Editor's Choice | Page 9 of 113 | Links Medicus Content Curation & Alerts in Medicine

Multinational Study | No correlation between Covid-19 and onset of type 1 diabetes in children

8 Aug, 2023 | 13:32h | UTC

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens – New England Journal of Medicine

Perspective | Will unpredictable side effects dim the promise of new Alzheimer’s drugs?

8 Aug, 2023 | 13:30h | UTC

Will unpredictable side effects dim the promise of new Alzheimer’s drugs? – Science (a few articles per month are free)

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns

NICE Updated Guideline | Venous thromboembolic diseases

7 Aug, 2023 | 15:05h | UTC

Venous thromboembolic diseases: diagnosis, management and thrombophilia testing – National Institute for Health and Care Excellence

Review | Management of worsening heart failure with reduced ejection fraction

7 Aug, 2023 | 15:03h | UTC

Management of Worsening Heart Failure With Reduced Ejection Fraction: JACC Focus Seminar 3/3 – Journal of the American College of Cardiology

Commentary on Twitter

How do you manage patients with worsening #HFrEF? This review by @SJGreene_md, @JavedButler1 and team provides the latest evidence-based guidance for the medical management of this high-risk population. https://t.co/REAqsrHDjI #JACC #CardioTwitter @ShelleyZieroth @DCRINews pic.twitter.com/rZYD25vCoG

— JACC Journals (@JACCJournals) August 5, 2023

Cohort Study | High-sensitivity troponin’s role in assessing MI and CV death risk in stable CAD patients

7 Aug, 2023 | 15:01h | UTC

High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

High-Sensitivity Troponin Assays May Stratify Risk in Chronic CAD – TCTMD

High-Sensitivity Cardiac Troponin for Risk Assessment in Chronic CAD – Journal of the American College of Cardiology

Commentary on Twitter

In patients with chronic CAD, an elevated #troponin identifies those more likely to have MI or CV death. Routine troponin testing in this setting could inform patient selection for additional treatment. https://t.co/T4HfidPwOA #JACC #cvCAD #CardioTwitter #cvPrev #cvMI pic.twitter.com/2IOU8jsFPj

— JACC Journals (@JACCJournals) August 1, 2023

Survey | The manifold costs of being a non-native English speaker in science

7 Aug, 2023 | 15:00h | UTC

The manifold costs of being a non-native English speaker in science – PLOS Biology

Commentary from the author: Non-native English speaking scientists work much harder just to keep up, global research reveals – The Conversation

News Releases:

The cost of being a non-native English speaker in science – PLOS

Science language barrier could cost countless careers – University of Queensland

Commentary on Twitter

Some potential solutions to reducing disadvantages for non-native English speakers in publishing & conferences

By @tatsuya_amano & colleagues from their seminal @PLOSBiology paperhttps://t.co/luBndai3FQ @PLOS pic.twitter.com/68x6rZBMW4

— Madhu Pai, MD, PhD (@paimadhu) August 5, 2023

Perspective | The paradoxical decline of geriatric medicine as a profession

7 Aug, 2023 | 14:57h | UTC

The Paradoxical Decline of Geriatric Medicine as a Profession – JAMA (free for a limited period)

Commentary on Twitter

Viewpoint: author Jerry Gurwitz discusses the attrition of geriatric medicine as a profession, attributing it in part to societal attitudes about aging and compounded by the negative effects of lower compensation and lack of career prestige. https://t.co/5uydZzMrqS pic.twitter.com/RFY5grczQ4

— JAMA (@JAMA_current) August 4, 2023

USPSTF | Reaffirming the importance of folic acid to all women planning to or who could become pregnant to prevent neural tube defects

4 Aug, 2023 | 12:15h | UTC

Folic Acid Supplementation to Prevent Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA

Evidence Report: Folic Acid Supplementation to Prevent Neural Tube Defects: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Folic Acid to Prevent Neural Tube Defects – JAMA

Commentary on Twitter

2023 Recommendation Statement from the USPSTF: all persons planning to or who could become pregnant should take a daily supplement containing 0.4 to 0.8 mg (400 to 800 μg) of folic acid (A recommendation). https://t.co/gdavbWyZZ7 pic.twitter.com/2PAjb0OCBO

— JAMA (@JAMA_current) August 1, 2023

RCT | Mammography screening with AI reduces workload by 44.3% without loss in detection efficacy

4 Aug, 2023 | 12:13h | UTC

Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study – The Lancet Oncology (link to abstract – $ for full-text)

News Release: First randomized trial finds AI-supported mammography screening is safe and almost halves radiologist workload – Lancet

Commentaries:

Large Mammography Study Shows Significant Benefits with AI-Aided Screening – Diagnostic Imaging

Expert reaction to interim safety analysis of randomised trial on AI-supported mammography screening – Science Media Centre

RCT | 52-week antidepressant adjunctive therapy did not lead to a statistically significant benefit over 8-week therapy in bipolar I depression

4 Aug, 2023 | 12:11h | UTC

Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Modern antidepressants may reduce risk of relapse for patients with bipolar depression – University of British Columbia

