Endocrinology (all articles)
SR: Metformin has modest efficacy for children with obesity
24 Feb, 2021 | 02:08h | UTCEfficacy and Safety of Metformin for Obesity: A Systematic Review – Pediatrics (link to abstract – $ for full-text)
Commentary: Metformin Underwhelms in Pediatric Obesity – Physician’s Weekly
Meta-analysis: Effect of food variety on intake of a meal
21 Feb, 2021 | 21:33h | UTC
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
Dieting may slow metabolism – but it doesn’t ruin it
18 Feb, 2021 | 02:44h | UTCDieting may slow metabolism – but it doesn’t ruin it – The Conversation
M-A: Intake of dietary fats and fatty acids and the incidence of type 2 diabetes
16 Feb, 2021 | 01:59h | UTC
RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults
11 Feb, 2021 | 02:09h | UTCOnce-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch
Commentary on Twitter
This double-blind study randomly assigned adults with obesity without diabetes to 68 weeks of once-weekly subcutaneous semaglutide or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.
— NEJM (@NEJM) February 10, 2021
Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity
11 Feb, 2021 | 01:56h | UTC
Commentary on Twitter
36-week randomized cross-over trial:
💥Low-fat plant-based diet reduced body weight, fat mass, and visceral fat, increased insulin sensitivity, and improved blood lipids, compared with a Mediterranean diet.https://t.co/ROJX9WYcix
— Danielle Belardo, MD (@DBelardoMD) February 6, 2021
Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar
11 Feb, 2021 | 01:54h | UTC
Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions
10 Feb, 2021 | 01:25h | UTC
Commentary on Twitter
Cardiovascular health during menopause, pregnancy, and other gynaecologic conditions: European multidisciplinary consensus is out !https://t.co/fm6EBEbhVO.#cardiotwitter, @ESC_Journals, @escardio, #gynecology pic.twitter.com/WIekM50b07
— EHJ Editor-in-Chief (@ehj_ed) January 26, 2021
SR: Long‐term effects of weight‐reducing diets in people with hypertension
10 Feb, 2021 | 01:23h | UTCLong‐term effects of weight‐reducing diets in people with hypertension – Cochrane Library
Cohort study: Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes
10 Feb, 2021 | 01:16h | UTCCharacteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries on Twitter
New #research online: Characteristics and outcomes of #pregnant women with type 1 or type 2 #diabetes: a 5-year national population-based cohort study https://t.co/qCOHToYDEa pic.twitter.com/ENAmhkhKvZ
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) January 29, 2021
Important study from Prof Helen Murphy and colleagues in UK highlighting adverse outcomes in pregnancy with #Type2 and #type1diabetes. Glucose control and #obesity were main determinants. Big challenges ahead with increasing young-onset #type2
#maternalhealth
@FIGOadvocacy https://t.co/X99hsN4KcK— Dr Ronald Ma (@DrRonaldMa1) January 31, 2021
Cohort study: Low risk of progression to diabetes among older adults with “prediabetes”
9 Feb, 2021 | 01:09h | UTCRisk of Progression to Diabetes Among Older Adults With Prediabetes – JAMA Internal Medicine (free for a limited period)
Commentaries: “Prediabetes” Diagnosis Less Useful in Older Patients – Johns Hopkins Bloomberg School of Public Health AND Prediabetes—A Risk Factor Twice Removed – JAMA Internal Medicine (free for a limited period) AND How many pre-diabetics go on to develop diabetes? – MedicalResearch.com
Author Interview: Risk of Progression to Diabetes Among Older Adults With Prediabetes
Related: The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science
M-A: Effects of whole grain intake, compared with refined grain, on appetite and energy intake
9 Feb, 2021 | 00:50h | UTC
Commentary on Twitter
Effects of Whole Grain Intake, Compared with Refined Grain, on Appetite and Energy Intake: A Systematic Review and Meta-Analysis
"Whole grains modestly but significantly reduced
hunger…"https://t.co/wS1Vql4KHi@nutritionorg @jnutritionorg pic.twitter.com/5UWa28wkPW— Lukas Schwingshackl (@LSchwingshackl) February 8, 2021
SR/MA: Up to a third of patients may discontinue thyroid hormone replacement and remain euthyroid
7 Feb, 2021 | 21:02h | UTCClinical Outcomes After Discontinuation of Thyroid Hormone Replacement: A Systematic Review and Meta-Analysis – Thyroid (link to abstract – $ for full-text)
Commentary: A Third Discontinuing Levothyroxine Have Normal Thyroid Levels – Medscape (free registration required)
Commentaries on Twitter
Hard to believe that simply treating hypothyroidism may fit into “Things We Do For No Reason.”
