Editor's Choice
Cluster RCT | Tighter vs. less tight glycemic targets for women with gestational diabetes mellitus for reducing maternal and perinatal morbidity.
13 Sep, 2022 | 13:21h | UTC
Dementia: evidence, experience and resources.
13 Sep, 2022 | 13:20h | UTCDementia: evidence, experience and resources – Evidently Cochrane
RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.
13 Sep, 2022 | 13:19h | UTC
Commentary on Twitter
In the VIP-ACS trial, among patients hospitalised with an ACS, double dose influenza vaccination before discharge does not reduce cardiovascular and pulmonary outcomes compared with standard dose vaccination 👉https://t.co/L9e7MXWfWV#EHJ #ESCCongress @ehj_ed @rladeiraslopes pic.twitter.com/95o50krrwm
— European Society of Cardiology Journals (@ESC_Journals) August 31, 2022
Review / Perspective | Which patients with aortic stenosis should be referred to surgery rather than transcatheter aortic valve implantation?
13 Sep, 2022 | 13:18h | UTC
Commentary on Twitter
https://twitter.com/ESC_Journals/status/1526080012729864198
M-A | Blood type linked to the risk of stroke before age 60.
13 Sep, 2022 | 13:17h | UTCContribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke – Neurology (link to abstract – $ for full-text)
News Releases:
Is your blood type linked to your risk of stroke before age 60? – American Academy of Neurology
Blood Type Linked To Stroke Risk Before 60 – University of Maryland
RCT | Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19.
13 Sep, 2022 | 13:16h | UTC
Commentaries on Twitter
Interesting results in the #PANAMO trial of vilobelimab, an anti-C5a antibody, in critically ill ICU patients w/ COVID19.
People on MV (n=386) randomized to vilobelimab vs placebo. Mortality was (maybe) reduced in a subgroup w/ more severe illness…🤔https://t.co/bO5XiRptag
1/ pic.twitter.com/EUNda67T9j— Nick Mark MD (@nickmmark) September 11, 2022
NEW Research—In addition to SOC, vilobelimab improves survival of invasive mechanically ventilated patients w/ #COVID19 and leads to a significant decrease in mortality
Read the PANAMO study from Prof Alexander Vlaar & colleagues here https://t.co/k5UuqQtqyE pic.twitter.com/Xmrb76ZpzW
— The Lancet Respiratory Medicine (@LancetRespirMed) September 8, 2022
RCT | Dipeptidyl peptidase-1 inhibition does not improve outcomes in patients hospitalized with COVID-19.
13 Sep, 2022 | 13:15h | UTC
Commentary on Twitter
NEW Research—Brensocatib treatment did not improve clinical status at day 29 in patients hospitalised with #COVID19
Being presented at #ERSCongress, ALERT 3 session, Sept 5 from 13:15 BST
From @profjdchalmers, @keirholly, @meretelong & colleagueshttps://t.co/Vlqhfs6qtj pic.twitter.com/5CY0LS4Bvy
— The Lancet Respiratory Medicine (@LancetRespirMed) September 5, 2022
Practical Recommendations | How to deal with sleep problems during heat waves.
11 Sep, 2022 | 23:00h | UTCCommentary: How to sleep in a heat wave, according to experts – CNN
RCT | In patients with severe burns, supplemental glutamine did not improve outcomes.
11 Sep, 2022 | 22:59h | UTCA Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
RE-ENERGIZE Study: In this trial involving critically ill patients with burn injuries, enteral glutamine supplementation did not reduce the time to discharge alive from the hospital. @DarenHeyland #europeanburnsassociation #eba #burns https://t.co/f69MDVmsNv pic.twitter.com/fMWr675aCJ
— NEJM (@NEJM) September 9, 2022
RCT | In youths with new-onset type 1 diabetes, intensive glucose control for 24 months with a closed-loop system did not help to preserve pancreatic function.
11 Sep, 2022 | 22:57h | UTCClosed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Preservation of C-Peptide Secretion Examined in Youth With T1D – HealthDay
Commentary on Twitter (video summary)
In patients with newly diagnosed type 1 diabetes, it is uncertain whether intensive glucose control can prevent the decline in endogenous insulin secretion. New research findings are summarized in a short video. https://t.co/gJeYus4G5z pic.twitter.com/igclSnyanu
— NEJM (@NEJM) September 10, 2022
Two large clinical trials showed Vitamin D supplements do not reduce the risk of Covid-19.
11 Sep, 2022 | 22:56h | UTCEditorial: Can vitamin D protect against covid-19? – The BMJ
News Release: No link between vitamin D supplements and reduced risk of covid-19 – BMJ Newsroom
Cohort study showed a possible link between artificial sweeteners and heart disease.
11 Sep, 2022 | 22:55h | UTCNews Release: Possible link between artificial sweeteners and heart disease – BMJ Newsroom
Original Study: Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort – The BMJ
Monkeypox: disease epidemiology, host immunity and clinical interventions.
