Editor's Choice
M-A | Utility of differential time to positivity in diagnosing central line associated bloodstream infections
26 Apr, 2023 | 14:24h | UTC
Commentary on Twitter
https://twitter.com/CIDJournal/status/1648807186443673600
ADHD Medication Misuse | 25% of students in some US schools report nonmedical use for stimulant effect
26 Apr, 2023 | 14:21h | UTCNews Release: In some US schools, 1 in 4 students report misusing prescription stimulants – University of Michigan
Commentary on Twitter
Prescription stimulant misuse varies from 0% to >25% across US secondary schools. Schools with highest rates of stimulant therapy for #ADHD had 36% increased odds of misuse, offering targets for prevention and risk reduction strategies. https://t.co/4XHGpooBjz
— JAMA Network Open (@JAMANetworkOpen) April 18, 2023
Opinion | Precision palliative care as a pragmatic solution for a care delivery problem
26 Apr, 2023 | 14:19h | UTC
Commentary from the author on Twitter (thread – click for more)
In the @JCO_ASCO‼️‼️, @ravi_b_parikh & I make the case for 🎯"Precision Palliative Care" 🎯as a pragmatic solution for a care delivery problem
A 🧵
Article https://t.co/1mYcaVIov4 pic.twitter.com/5Kj87rcuZK— Ramy Sedhom, MD, FASCO (@ramsedhom) April 22, 2023
AGA Practical Guidance | Diagnosis and management of extraesophageal gastroesophageal reflux disease
25 Apr, 2023 | 14:50h | UTCCommentary: Guidance offered on management of extraesophageal GERD – ACP Gastroenterology
Commentary on Twitter (thread – click for more)
https://twitter.com/joanwchen/status/1648804839600668675
ASCO Guideline Update | Venous thromboembolism prophylaxis and treatment in patients with cancer
25 Apr, 2023 | 14:49h | UTC
RCT | Effectiveness of an over-the-counter self-fitting hearing aid compared with an audiologist-fitted hearing aid
25 Apr, 2023 | 14:47h | UTCAuthor Interview: Effectiveness of Self-fitting vs Audiologist-Fitted Hearing Aids – JAMA
Commentaries:
Self-Fitting, Over-the-Counter Hearing Aids Beneficial – HealthDay
How Do Over-the-Counter Hearing Aids Compare with Those Fitted by Audiologists? – NEJM Journal Watch (free for a limited period)
Commentary on Twitter
Findings suggest that a self-fitting OTC hearing aid may be an effective intervention option for individuals with mild to moderate #hearingloss and produce self-perceived and clinical outcomes similar to those of an audiologist-fitted #hearingaid. https://t.co/Zbc8URj2uA
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 13, 2023
RCT | Cerebral oximetry monitoring fails to reduce death or severe brain injury in extremely preterm infants
25 Apr, 2023 | 14:45h | UTCCerebral Oximetry Monitoring in Extremely Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In extremely preterm infants, the use of cerebral oximetry monitoring to guide treatment for the first 72 hours after birth did not reduce the risk of death or severe brain injury at 36 weeks’ postmenstrual age. Full study: https://t.co/JX7Ra3OpjM pic.twitter.com/VACbUUAq3i
— NEJM (@NEJM) April 19, 2023
Cohort Study | Impact of work schedules of senior resident physicians on patient and resident physician safety
25 Apr, 2023 | 14:43h | UTCNews Release: National Study of Resident Physicians Suggests Need for Federal Work Hour Guideline Changes – Brigham and Women’s Hospital
Commentaries:
Resident Doctors’ Long Work Shifts Could Bring Peril to Patients – HealthDay
SR | Cranberries can prevent recurrent urinary tract infections in selected patients
25 Apr, 2023 | 14:41h | UTCCranberries for preventing urinary tract infections – Cochrane Library
Summary: Cranberries for preventing urinary tract infections – Cochrane Library
Commentaries:
Cranberry juice can prevent recurrent UTIs, but only for some people – The Conversation
Review confirms that cranberry products help prevent urinary tract infections – News Medical
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
25 Apr, 2023 | 14:42h | UTCSummary: 2023 GOLD Guidelines for Chronic Obstructive Pulmonary Disease – NEJM Journal Watch (free for a limited period)
