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Critical Care & Emergencies (all articles)

Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension

12 Nov, 2020 | 09:22h | UTC

Divergent: age, frailty, and atypical presentations of COVID-19 in hospitalized patients – The Journals of Gerontology

 

Commentary on Twitter

 

Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality

12 Nov, 2020 | 09:24h | UTC

Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study – Journal of Neurology, Neurosurgery & Psychiatry

Commentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business

 

[Abstract Only] Study: An automated predictive model can identify hospitalized adults outside the ICU at risk for clinical deterioration for whom interventions by rapid-response teams could be implemented

13 Nov, 2020 | 09:16h | UTC

Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration – New England Journal of Medicine (link to abstract – $ for full-text)

 

Why do COVID death rates seem to be falling? Correct use of corticosteroids, hard-won experience, younger patients, and reduced strain on hospitals are all possibilities

12 Nov, 2020 | 09:16h | UTC

Why do COVID death rates seem to be falling? – Nature

 

[Preprint] Validation of home oxygen saturation as a marker of clinical deterioration in patients with suspected COVID-19: Even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk.

12 Nov, 2020 | 09:18h | UTC

Validation of home oxygen saturations as a marker of clinical deterioration in patients with suspected COVID-19 – medRxiv

 

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Prone position in ARDS patients: why, when, how and for whom

12 Nov, 2020 | 09:11h | UTC

Prone position in ARDS patients: why, when, how and for whom – Intensive Care Medicine

 

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Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score

11 Nov, 2020 | 09:18h | UTC

Troponin and Other Biomarker Levels and Outcomes Among Patients Hospitalized with COVID‐19: Derivation and Validation of the HA2T2 COVID‐19 Mortality Risk Score – Journal of the American Heart Association

 

Commentary on Twitter

 

[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome

11 Nov, 2020 | 09:08h | UTC

Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial – Annals of Emergency Medicine

 

Commentary on Twitter

 

Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths

11 Nov, 2020 | 09:06h | UTC

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)

 

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Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19

10 Nov, 2020 | 09:39h | UTC

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science

Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases

 

Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present

10 Nov, 2020 | 09:37h | UTC

Characterization of Myocardial Injury in Patients With COVID-19 – Journal of the American College of Cardiology

Commentary: Study identifies cardiac structural damage experienced by COVID-19 patients – Mount Sinai Health System / News Medical

 

Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients

10 Nov, 2020 | 09:33h | UTC

Multidrug-Resistant Candida auris Infections in Critically Ill Coronavirus Disease Patients, India, April–July 2020 – Emerging Infectious Diseases

Commentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic

 

In patients hospitalized with COVID-19, right ventricular dilation or dysfunction was independently associated with a >2-fold increase in risk for mortality

10 Nov, 2020 | 09:36h | UTC

Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 – Journal of the American College of Cardiology

Commentaries: Utility of RV Remodeling Over Risk Stratification in COVID-19 – American College of Cardiology AND Damage to heart’s right ventricle predicts a greater chance of death from COVID-19 – Weill Cornell Medical College

 

Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial

10 Nov, 2020 | 09:35h | UTC

Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial – University of Oxford

Commentary: Aspirin to be tested as potential COVID-19 drug in UK study – Reuters

 

Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”

10 Nov, 2020 | 09:30h | UTC

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome – Cochrane Library

 

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

10 Nov, 2020 | 09:26h | UTC

Current and evolving standards of care for patients with ARDS – Annals of Intensive Care

 

Commentary on Twitter

 

Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed

10 Nov, 2020 | 09:24h | UTC

Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings

 

JACC Focus Seminar: Advanced management of intermediate- and high-risk pulmonary embolism. Patients who deteriorate despite anticoagulation and those with high-risk PE should be considered for advanced therapies for pulmonary reperfusion, including systemic fibrinolysis, surgical embolectomy, and catheter-based therapies

9 Nov, 2020 | 01:20h | UTC

Advanced Management of Intermediate- and High-Risk Pulmonary Embolism: JACC Focus Seminar – Journal of the American College of Cardiology (free for a limited period)

Podcast: Advanced Management of Intermediate- and High-Risk Pulmonary Embolism: JACC Focus Seminar

 

Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack

9 Nov, 2020 | 01:16h | UTC

Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial – JAMA Neurology

Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

 

Randomized trial: Similar outcomes with goal-directed hemodynamic therapy vs. restrictive normovolemic therapy in major open abdominal surgery

6 Nov, 2020 | 09:34h | UTC

Goal-directed hemodynamic therapy versus restrictive normovolemic therapy in major open abdominal surgery: A randomized controlled trial – Surgery

 

Commentary on Twitter

 

Postmortem lungs of COVID-19 patients show massive damage

5 Nov, 2020 | 09:06h | UTC

Postmortem lungs of COVID-19 patients show massive damage- CIDRAP

Original article: Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology – EBioMedicine

 

NICE Guideline: Human and animal bites. Assessment, indications for antibiotic prophylaxis in uninfected bites, and choice of antibiotic are reviewed

5 Nov, 2020 | 09:02h | UTC

Human and animal bites: antimicrobial prescribing – National Institute for Health and Care Excellence

 

Review: Clinical Management of Hyperkalemia. Classification and monitoring, when to reinitiate RAASi therapy, use oral K+-binding agents, and more

5 Nov, 2020 | 08:58h | UTC

Clinical Management of Hyperkalemia – Mayo Clinic Proceedings

 

Review: Diagnosis and treatment of lower extremity venous thromboembolism. Role of pretest probability and D-Dimer on diagnosis + treatment issues such as postthrombotic syndrome and the role of new anticoagulants

5 Nov, 2020 | 09:00h | UTC

Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review – JAMA (free for a limited period)

Summary: Diagnosis and Treatment of Lower Extremity Venous Thromboembolism – American College of Cardiology

 

Review of clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort

5 Nov, 2020 | 08:46h | UTC

Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort – Intensive Care Medicine

 

Commentary on Twitter

 

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