Critical Care & Emergencies (all articles)
Practice Guideline: Neuromuscular blockade in patients with ARDS
27 Oct, 2020 | 09:28h | UTCNeuromuscular blockade in patients with ARDS: a rapid practice guideline – Intensive Care Medicine (free for a limited period)
[Preprint] Randomized trial: Nitazoxanide does not improve symptoms in mild Covid-19 disease
25 Oct, 2020 | 23:46h | UTCEarly use of nitazoxanide in mild Covid-19 disease: randomized, placebo-controlled trial – medRxiv
Clinical Update: Virology, transmission, and pathogenesis of SARS-CoV-2
25 Oct, 2020 | 23:48h | UTCVirology, transmission, and pathogenesis of SARS-CoV-2 – The BMJ
Commentary on Twitter
https://twitter.com/bmj_latest/status/1320425173976256513
Perspective: The race to make COVID antibody therapies cheaper and more potent
25 Oct, 2020 | 23:43h | UTCThe race to make COVID antibody therapies cheaper and more potent – Nature
Perspective: COVID-19 can affect the heart
25 Oct, 2020 | 23:39h | UTCCOVID-19 can affect the heart – Science
Commentary from the author
https://twitter.com/EricTopol/status/1320427201351745536
Review: How to ventilate obese patients in the ICU
25 Oct, 2020 | 23:30h | UTCHow to ventilate obese patients in the ICU – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
https://twitter.com/yourICM/status/1319623153283440640
The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
25 Oct, 2020 | 23:25h | UTCOriginal guideline and commentaries: 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Randomized trial: Effects of regional citrate anticoagulation vs. systemic heparin anticoagulation on dialysis filter life span and mortality among critically ill patients with acute kidney injury
25 Oct, 2020 | 23:32h | UTC
Commentary on Twitter
In this RCT, anticoagulation with regional citrate, compared with systemic heparin, resulted in longer filter life span in patients with acute kidney injury receiving continuous kidney replacement therapy https://t.co/fmkawnqjmM #VisualAbstract
— JAMA (@JAMA_current) October 23, 2020
[Abstract only] Preliminary study suggests age-adjusted D-dimer can exclude left atrial thrombus in patients with atrial fibrillation
25 Oct, 2020 | 23:26h | UTCD-dimer blood concentrations to exclude left atrial thrombus in patients with atrial fibrillation – Heart (link to abstract – $ for full-text)
Commentary on Twitter
A nice study on the use of D-dimer for excluding left atrial thrombus.
Patients with D-dimer < (10 x patient's age) had 100% sensitivity and NPV for excluding LA thrombus.
This represented 60% of the population, who could in theory safely avoid TOE. https://t.co/OFUy9caWd0
— Mark Mills (@DrMarkMills) October 25, 2020
Down syndrome tied to 10 times the risk of COVID-19 death
23 Oct, 2020 | 09:13h | UTCDown syndrome tied to 10 times the risk of COVID-19 death – CIDRAP
Original study: COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults – Annals of Internal Medicine
Randomized trial: Convalescent plasma ineffective for patients hospitalized with Covid-19
23 Oct, 2020 | 09:15h | UTCEditorial: Convalescent plasma is ineffective for covid-19 – The BMJ
Commentary on Twitter
Just published @bmj_latest: A randomized trial of convalescent plasma for moderate covidhttps://t.co/dUvEMFSLHG
No benefit. It was underpowered to detect mortality reduction with 464 patients. A large RCT is needed to resolve the question, but these findings are not encouraging. pic.twitter.com/WGtz9IVSZe— Eric Topol (@EricTopol) October 23, 2020
Pro/con debate: Therapeutic anticoagulation in hospitalized patients with Covid-19 without established thromboembolism
23 Oct, 2020 | 09:12h | UTCAnticoagulation in Hospitalized Patients with Covid-19 – New England Journal of Medicine