Original Guidance: 2023 GOLD REPORT: global strategy for prevention, diagnosis and management of COPD: 2023 Report – Global Initiative for Chronic Obstructive Lung Disease
M-A | Surgical versus non-surgical treatment for sciatica
25 Apr, 2023 | 14:39h | UTCEditorial: Early surgery for sciatica – The BMJ
News Release: Surgery for sciatica reduces leg pain and disability, but benefits are short-lived – University of Oxford
Commentary on Twitter
Very low to low certainty evidence suggests that discectomy was superior to non-surgical treatment or epidural steroid injections in reducing leg pain and disability in people with sciatica with a surgical indication, but the benefits reduced over timehttps://t.co/kHL2HBNscF
— The BMJ (@bmj_latest) April 19, 2023
USPSTF Statement | There is insufficient evidence to guide skin cancer screening recommendations
24 Apr, 2023 | 14:07h | UTCScreening for Skin Cancer: US Preventive Services Task Force Recommendation Statement – JAMA
Evidence Report: Skin Cancer Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Editorials:
Patient Page: Screening and Prevention of Skin Cancer – JAMA
Author Interview: USPSTF Recommendation: Screening for Skin Cancer – JAMA
Commentary on Twitter
2023 Recommendation Statement from the USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of visual skin examination by a clinician to screen for #skincancer in adolescents and adults (I statement). https://t.co/WB6VN2r1Nv
— JAMA (@JAMA_current) April 18, 2023
WHO releases first-ever Standard on universal access to rapid TB diagnostics
24 Apr, 2023 | 14:04h | UTCNews Release: WHO releases first-ever Standard on universal access to rapid TB diagnostics – World Health Organization
WHO Standard: Universal access to rapid tuberculosis diagnostics – World Health Organization
RCT | Oral fluvoxamine plus inhaled budesonide reduced hospitalizations in high-risk patients with early-onset COVID-19
24 Apr, 2023 | 13:51h | UTC
Commentary on Twitter
Treatment w/ oral fluvoxamine + inhaled budesonide among high-risk outpatients w/ early #COVID19 reduced incidence of severe disease requiring advanced care. The combined effect seems to offer benefits over individual use of each drug: https://t.co/wM2da5a5MD pic.twitter.com/Sl1qFzTOjD
— Annals of Int Med (@AnnalsofIM) April 19, 2023
RCT | Bariatric–metabolic surgery is more effective than lifestyle intervention plus best medical care in non-alcoholic steatohepatitis
24 Apr, 2023 | 14:03h | UTCNews Release: Surgery most effective treatment of metabolic liver disease – King’s College London
Commentary on Twitter
New @TheLancet – Verrastro et al – Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trialhttps://t.co/pCWahvbReQ#NASH #NAFLD #fattyliver #livertwitter pic.twitter.com/xNMsAskJF9
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) April 21, 2023
RCT | Higher dose corticosteroids increase mortality in hypoxic COVID-19 patients on simple oxygen
24 Apr, 2023 | 13:55h | UTCEditorial: Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia? – The Lancet
Commentary: Higher-dose corticosteroids tied to 60% more deaths in low-oxygen COVID patients – CIDRAP
Commentary on Twitter (thread – click for more)
Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support.
A new study evaluated the use of a higher dose of corticosteroids in this patient group. https://t.co/uJGSYSBQAO
— The Lancet (@TheLancet) April 13, 2023
RCT | No difference in atrial fibrillation recurrence with early vs. delayed AF ablation at 12 months
24 Apr, 2023 | 13:49h | UTCImpact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences – European Heart Journal (link to abstract – $ for full-text. Free PDF may be available here)
Commentary on Twitter
Early versus delayed ablation strategy in atrial fibrillation: read the impact on arrhythmia free survival on #EHJ!#EHRA2023 #EHJ #cardiotwitter #ablation #AF @ESC_Journals @escardio https://t.co/RW9RPry5Vi pic.twitter.com/2iHW49T3Wp
— EHJ Editor-in-Chief (@ehj_ed) April 18, 2023
Evidence Analysis | Blood pressure targets – how low can you get?