But >1/3 of people on thyroid replacement stay euthyroid after stopping meds.
See article for results, predictors of euthyroidism, & de-escalation strategies.https://t.co/i1f04FnbPk pic.twitter.com/fGLAbjNo5B
— David A. Cohen (@DavidACohen_MD) January 21, 2021
(thread – click for more)
#endocation #endotwitter #endotips #endorules
Hypothyroidism🧠: Third of Patients Treated for
Hypothyroidism May Not Require Thyroid Hormones❗️https://t.co/iAZcwFB5Ul✅Hypothyroidism: 5% of population, age dependent
✅NHANES: 6.4% reported use of levothyroxine (LT4)1/
— Fady Hannah-Shmouni, MD FRCPC (@DrShmouni) January 14, 2021
Cohort study: Increased consumption of refined grains linked to higher risk of mortality and major cardiovascular disease events
5 Feb, 2021 | 01:30h | UTCCommentaries: Refined carbs like white bread, pasta, and pastries could increase risk of early death, a study found – Insider AND High intake of refined grains linked to higher risk of heart disease and death – The BMJ
Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes
4 Feb, 2021 | 01:00h | UTCOriginal Study: Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)
AAP urges continuing obesity management
2 Feb, 2021 | 01:03h | UTCAAP urges continuing obesity management – Contemporary Pediatrics
Original Guideline: Obesity Management and Treatment During COVID-19 – American Academy of Pediatrics
Management of diabetes and hyperglycemia in the hospital
29 Jan, 2021 | 01:34h | UTCManagement of diabetes and hyperglycaemia in the hospital – The Lancet Diabetes & Endocrinology (free for a limited period)
Commentary on Twitter
https://twitter.com/TheLancetEndo/status/1354754451161100288
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
27 Jan, 2021 | 01:08h | UTCVitamin D, Calcium, Other Vitamins, and Supplements Do Not Prevent CVD – TCTMD
Original study 1: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Original study 2: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
10-year follow up of a randomized trial shows metabolic surgery is more effective than conventional medical therapy for the control of type 2 diabetes
26 Jan, 2021 | 00:44h | UTCMetabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Randomized crossover study shows lower ad libitum energy intake with a plant-based, low-fat diet compared to an animal-based, ketogenic diet
25 Jan, 2021 | 01:25h | UTCCommentary: NIH study compares low-fat, plant-based diet to low-carb, animal-based diet – NIH News Releases
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
[Abstract Only] Meta-analysis: Ablation of aldosterone producing adenoma is associated with a reduced operative duration, decreased intraoperative blood loss, and faster postoperative recovery compared to laparoscopic adrenalectomy
21 Jan, 2021 | 00:50h | UTCAblation versus laparoscopic adrenalectomy for the treatment of aldosterone‑producing adenoma: a meta-analysis – Abdominal Radiology (link to abstract – $ for full-text)
Perspective – Sugar-sweetened beverage taxes: Lessons to date and the future of taxation
20 Jan, 2021 | 01:28h | UTCSugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine
Related: Meta-Analysis: Impact of Sugar‐sweetened Beverage Taxes on Purchases and Dietary Intake (free study and resources on the subject)