11 Sep, 2022 | 22:54h | UTC
Commentary on Twitter
Monkeypox: disease epidemiology, host immunity and clinical interventions https://t.co/dmu06NZoPt pic.twitter.com/vZqbxp7Wzn
— Nature Rev Immunol (@NatRevImmunol) September 8, 2022
Extracorporeal membrane oxygenation during respiratory pandemics: past, present, and future.
11 Sep, 2022 | 22:53h | UTC
RCT | Rezvilutamide vs. Bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer.
11 Sep, 2022 | 22:52h | UTCCommentaries:
Treatment options for metastatic hormone-sensitive prostate cancer – The Lancet Oncology
Rezvilutamide benefits shown in metastatic hormone-sensitive prostate cancer – medwire News
Commentary on Twitter
In a preplanned interim analysis of the phase III CHART trial in pts with high-volume mHSPC, rezvilutamide +ADT improve PFS (HR 0.44, 95% CI 0.33–0·.8; P<0.0001) & OS (HR 0.58, 95% CI 0.44–0.77]; P=0.0001) compared with bicalutamide + ADT: https://t.co/42IVnDUxfH #PCSM #uroonc
— NatureRevClinOncol (@NatRevClinOncol) September 7, 2022
Cluster RCT | Umbilical cord milking may improve health in non-vigorous term and near-term infants.
8 Sep, 2022 | 14:47h | UTCNews Release: Umbilical cord milking may improve health in non-vigorous term and near-term infants – NIH News Releases
Original Study: Umbilical cord milking in non-vigorous infants: A cluster-randomized crossover trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
Does milking the umbilical cord benefit infants non-vigorous at birth?
A new RCT by @NeoAnup published in @AJOG_thegray evaluates this https://t.co/M5RRAzdEHz#neoEBM #neoTwitter #EBNEOAlerts pic.twitter.com/mZnSKjcGNt
— Evidence-Based Neo (@EBNEO) August 20, 2022
Study suggests many stable patients with ST-Elevation Myocardial Infarction may not require routine admission to a cardiac intensive care unit following PCI reperfusion.
8 Sep, 2022 | 14:45h | UTC
Early versus delayed non–vitamin k antagonist oral anticoagulant therapy after acute ischemic stroke in atrial fibrillation: a registry-based randomized controlled noninferiority study.
8 Sep, 2022 | 14:46h | UTCEarly Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study – Circulation (free for a limited period)
Commentary on Twitter
Congrats to my good friend/colleague @BoNorrving for the TIMING study! Starting NOAC after stroke d/t AF <4 d is safe (no ICH) and = or better than 5-10 d. Registry-based, pragmatic, investigator led, PROBE design. High value = science first approach.
https://t.co/35qiZ5Ivoa— Dr. Lee Schwamm (@Braindoc_MGH) September 7, 2022
Cohort Study | Long-term cardiac pathology in individuals with mild initial COVID-19 illness.
8 Sep, 2022 | 14:44h | UTCLong-term cardiac pathology in individuals with mild initial COVID-19 illness – Nature Medicine
Review | COVID-19 in children.
8 Sep, 2022 | 14:43h | UTCCOVID-19 in Children – Pediatric Clinics of North America
The Lancet Series | Acute Respiratory Distress Syndrome 2022.
7 Sep, 2022 | 12:37h | UTCHomepage: Acute Respiratory Distress Syndrome 2022 – The Lancet
Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes
Opportunities for improved clinical trial designs in acute respiratory distress syndrome
Addressing the inequity of acute respiratory distress syndrome
Stroke–heart syndrome: recent advances and challenges.
7 Sep, 2022 | 12:35h | UTCStroke–Heart Syndrome: Recent Advances and Challenges – Journal of the American Heart Association
Commentary on Twitter
Proud to share our updated review about the stroke-heart syndrome. Read more about recent advances on how brain ischemia can trigger cardiac events. https://t.co/ywJs2JbZht Many thanks to @SposatoL, @JohannesBacks and @Dr_No_Charite for your contribution! #brainheart #strokeheart pic.twitter.com/3IV9LU7fJN
— Jan Scheitz 🧠⚡️❤️ (@Jan_FriSch) September 3, 2022
Under a Creative Commons Attribution‐Non Commercial‐No Derivs License
Opinion | Tranexamic acid for safer surgery: the time is now.
7 Sep, 2022 | 12:37h | UTCTranexamic acid for safer surgery: the time is now – British Journal of Surgery
Related:
Update on applications and limitations of perioperative tranexamic acid.
Patent ductus arteriosus: a contemporary perspective for the pediatric and adult cardiac care provider.
7 Sep, 2022 | 12:34h | UTC
Review | Diagnosis and treatment of myelodysplastic syndromes.
7 Sep, 2022 | 12:33h | UTCDiagnosis and Treatment of Myelodysplastic Syndromes: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis and Management of Myelodysplastic Syndromes – JAMA