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RCT: Final analysis of efficacy and safety of single-dose J&J vaccine.

10 Feb, 2022 | 10:03h | UTC

Final Analysis of Efficacy and Safety of Single-Dose Ad26.COV2.S – New England Journal of Medicine

 

Commentary on Twitter

 

Vaccine effectiveness of heterologous CoronaVac plus Pfizer in Brazil.

10 Feb, 2022 | 10:01h | UTC

Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil – Nature Medicine

 

Commentary on Twitter

 

RCT: Subcutaneous Tirzepatide added to titrated Insulin Glargine improves glycemic control in patients with Type 2 Diabetes.

10 Feb, 2022 | 10:00h | UTC

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Tirzepatide for Patients With Type 2 Diabetes – JAMA

Commentary: SURPASS-5 Data: Tirzepatide Plus Insulin Glargine Improve Glycemic Control in T2D – AJMC

Related:

RCT: In patients with Type 2 Diabetes, Tirzepatide is associated with reduced weight, improved glycemic control, and lower risk of hypoglycemia compared to insulin glargine.

RCT: Once-weekly tirzepatide vs. once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes.

RCT: Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2.

RCT: Tirzepatide yielded greater glycated hemoglobin and body weight reductions compared to Semaglutide 1 mg.

 

Opinion: Development of clinical practice guidelines ‘is a mess’.

9 Feb, 2022 | 10:16h | UTC

Development of clinical practice guidelines ‘is a mess’ – STAT

 

IDSA Updated Covid-19 Guideline now supports the use of convalescent plasma in ambulatory patients with mild to moderate COVID-19 at high risk for progression to severe disease.

9 Feb, 2022 | 10:15h | UTC

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

Related: [Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.

 

Commentary on Twitter

 

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

9 Feb, 2022 | 10:18h | UTC

European Society of clinical microbiology and infectious diseases (ESCMID) guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli (endorsed by ESICM –European Society of intensive care Medicine) – Clinical Microbiology and Infection

Related: IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

 

WHO: Two years into COVID pandemic, most countries still face significant health service disruptions.

9 Feb, 2022 | 10:13h | UTC

Two Years into COVID Pandemic, Most Countries Still Face Significant Health Service Disruptions – Health Policy Watch

Original Report: Third round of the global pulse survey on continuity of essential health services during the COVID-19 pandemic – World Health Organization

 

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

9 Feb, 2022 | 10:12h | UTC

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study – The Lancet Child & Adolescent Health

See also: Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study – The Lancet Child & Adolescent Health

Editorial: Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond – The Lancet Child & Adolescent Health

Commentary: Long COVID and kids: more research is urgently needed – Nature

Related:

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter (thread – click for more)

 

Though rare, Moderna Covid vaccine recipients have higher risk of heart inflammation than Pfizer.

9 Feb, 2022 | 10:06h | UTC

Though rare, Moderna Covid vaccine recipients have higher risk of heart inflammation than Pfizer – CNBC

Related:

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

 

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

9 Feb, 2022 | 10:08h | UTC

Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy: a multi-database, self-controlled case series study -medRxiv

Related:

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Commentary on Twitter

 

Study suggests routine cardiac screening is not needed before return to play in junior competitive athletes with mild or asymptomatic SARS-CoV-2.

9 Feb, 2022 | 10:01h | UTC

SARS-CoV-2 infection and return to play in junior competitive athletes: is systematic cardiac screening needed? – British Journal of Sports Medicine

 

Perspective | Tracking COVID-19 infections: time for change.

9 Feb, 2022 | 10:03h | UTC

Tracking COVID-19 infections: time for change – Nature

 

Systematic Review: Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations.

9 Feb, 2022 | 10:02h | UTC

Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review – Clinical Microbiology and Infection

 

ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting.

8 Feb, 2022 | 10:18h | UTC

ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the healthcare setting – Clinical Microbiology and Infection

 

Randomized crossover study shows regular use of Paracetamol increases systolic blood pressure by approximately 5 mm Hg when compared with placebo in hypertensive individuals.

8 Feb, 2022 | 10:11h | UTC

Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial – Circulation (link to abstract – $ for full-text)

Commentaries:

Regular paracetamol use linked to higher blood pressure, study finds – University of Edinburg

Expert reaction to study looking at regular, long-term paracetamol use and blood pressure, in people with high blood pressures – Science Media Centre

Blood pressure warning over long-term paracetamol use – BBC

 

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

8 Feb, 2022 | 10:15h | UTC

News Release: COVID-19 infections increase risk of heart conditions up to a year later, study finds – Washington University in St. Louis

Original Study: Long-term cardiovascular outcomes of COVID-19 – Nature Medicine

 

Rapid control of hospital-based SARS-CoV-2 Omicron clusters through daily testing and universal use of N95 respirators.

8 Feb, 2022 | 10:09h | UTC

Rapid control of hospital-based SARS-CoV-2 Omicron clusters through daily testing and universal use of N95 respirators – Clinical Infectious Diseases

 

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.

8 Feb, 2022 | 10:08h | UTC

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly – Proceedings of the National Academy of Sciences

Commentary: Wastewater monitoring for public health – University of California

Related:

CDC unveils its latest weapon in Covid-19 detection: wastewater.

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

 

Fresh research says Omicron lasts much longer on surfaces than other variants – but disinfecting still works.

8 Feb, 2022 | 10:05h | UTC

Fresh research says Omicron lasts much longer on surfaces than other variants – but disinfecting still works – The Conversation

 

Sudden rise of more transmissible form of Omicron catches scientists by surprise.

8 Feb, 2022 | 10:06h | UTC

Sudden rise of more transmissible form of Omicron catches scientists by surprise – Science

Related:

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

 

Perspective | Three, four or more: what’s the magic number for booster shots?

8 Feb, 2022 | 10:03h | UTC

Three, four or more: what’s the magic number for booster shots? – Nature

 

Where did Omicron come from? Three key theories.

8 Feb, 2022 | 10:04h | UTC

Where did Omicron come from? Three key theories – Nature

 

Practice guidelines for office and out-of-office blood pressure measurement.

8 Feb, 2022 | 10:02h | UTC

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement – Journal of Hypertension

 

Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation.

7 Feb, 2022 | 08:56h | UTC

Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation – The American Journal of Emergency Medicine

 

Editorial: “Excess deaths” is the best metric for tracking the pandemic.

7 Feb, 2022 | 08:54h | UTC

“Excess deaths” is the best metric for tracking the pandemic – The BMJ

Related:

The pandemic’s true death toll: millions more than official counts.

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentaries on Twitter

 

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