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Endocrinology (all articles)

Review | Primary aldosteronism: a pragmatic approach to diagnosis and management

4 Aug, 2023 | 12:06h | UTC

Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management – Mayo Clinic Proceedings

 

Brief Review | How do I diagnose and treat my patient’s amiodarone-induced thyrotoxicosis?

4 Aug, 2023 | 11:52h | UTC

How do I diagnose and treat my patient’s amiodarone-induced thyrotoxicosis? – Cleveland Clinic Journal of Medicine

 

Review | Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

1 Aug, 2023 | 14:19h | UTC

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options – Cardiovascular Research

Related:

From NAFLD to MASLD | New consensus changes fatty liver disease terminology to avoid stigmatization

Nonalcoholic fatty liver disease from a primary care perspective – Diabetes, Obesity and Metabolism

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease – Hepatology

Management of NAFLD in primary care settings – Liver International

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

Review | Vegetarian and vegan diets: benefits and drawbacks

1 Aug, 2023 | 14:11h | UTC

Vegetarian and vegan diets: benefits and drawbacks – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 

Observational Study | More data suggesting Rosuvastatin 10mg/Ezetimibe 10mg combo may be an alternative to Rosuvastatin 20mg

31 Jul, 2023 | 14:38h | UTC

Combination Lipid-Lowering Therapy in Patients Undergoing Percutaneous Coronary Intervention – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

Statins post PCI: Moderate intensity plus ezetimibe may be preferable – Cardiology News

Combination Lipid-Lowering Therapy After PCI – American College of Cardiology

Related: Open-label RCT | Moderate-intensity statin plus ezetimibe is noninferior to high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease.

 

Commentary on Twitter

 

WHO updates guidelines on fats and carbohydrates

28 Jul, 2023 | 14:25h | UTC

News Release: WHO updates guidelines on fats and carbohydrates – World Health Organization

Guidelines:

Saturated fatty acid and trans-fatty acid intake for adults and children: WHO guideline – World Health Organization

Total fat intake for the prevention of unhealthy weight gain in adults and children: WHO guideline – World Health Organization

Carbohydrate intake for adults and children: WHO guideline – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Study | New deep learning model effectively detects type 2 diabetes from chest X-rays

28 Jul, 2023 | 14:15h | UTC

Opportunistic detection of type 2 diabetes using deep learning from frontal chest radiographs – Nature Communications

 

Commentary on Twitter

 

Cohort Study | Exploring the potential impact of artificial sweeteners on type 2 diabetes risk

28 Jul, 2023 | 14:07h | UTC

Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort – Diabetes Care

 

RCT | Liraglutide aids weight management in patients with suboptimal weight loss post metabolic surgery

28 Jul, 2023 | 14:05h | UTC

Safety and Efficacy of Liraglutide, 3.0 mg, Once Daily vs Placebo in Patients With Poor Weight Loss Following Metabolic Surgery: The BARI-OPTIMISE Randomized Clinical Trial – JAMA Surgery

See also: Visual Abstract

 

RCT – 2ry Analysis | Elevated intracranial bleeding risk with low-dose aspirin in older adults

27 Jul, 2023 | 13:09h | UTC

Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People: Secondary Analysis of a Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

News Release: Low dose aspirin won’t help some older adults trying to avoid a stroke: study – Monash University

Commentary: Daily aspirin doesn’t prevent strokes in older, healthy people after all – The Conversation

Original Study: Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Guideline: USPSTF Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

#347 USPSTF Update: Aspirin for Primary Prevention of CVD – The Curbsiders

 

Scientific Statement | Addressing childhood obesity to reduce adult CV risk through lifestyle

27 Jul, 2023 | 13:03h | UTC

Lifestyle interventions to change trajectories of obesity-related cardiovascular risk from childhood onset to manifestation in adulthood: a joint scientific statement of the task force for childhood health of the European Association of Preventive Cardiology and the European Childhood Obesity Group – European Journal of Preventive Cardiology

News Release: How to stop obese children having heart disease in adulthood – European Society of Cardiology

 

Podcast | Obesity medicine, GLP1 agonists, weight loss management tools and tips

27 Jul, 2023 | 12:55h | UTC

#405 Obesity Medicine, GLP1 agonists, Weight Loss Management Tools and Tips – The Curbsiders

 

RCT | Pitavastatin effective in the primary prevention of cardiovascular disease in HIV-infected individuals