Related editorial: Anticoagulation in COVID-19: It Is Time for High-Quality Evidence – Journal of the American College of Cardiology
Podcast: Deep vein thrombosis and pulmonary embolism
23 Oct, 2020 | 08:58h | UTC#238 DVT / PE Triple Distilled – The Curbsiders Internal Medicine Podcast
Best practices in managing cardiac arrest in the emergency department during the COVID-19 pandemic
22 Oct, 2020 | 09:44h | UTC
Randomized trial: Tocilizumab does not improve outcomes for patients hospitalized with Covid-19
22 Oct, 2020 | 09:42h | UTCEfficacy of Tocilizumab in Patients Hospitalized with Covid-19 – New England Journal of Medicine
New 2020 AHA Guidelines for CPR and emergency cardiovascular care in adults and children
22 Oct, 2020 | 09:47h | UTCHighlights: 2020 AHA Guidelines Update for CPR and ECC
Executive Summary: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
New calculator predicts risk of hospital admission and mortality from coronavirus 19 in adults
22 Oct, 2020 | 09:37h | UTCSee calculator: QCovid® risk calculator
Commentary on Twitter
A new "living" high quality prediction model for #COVID19 risk for hospitalization and mortality: top 20% risk accounted for 94% of deaths; https://t.co/aPXRM2pHCq calculatorhttps://t.co/gdd8b3j33K @bmj_latest
by @AshClift @JuliaHCox @OxPrimaryCare and colleagues pic.twitter.com/s8TrWWECb0— Eric Topol (@EricTopol) October 21, 2020
Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury
22 Oct, 2020 | 09:31h | UTC
Commentary on Twitter
Tranexamic acid in acute TBI
➡️ 9 RCTs/14,747 pts
➡️ probably NO effect on mortality or disability
➡️ may decrease hematoma expansion on subsequent imaging (likely of minor importance to pts)
➡️ probably NO increased risk of adverse events#FOAMcc @yourICM https://t.co/sqn80NfNv4 pic.twitter.com/dMf8rYowC2— Intensive Care Medicine (@yourICM) October 21, 2020
Studies offer little hope for Tocilizumab in treating COVID
21 Oct, 2020 | 09:27h | UTCStudies offer little hope for tocilizumab in treating COVID – CIDRAP
See studies: Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 – JAMA Internal Medicine AND Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial – JAMA Internal Medicine AND Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial – JAMA Internal Medicine
Commentary: expert reaction to three studies of Tocilizumab to treat COVID patients – Science Media Centre
Related study (preprint): Tocilizumab in Hospitalized Patients With COVID-19 Pneumonia – medRxiv
Studies point to big drop in COVID-19 death rates
21 Oct, 2020 | 09:23h | UTCStudies Point To Big Drop In COVID-19 Death Rates – NPR
Podcast: Approach to shortness of breath
21 Oct, 2020 | 09:06h | UTC
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?
20 Oct, 2020 | 01:38h | UTC
Commentary on Twitter
Side effect of #COVID19 surge: ignoring well established strategies
➡️ limit ABTs exposure vs resistances: MV/long #ICU stay
➡️ avoid toxicity: antivirals/antibiotics can have severe adverse effects/interactions
➡️ high mortality: improving outcome crucial https://t.co/FN3LtKKlsr pic.twitter.com/7KGbIOH3Uf— Intensive Care Medicine (@yourICM) October 17, 2020
Meta-analysis: The association of D-dimers with mortality, intensive care unit admission or ARDS in patients hospitalized with COVID-19
20 Oct, 2020 | 01:37h | UTC
Plastic surgery complications: A review for emergency clinicians
20 Oct, 2020 | 01:32h | UTC
Improving prone positioning for severe ARDS during the COVID-19 pandemic: An implementation mapping approach
18 Oct, 2020 | 23:17h | UTC
Commentary on Twitter
Improving Prone Positioning for Severe ARDS during the COVID-19 Pandemic: An Implementation Mapping Approach
✅ Just Accepted
🔗 https://t.co/V8K3MUdSWU pic.twitter.com/wPJCp2mKaE— Annals of the ATS (@AnnalsATS) October 13, 2020