Critical Care & Emergencies (all articles)
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS. Dosage, timing of initiation, mode of administration, duration of therapy, infection surveillance, tapering, and more
5 Nov, 2020 | 08:45h | UTC
Commentary on Twitter
Glucocorticoids in #ARDS… focus not only on molecule! Key elements to achieve optimal response to therapy:
➡️ dosage (initial, overtime, adjustments)
➡️ timing of initiation
➡️ mode of administration
➡️ duration of therapy
➡️ tapering
➡️ co-interventionshttps://t.co/4b9vtNXsb7 pic.twitter.com/X6UZyMSI1r— Intensive Care Medicine (@yourICM) November 4, 2020
New CDC Report found that pregnant women with Covid-19 are more likely to have severe illness
4 Nov, 2020 | 09:47h | UTCCommentary: Pregnant women with Covid-19 face higher risk of severe illness and death, study says – CNN
Review: Management of common postoperative complications
4 Nov, 2020 | 09:26h | UTCManagement of Common Postoperative Complications – Mayo Clinic Proceedings
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort
4 Nov, 2020 | 09:19h | UTC
Commentary on Twitter
Protecting lung (vs excessive stress/strain) & diaphragm (vs atrophy/injury due to low/excessive efforts) bedside:
➡️ inspiratory/expiratory MV settings
➡️ monitoring & managing effort or drive
➡️ managing dyssynchrony
➡️ sedation
➡️ adjuvant strategieshttps://t.co/pdvKndwHYY pic.twitter.com/irvrX9WxTj— Intensive Care Medicine (@yourICM) November 2, 2020
Updated clinical guide for the critical care management of adults with COVID-19
3 Nov, 2020 | 03:18h | UTC
Perspective: A series of disappointing results of immune-based therapies for COVID-19
3 Nov, 2020 | 03:13h | UTCA Series of Disappointing Results of Immune-Based Therapies for COVID-19 – HIV and ID Observations
Updated guidelines to reduce venous thromboembolism in trauma patients
3 Nov, 2020 | 03:08h | UTC
Review: A standardized and comprehensive approach to the management of cardiogenic shock
3 Nov, 2020 | 03:04h | UTCCommentary: New Review Urges Rethink of Cardiogenic Shock Care – TCTMD
The value of urinary sodium assessment in acute heart failure
3 Nov, 2020 | 03:02h | UTC
[Abstract Only] Cohort study: Sodium–Glucose Cotransporter-2 Inhibitors and the risk for diabetic ketoacidosis
3 Nov, 2020 | 03:01h | UTCCommentarios: Can You Spot Euglycemic DKA From SGLT-2 Inhibitors? – Journal Feed AND Sodium glucose cotransporter-2 inhibitor use associated with increased risk of diabetic ketoacidosis – 2 Minute Medicine
Regeneron: Independent committee recommends holding trial enrollment in hospitalized patients with high oxygen requirements
2 Nov, 2020 | 02:31h | UTC
Commentary on Twitter
More potential evidence against antibody drugs late in course of #COVID19: Regeneron says independent cmte has recommended not enrolling pts on high oxygen into trial "based on a potential safety signal and an unfavorable risk/benefit profile at this time" https://t.co/moHtuhV9cP
— Meg Tirrell (@megtirrell) October 30, 2020
Trends in COVID-19 risk-adjusted mortality rates
2 Nov, 2020 | 02:24h | UTCTrends in COVID-19 Risk-Adjusted Mortality Rates – Journal of Hospital Medicine
Commentary on Twitter
Trends in COVID-19 Risk-Adjusted Mortality Rates | Journal of Hospital Medicine: “Data from one health system suggest that mortality from COVID-19 is decreasing even after accounting for patient characteristics.” https://t.co/AtQ6lPnzhQ
— Dr. Ron Daniels BEM (@SepsisUK) October 25, 2020
Case study: Urinary magnesium in the evaluation of hypomagnesemia
2 Nov, 2020 | 02:19h | UTCUrinary Magnesium in the Evaluation of Hypomagnesemia – JAMA (free for a limited period)
The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug
30 Oct, 2020 | 01:14h | UTCThe ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug – Science
Commentaries on Twitter
Remdesivir, despite failing in Solidarity trial, received FDA approval without input from outside advisory group. EU cut pricing deal with Gilead without knowing Solidarity data. @kakape and I explain in "The ‘very, very bad look’ of remdesivir" https://t.co/yTKq2A1WQT pic.twitter.com/NhBLum09VG
— Jon Cohen (@sciencecohen) October 28, 2020
Uncovering a scandal about Gilead and Remdesivir
Deep reporting by @sciencecohen and @kakape @ScienceMagazine
The company knew the #SOLIDARITY trial data well before it its preprint. And so did the FDA before giving a full approval, w/o external review https://t.co/4REMEwTvc5— Eric Topol (@EricTopol) October 28, 2020
Videos in clinical medicine: Percutaneous Tracheostomy
30 Oct, 2020 | 01:05h | UTCPercutaneous Tracheostomy – New England Journal of Medicine
AHA Scientific Statement: Prevention of complications in the cardiac intensive care unit
30 Oct, 2020 | 01:06h | UTCCommentary: New strategies suggested for critical heart care in the ICU – American Heart Association
Randomized phase 2 trial: SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19
29 Oct, 2020 | 09:16h | UTCAudio Interview: A New Monoclonal Antibody for Covid-19 – New England Journal of Medicine
Commentaries on Twitter
BLAZE-1🔥 – outpatient trial of LY-Cov555, mAb recently dropped from ACTIV-3 inpatient trial
Only 1 of the 3 mAb dosages (middle one 🤷♂️) ⬇️ VL by d11
mAb assoc with modest ⬇️ in healthcare visits (1.6% vs 6.3% for placebo)
😑 Far from a game changerhttps://t.co/zZMGlodaaF pic.twitter.com/ofs1UgN1ZA
— Ilan Schwartz is on🦋 (@GermHunterMD) October 28, 2020
Phase 2 Lilly #SARSCoV2 monoclonal antibody outpatient trial just published @NEJM
The lack of a dose response for viral load reduction +modest effects on symptoms do not make this look like a potent intervention https://t.co/oyRG8fUNHf pic.twitter.com/uobuCIznmD— Eric Topol (@EricTopol) October 28, 2020
Ten tips to optimize weaning and extubation success in the critically ill
29 Oct, 2020 | 08:50h | UTCTen tips to optimize weaning and extubation success in the critically ill – Intensive Care Medicine
Commentary on Twitter
Wean/extubate critically ills
1⃣optimize (⬇️) sedation
2⃣diaphragm-protective MV
3⃣daily screen for SBT
4⃣best SBT?