24 Apr, 2023 | 13:47h | UTCBlood pressure targets – how low can you get? – Evidently Cochrane
Original Article: SR | Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.
Commentary on Twitter
Blood pressure targets – how low can you get? https://t.co/ERLm6Mihl8 In this @CochraneUK blog, GP @rtwalton123 looks at the latest guidance & @CochraneLibrary evidence on what #BloodPressure targets to aim for, balancing the benefits of treatment against risk of side effects. pic.twitter.com/8EQH0JLzzc
— The Cochrane Library (@CochraneLibrary) April 19, 2023
2023 ACC expert consensus on management of heart failure with preserved ejection fraction
21 Apr, 2023 | 13:10h | UTCCommentaries:
New Expert Consensus Papers Aim to Boost Management, Outcomes in HFpEF – TCTMD
RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy
21 Apr, 2023 | 13:08h | UTCPiperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)
Commentary on Twitter
Study findings support the use of piperacillin-tazobactam as perioperative antimicrobial prophylaxis for open pancreatoduodenectomy. https://t.co/M9qAVrePRH pic.twitter.com/xq01qPTHQO
— JAMA (@JAMA_current) April 20, 2023
Study estimates poor diet causes 70% of diabetes cases globally
21 Apr, 2023 | 13:06h | UTCIncident type 2 diabetes attributable to suboptimal diet in 184 countries – Nature Medicine
News Release: Study links poor diet to 14 million cases of type 2 diabetes globally – Tufts University
Commentary on Twitter
An analysis in @NatureMedicine estimates that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations. https://t.co/MYoLRt3rhO pic.twitter.com/Pv7I6Mhvxu
— Nature Portfolio (@NaturePortfolio) April 19, 2023
ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity
19 Apr, 2023 | 13:27h | UTCRelated:
Exertional heat stroke: pathophysiology and risk factors – BMJ Medicine
Classic and exertional heatstroke – Nature Reviews Disease Primers
Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine
Joint statement for assessing and managing high blood pressure in children and adolescents
19 Apr, 2023 | 13:26h | UTCChapter 1: How to correctly measure blood pressure in children and adolescents – Frontiers in Pediatrics
Chapter 2: How to manage high blood pressure in children and adolescents – Frontiers in Pediatrics
Related:
AHA Scientific Statement | Pediatric primary hypertension: An underrecognized condition
AHA Scientific Statement: Ambulatory blood pressure monitoring in children and adolescents.
M-A | Glucocorticoids may increase mortality for hospitalized Covid-19 patients not receiving oxygen
19 Apr, 2023 | 13:24h | UTCMeta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen – NEJM Evidence
Commentary on Twitter (thread – click for more)
4/
💡 IMPLICATIONS#Glucocorticoids are a two-edged sword in COVID-19 treatment 🗡️
👍 Life-saving for patients receiving #oxygen☠️ Harmful for patients not on oxygen
— San Raffaele Anesthesia and Intensive Care (@SRAnesthesiaICU) April 18, 2023
RCT | Prophylactic tranexamic acid in cesarean delivery did not significantly reduce maternal death or transfusion risk
19 Apr, 2023 | 13:22h | UTCTranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Tranexamic acid does not appear to prevent maternal hemorrhage after cesarean delivery – National Institutes of Health
Commentary on Twitter
In a placebo-controlled trial involving patients undergoing cesarean delivery, prophylactic use of tranexamic acid did not lead to a significantly lower risk of a composite outcome of maternal death or blood transfusion. https://t.co/iB3axZiVqw pic.twitter.com/RDFUsspIr0
— NEJM (@NEJM) April 12, 2023