Editor's Choice | Page 47 of 113 | Links Medicus Content Curation & Alerts in Medicine

In a phase 3 trial, participants with early Alzheimer’s disease who received the monoclonal antibody lecanemab had less decline on measures of cognitive function at 18 months than those who received placebo. https://t.co/NjEloWVk1V pic.twitter.com/n33yjV9117

— NEJM (@NEJM) November 30, 2022

Cohort Study | Buprenorphine may be a safer option than Methadone for opioid use disorder in pregnancy.

2 Dec, 2022 | 14:42h | UTC

Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Buprenorphine, Not Methadone, May Be Safer Treatment for Opioid-Use Disorder During Pregnancy – Rutgers University

RCT | Effects of internet-delivered cognitive behavioral therapy on use of child sexual abuse material.

2 Dec, 2022 | 14:38h | UTC

Effects of internet-delivered cognitive behavioral therapy on use of child sexual abuse material: A randomized placebo-controlled trial on the Darknet – Internet Interventions

News Release: Reduced use of child sexual abuse material after online CBT – Karolinska Institutet

Commentary on Twitter (thread – click for more)

https://twitter.com/NiklasLangstrom/status/1598206403294171138

Case-control study | Effectiveness of COVID-19 vaccines against infection and mortality in children in Argentina.

2 Dec, 2022 | 14:36h | UTC

Effectiveness of mRNA-1273, BNT162b2, and BBIBP-CorV vaccines against infection and mortality in children in Argentina, during predominance of delta and omicron covid-19 variants: test negative, case-control study – The BMJ

RCT | Single-dose Acoziborole is effective and safe for patients with sleeping sickness.

2 Dec, 2022 | 14:35h | UTC

Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial – The Lancet Infectious Diseases

News Release: New single-dose treatment for sleeping sickness could help eliminate transmission of the disease by 2030 – The Lancet

Commentary: Single dose of acoziborole 95% effective in treating sleeping sickness – CIDRAP

Cross-sectional study | Overweight women may be at increased risk of long Covid.

2 Dec, 2022 | 14:33h | UTC

Post-COVID-19 syndrome risk factors and further use of health services in East England – PLOS Global Public Health

Commentaries:

Overweight women may be at highest risk of long COVID – new research – The Conversation

Women having a higher BMI more likely to experience long Covid – University of East Anglia / News Medical

M-A | Risk of hypovolemia associated with sodium–glucose cotransporter-2 inhibitors treatment.

2 Dec, 2022 | 14:31h | UTC

Risk of hypovolemia associated with sodium–glucose cotransporter-2 inhibitors treatment: A meta-analysis of randomized controlled trials – Frontiers in Cardiovascular Medicine

WHO Pocket book of primary health care for children and adolescents.

1 Dec, 2022 | 14:09h | UTC

Pocket book of primary health care for children and adolescents: guidelines for health promotion, disease prevention and management from the newborn period to adolescence (2022) – World Health Organization

M-A | Sodium restriction in patients with heart failure.

1 Dec, 2022 | 14:08h | UTC

Sodium Restriction in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials – Circulation: Heart Failure (link to abstract – $ for full-text)

Commentary: Sodium Restriction No Help, No Harm in HF, Meta-analysis Confirms – TCTMD

Commentary on Twitter

In a meta-analysis of 17 RCT incl. the SODIUM-HF RCT, dietary sodium restriction did not reduce the risk of death or hospitalization in patients w/ HF @justinezekowitz @CVC_UAlberta #AHAJournals https://t.co/7xEr1bJgkz pic.twitter.com/4Gfrlx264i

— Circ: Heart Failure (@CircHF) November 17, 2022

Phase 2b RCT | Cannabidiol oil failed to relieve symptoms in advanced cancer.

1 Dec, 2022 | 14:04h | UTC

Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD) – Journal of Clinical Oncology

Commentary: Cannabis oil failed to improve pain or quality of life in palliative care cancer patients, study shows – The Guardian

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Systematic Review: Cannabis-based products for chronic pain.