5⃣weaning strategy
6⃣what if SBT fails
7⃣muscle load/efficiency ratio
8⃣weaning/extubation failure
9⃣post-extubation support
🔟 tracheostomyhttps://t.co/TaYdzMvisK pic.twitter.com/q9qQOVKioZ— Intensive Care Medicine (@yourICM) October 27, 2020
Lilly antibody drug fails in a Covid-19 study; others go on
28 Oct, 2020 | 09:10h | UTCLilly antibody drug fails in a Covid-19 study; others go on – CNBC
Observational Study: Ticagrelor, compared with clopidogrel, is not associated with better outcomes for patients with ACS treated with PCI
28 Oct, 2020 | 08:54h | UTCAssociation of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention – JAMA (free for a limited period)
Editorial: Net Adverse Clinical Events With Antiplatelet Therapy in Acute Coronary Syndromes – JAMA (free for a limited period)
Author Interview: Ticagrelor or Clopidogrel for Antiplatelet Therapy After Percutaneous Intervention for Acute Coronary Syndrome? – JAMA
Commentary on Twitter
In @JAMA_current, our article comparing ticagrelor and clopidogrel in patients with an acute coronary syndrome undergoing PCI. A remarkable international collaboration. Bottom line: more expensive med not better. https://t.co/SDAyI7Q1MV pic.twitter.com/RFmmy4qvrW
— Harlan Krumholz (@hmkyale) October 27, 2020
[Abstract Only] Meta-analysis: Complication of vasopressor infusion through peripheral venous catheter
28 Oct, 2020 | 08:49h | UTCComplication of vasopressor infusion through peripheral venous catheter: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Evidence is mounting that vasopressors administered through peripheral IVs are associated w/ minimal complications, especially if safety guidelines are implemented. Check out this recent meta-analysis: https://t.co/2Z0xzGDfRG
Does your ED have a policy on vasopressor PIV admin?
— ASHP Emergency Medicine (@ASHP_EMPharm) October 25, 2020
JACC Journal series gives in-depth look at COVID-19’s impact on the heart
27 Oct, 2020 | 09:49h | UTCNews release: Journal series gives in-depth look at COVID-19’s impact on the heart – American College of Cardiology
JACC Focus Seminar 1: Coronavirus and Cardiometabolic Syndrome
JACC Focus Seminar 2: Coronavirus Historical Perspective, Disease Mechanisms, and Clinical Outcomes
JACC Focus Seminar 3: Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia
Observational study on the effectiveness of deep sedation for patients with intractable electrical storm refractory to antiarrhythmic drugs
27 Oct, 2020 | 09:34h | UTC
Commentary on Twitter
Effectiveness of deep sedation for patients with intractable electrical storm refractory to anti-arrhythmic drugs https://t.co/sY7R3rtdvF #AHAJournals @MartinsRaphae15 @EloiMarijon pic.twitter.com/7SD3epIUUi
— Circulation (@CircAHA) October 23, 2020
Randomized trial suggests rapid intermittent bolus of hypertonic saline is the best approach for the treatment of symptomatic hyponatremia
27 Oct, 2020 | 09:36h | UTC
For managing symptomatic #hyponatremia, both rapid intermittent bolus (RIB) and slow continuous infusion of hypertonic saline are safe and effective, but RIB achieves a target serum sodium sooner and needs lesser therapeutic re-lowering of serum sodium https://t.co/J4y4BbA855
— JAMA Internal Medicine (@JAMAInternalMed) October 26, 2020
Guideline: Airway management in adult trauma patients
27 Oct, 2020 | 09:30h | UTC
Commentary on Twitter
New WTA Algorithm on Airway Management – both prehospital and in-hospital algorithms. Now published and free open access in @TSACO_AAST ! Download full paper: https://t.co/MFxaWJzfdS pic.twitter.com/eZCdEC5Ys1
— WesternTrauma (@WesternTrauma) October 9, 2020