Commentary on Twitter

Among patients with bipolar I disorder who had remission of depression, there was no significant difference in the incidence of relapse of any mood episode between 8 weeks and 52 weeks of antidepressant treatment. Full results of the BEAM-BD trial: https://t.co/rCkCqIfMb6

— NEJM (@NEJM) August 2, 2023

Study | Removal of thymus in adults linked to increased death, cancer incidence

4 Aug, 2023 | 12:09h | UTC

Health Consequences of Thymus Removal in Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Doctors have long considered the thymus expendable. But could removing it be fatal? – Science

The thymus withers away after puberty. But it may be important for adults – Science News

Thymus gland critical for adult health, study finds – News Medical

Commentary on Twitter

In a study by Kooshesh et al., mortality, the risk of cancer, and levels of proinflammatory cytokines were higher among adults whose thymus had been removed than among control patients. Read the full study results: https://t.co/poaAiELsKG

— NEJM (@NEJM) August 2, 2023

Review | ‘Pragmatic’ trials changing research: Balancing traditional controls with real-world care needs

4 Aug, 2023 | 12:08h | UTC

Clinical Trials Overview: From Explanatory to Pragmatic Clinical Trials – Mayo Clinic Proceedings

Editorial: Introduction to Thematic Reviews on Forward Thinking on Clinical Trials in Clinical Practice – Mayo Clinic Proceedings

Review | Primary aldosteronism: a pragmatic approach to diagnosis and management

4 Aug, 2023 | 12:06h | UTC

Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management – Mayo Clinic Proceedings

ACP Guidance | Asymptomatic CRC screening advised from age 50 with fecal occult blood test every 2 years or colonoscopy every 10 years

3 Aug, 2023 | 13:48h | UTC

Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians – Annals of Internal Medicine

News Release: ACP issues updated guidance for colorectal cancer screening of asymptomatic adults – American College of Physicians

Commentary: Start screening for colorectal cancer at age 50 years, ACP suggests – ACP Internist

Summary for Patients: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults – Annals of Internal Medicine

RCT | Recombinant human prourokinase demonstrates noninferiority to alteplase in acute ischemic stroke treatment

3 Aug, 2023 | 13:46h | UTC

Efficacy and Safety of Recombinant Human Prourokinase in the Treatment of Acute Ischemic Stroke Within 4.5 Hours of Stroke Onset: A Phase 3 Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

RCT – 2ry analysis | Omega-3 supplementation linked to increased AF risk in post-MI patients

3 Aug, 2023 | 13:45h | UTC

Omega-3 fatty acid supplements and risk of atrial fibrillation and ‘micro-atrial fibrillation’: A secondary analysis from the OMEMI trial – Clinical Nutrition

M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.

More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.

RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction

#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

Meta-Analysis of Randomized Trials: Little Benefit from Omega-3 Intake to Reduce Cardiovascular Disease Risk

Commentary from the author on Twitter (thread – click for more)

RCT data consistently show that Omega-3 suppl increase AF risk https://t.co/LQVHfPNtKL

In this substudy of the #OMEMI trial we add novel data from thumb-ECG screening and serum EPA/DHA, supporting a causal relation between omega-3 (EPA) and AF!https://t.co/B9VoDNQpZi

🧵 1/4 pic.twitter.com/GFYGfVaNMq

— Peder L. Myhre MD, PhD (@pmyhre) July 28, 2023

Global prevalence, years lived with disability, and trends in anemia burden by severity and cause, 1990–2021

3 Aug, 2023 | 13:43h | UTC

Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990–2021: findings from the Global Burden of Disease Study 2021 – The Lancet Haematology

News Release: New study reveals global anemia cases remain persistently high among women and children. Anemia rates decline for men – Institute for Health Metrics and Evaluation

Commentary on Twitter

NEW #GBD study by @IHME_UW on the #anaemia burden by severity and cause, 1990–2021🧵https://t.co/NbiEDSkbGI

Despite a decrease in prevalence, the number of people with anaemia increased globally

In every region females had a higher #anemia YLDs than males pic.twitter.com/oFx4vHRhs1

— The Lancet Haematology (@TheLancetHaem) August 1, 2023

WHO | Seven out of 10 people protected by at least one tobacco control measure

2 Aug, 2023 | 14:14h | UTC

News Release: Seven out of 10 people protected by at least one tobacco control measure – World Health Organization

See also: MPOWER measures

Report: WHO report on the global tobacco epidemic, 2023: protect people from tobacco smoke – World Health Organization

Commentaries:

While Anti-Smoking Policies Cover 70% of Global Population, Taxation is Under-Utilised – Health Policy Watch

Expert reaction to WHO report on the global tobacco epidemic 2023 – Science Media Centre

Commentary on Twitter

The MPOWER measures include📌

𝗠-onitoring tobacco use
𝗣-rotecting people from tobacco smoke
𝗢-ffering support to quit smoking
𝗪-arning about the dangers of tobacco
𝗘-nforcing tobacco advertising, promotion & sponsorship bans
𝗥-aising taxes on Tobacco

Learn more.… pic.twitter.com/ImfGsL8in1

— World Health Organization (WHO) (@WHO) July 31, 2023