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

RCT | Combining loop with thiazide diuretics for decompensated heart failure.

1 Dec, 2022 | 14:02h | UTC

Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial – European Heart Journal

Commentary on Twitter

Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial https://t.co/wGfKpo03H6 @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/VfnQnp2AKa

— European Society of Cardiology Journals (@ESC_Journals) November 30, 2022

M-A | Placebo response and media attention in randomized clinical trials assessing cannabis-based therapies for pain.

1 Dec, 2022 | 14:06h | UTC

Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain: A Systematic Review and Meta-analysis – JAMA Network Open

News Release: Positive media coverage of cannabis studies regardless of therapeutic effect – Karolinska Institutet

Commentaries:

Cannabis is no better than a placebo for treating pain – new research – The Conversation

Media Coverage, Placebo Response Linked to Pain Relief Seen in Cannabinoid Trials – Psychiatric News Alert

Commentary on Twitter

Cannabinoid clinical trials for pain generate relatively high media attention despite low effect sizes, which may help shape placebo responses in subsequent trials. https://t.co/sINTpeGeMO

— JAMA Network Open (@JAMANetworkOpen) November 28, 2022

M-A | Efficacy and safety of COVID-19 inactivated vaccine.

1 Dec, 2022 | 14:00h | UTC

Efficacy and safety of COVID-19 inactivated vaccine: A meta-analysis – Frontiers in Medicine

Study shows smartwatch ECGs can detect left ventricular dysfunction.

1 Dec, 2022 | 13:59h | UTC

Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction – Nature Medicine (link to abstract – $ for full-text)

News Release: AI transforms smartwatch ECG signals into a diagnostic tool for heart failure – Mayo Clinic

Commentary: AI Accurately Detects LV Dysfunction Using Single-Lead Apple Watch ECG – TCTMD

Commentary on Twitter

In this proof-of-concept prospective study, single-lead electrocardiograms obtained by #SmartWatches were able to identify individuals with left ventricular dysfunction, potentially serving as an early-warning system for heart failure @drpaulfriedman https://t.co/uXXUWPqHqP

— Nature Medicine (@NatureMedicine) November 15, 2022

Collection of Cochrane evidence on diagnosing tuberculosis.

1 Dec, 2022 | 13:56h | UTC

Collection of Cochrane evidence on diagnosing tuberculosis – Cochrane Library

RCT | Medical masks vs. N95 respirators for preventing COVID-19 among health care workers.

30 Nov, 2022 | 13:52h | UTC

Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers: A Randomized Trial – Annals of Internal Medicine

News Release: In some settings, medical masks may offer similar effectiveness to N95 respirators for preventing COVID-19 infection among health care workers – American College of Physicians

Editorial: Comparative Effectiveness of Mask Type in Preventing SARS-CoV-2 in Health Care Workers: Uncertainty Persists – Annals of Internal Medicine

Commentary on Twitter

A randomized trial of medical masks vs N95s in health care workers to prevent Covid https://t.co/CSJkFLE15z
—It's woefully underpowered but ruled out a doubling of hazard for use of medical masks
—In 3 of the 4 countries there was less risk with N95s (p=NS) pic.twitter.com/B7iBvT1J9B

— Eric Topol (@EricTopol) November 28, 2022

WHO report urges more effective prevention of injuries and violence causing 1 in 12 deaths worldwide.

30 Nov, 2022 | 13:55h | UTC

News Release: WHO urges more effective prevention of injuries and violence causing 1 in 12 deaths worldwide – World Health Organization

Report: Preventing injuries and violence: an overview – World Health Organization

Commentary on Twitter

12,000.
🚗 12,000 people.
🔪 12,000 people die from injuries & violence.
🌊 12,000 people die from injuries & violence around the world.
☠️ 12,000 people die from injuries & violence around the world every day.

These deaths can be prevented https://t.co/TRbCFKUcdu pic.twitter.com/DtIyLBat3y

— World Health Organization (WHO) (@WHO) November 29, 2022

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