohydrate vs. balanced‐carbohydrate diets for reducing weight and cardiovascular risk.

30 Jan, 2022 | 14:28h | UTC

Low‐carbohydrate versus balanced‐carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

Summary: Low-carbohydrate diets or balanced-carbohydrate diets: which works better for weight loss and heart disease risks? – Cochrane Library

Commentary: Featured review: Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1487879806100414474

 

Guideline Summary: Management of the top 10 most common immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

30 Jan, 2022 | 14:11h | UTC

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Original Article: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Related:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (several resources on the subject)

 

Review: Essential tremor.

30 Jan, 2022 | 14:08h | UTC

Essential tremor – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Essential tremor (if the link is paywalled, try this one)

 

Commentary on Twitter

 

M-A: Helicobacter pylori eradication may result in modest improvement in functional dyspepsia.

30 Jan, 2022 | 14:01h | UTC

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis – Gut (link to abstract – $ for full-text)

Commentary: H. pylori eradication therapy may lead to better outcomes for functional dyspepsia – ACP Gastroenterology

 

M-A: SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure.

30 Jan, 2022 | 13:56h | UTC

SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis – European Heart Journal – Cardiovascular Pharmacotherapy

 

Commentary on Twitter

 

Risk of obstetric anal sphincter injury among women who birth vaginally after a prior cesarean section: A state-wide cohort study.

30 Jan, 2022 | 13:48h | UTC

Risk of obstetric anal sphincter injury among women who birth vaginally after a prior caesarean section: A state-wide cohort study – BJOG (link to abstract – $ for full-text)

Commentary: Vaginal birth after caesarean increases the risk of serious perineal tear by 20%, our large-scale review shows – The Conversation

 

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

30 Jan, 2022 | 13:59h | UTC

Mistakes in dietary management of IBS and how to avoid them – United European Gastroenterology

Related:

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Commentary on Twitter (thread – click for more)

 

Cohort Study: Association of preeclampsia and perinatal complications with offspring neurodevelopmental and psychiatric disorders.

30 Jan, 2022 | 13:51h | UTC

Association of Preeclampsia and Perinatal Complications With Offspring Neurodevelopmental and Psychiatric Disorders – JAMA Network Open

 

Perspective | Where do we stand with Omicron? The data, the math, the patterns, and the exit.

28 Jan, 2022 | 08:39h | UTC

Where do we stand with Omicron? – by Dr. Eric Topol

 

Commentary on Twitter

 

After Omicron, some scientists foresee ‘a period of quiet’.

28 Jan, 2022 | 08:36h | UTC

After Omicron, some scientists foresee ‘a period of quiet’ – Science

 

WHO systematic review and meta-analysis: efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children.

28 Jan, 2022 | 08:27h | UTC

Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis – Pain

 

During the COVID-19 pandemic, female, primary care, and behavioral health physicians were most likely to be early adopters of virtual health care. Physicians born between 1928 and 1945 and in surgical specialties were less likely to be early adopters.

28 Jan, 2022 | 08:20h | UTC

Association of Physician Characteristics With Early Adoption of Virtual Health Care – JAMA Network Open

 

Development and use of a calculator to measure pediatric low-value care delivered in US children’s hospitals.

28 Jan, 2022 | 08:19h | UTC

Development and Use of a Calculator to Measure Pediatric Low-Value Care Delivered in US Children’s Hospitals – JAMA Network Open

Commentary: Pediatric Services With Limited Benefits Cost Millions – MedPage Today (free registration required)

 

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

27 Jan, 2022 | 10:03h | UTC

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant – New England Journal of Medicine

Commentary: Current anti-COVID pills work well against omicron, but antibody drugs are less effective, study finds – University of Wisconsin-Madison

 

Commentary on Twitter

 

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