26 Jul, 2023 | 13:35h | UTC

Pitavastatin to Prevent Cardiovascular Disease in HIV Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Pitavastatin lowers risk of cardiovascular events in people living with HIV – Aidsmap

Statins reduce cardiovascular risk in people living with HIV, new global study finds – STAT

Pitavastatin Cuts MACE in HIV-Infected Patients: REPRIEVE – TCTMD

 

Commentary on Twitter

 

Cohort Study | More data suggests SGLT-2 inhibitors could reduce gout flares

26 Jul, 2023 | 13:24h | UTC

Comparative Effectiveness of Sodium–Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations: A General Population Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

SGLT-2 inhibitors reduced gout flares in patients with diabetes, gout – ACP Internist

SGLT2i Use Linked to Reduced Risk for Flare in Adults With Gout, T2D – HealthDay

SGLT2 inhibitors linked with fewer gout flares in diabetes – MDedge

 

M-A | Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals

26 Jul, 2023 | 13:15h | UTC

Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: M-A: Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals – HCP Live

 

RCT | Vitamin D supplementation shows no cognitive benefit in mild cognitive impairment intervention

25 Jul, 2023 | 14:00h | UTC

Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Network Open

Commentary: Exercise and Cognitive Training Slow Thinking Declines. Vitamin D? Not So Much – HealthDay

Related:

RCT | No statistically significant impact of vitamin D on major cardiovascular events

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Cohort Study | BMI of 25.0–29.9 not linked with higher mortality in 21st century U.S. adults

25 Jul, 2023 | 13:58h | UTC

Body mass index and all-cause mortality in a 21st century U.S. population: A National Health Interview Survey analysis – PLOS One

News Release: No increase in mortality for most overweight people, study finds – PLOS

Commentary: Expert reaction to study looking at BMI and all-cause mortality – Science Media Centre

 

Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus

21 Jul, 2023 | 13:50h | UTC

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

 

USPSTF Statement | Evidence lacking for lipid disorders screening in asymptomatic children and adolescents

20 Jul, 2023 | 11:13h | UTC

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Screening for Lipid Disorders in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Editorial: Still “on the Fence” About Universal Childhood Lipid Screening: The USPSTF Reaffirms an I Statement – JAMA

Patient Page: Screening for Lipid Disorders in Children and Adolescents – JAMA

Commentary: USPSTF: Screening Kids for Lipid Disorders Still Needs More Data – TCTMD

 

M-A | Hepatic, extra-hepatic outcomes and causes of mortality in NAFLD

20 Jul, 2023 | 10:59h | UTC

Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis – Journal of Clinical and Experimental Hepatology

 

Review | Painful diabetic peripheral neuropathy

20 Jul, 2023 | 10:53h | UTC

Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management – Diabetes, Metabolic Syndrome and Obesity

 

IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake

18 Jul, 2023 | 13:58h | UTC

News Release: Aspartame hazard and risk assessment results released – World Health Organization

Commentaries:

Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre

Does artificial sweetener aspartame really cause cancer? What the WHO listing means for your diet soft drink habit – The Conversation

Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post

 

Review | Cushing Syndrome

13 Jul, 2023 | 13:08h | UTC

Cushing Syndrome: A Review – JAMA (free for a limited period)

Audio clinical review: Diagnosis and Treatment of Cushing Syndrome – JAMA

 

RCT | Metformin boosts effectiveness of lifestyle interventions for diabetes prevention in individuals with impaired glucose regulation

13 Jul, 2023 | 13:07h | UTC

Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related Study: Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin – New England Journal of Medicine (link to abstract – $ for full-text)

 

Single Arm Trial | Low-carbohydrate diet improves glycemic control in type 1 diabetes

13 Jul, 2023 | 13:04h | UTC

Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial – PLOS One

Related:

Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (link to abstract – $ for full-text)

Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences

RCT | A calorie-unrestricted low-carbohydrate, high-fat diet resulted in short-term weight loss and better glycemic control.

Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials – Nutrients

Consensus Statement: Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management.

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

Lower carbohydrate diets for adults with type 2 diabetes – British Journal of Nutrition

Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

Diabetes Canada Position Statement on Low-Carbohydrate Diets for Adults With Diabetes: A Rapid Review – Canadian Journal of Diabetes

Low Carbohydrate Diets for Diabetes: A Review of the Clinical Effectiveness and Guidelines – Canadian Agency for Drugs and Technologies in Health

Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide – British Journal of General Practice

 

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