Critical Care & Emergencies (all articles)
Randomized trial: In small infants, orotracheal intubation assisted with video laryngoscopy improves first-attempt success rate and reduces complications
17 Dec, 2020 | 08:56h | UTCFirst-attempt success rate of video laryngoscopy in small infants (VISI): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Fascinating paediatric VL study
VL
-improved FPS (esp <6.5kg)
& reduced
-attempts
-failures
-manipulations
-complications
-severe complicationsThe evidence grows that VL is simply better
Everywherehttps://t.co/f9nj6l2zk3— Tim Cook (@doctimcook) December 11, 2020
Randomized trial: In surgical patients at moderate or high risk of venous thromboembolism, pharmaco-thromboprophylaxis alone is as good as the combination of pharmaco-thromboprophylaxis and graduated compression stockings
16 Dec, 2020 | 10:00h | UTC
Observational study suggests we should individualize blood pressure targets among critically ill patients with different ranges of pre-illness baseline mean perfusion pressure
16 Dec, 2020 | 10:01h | UTCCommentary: Personalized Pressors – REACT Study Group – Journal Feed
COVID-19 mimics on chest CT: a pictorial review and radiologic guide
17 Dec, 2020 | 08:37h | UTC
Video (5min): Ivermectin for COVID-19 | A Doctor Explains
16 Dec, 2020 | 09:43h | UTCIvermectin For COVID-19 | A Doctor Explains – ZDoggMD
Report: Lung transplantation for 3 patients with severe COVID-19
16 Dec, 2020 | 09:34h | UTCLung transplantation for patients with severe COVID-19 – Science Translational Medicine
Commentaries: COVID-19 can damage lungs so badly that ‘only hope’ is transplant – MedicalXpress
Commentary on Twitter
Case reports from 3 patients with severe #COVID19 who received lung transplants show the disease can cause extensive lung damage similar to that seen in pulmonary #fibrosis, and hints transplantation may be a viable treatment. @NUFeinbergMed @ScienceTM https://t.co/wXi0tx8gFg pic.twitter.com/vyerJLlJxi
— Science Magazine (@ScienceMagazine) November 30, 2020
Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis
15 Dec, 2020 | 01:42h | UTC
[Preprint] RECOVERY trial: Azithromycin does not improve outcomes in hospitalized patients with COVID-19
15 Dec, 2020 | 01:44h | UTCNews release: RECOVERY trial finds no benefit from azithromycin in patients hospitalised with COVID-19
Commentary on Twitter
New RECOVERY result. In patients hospitalised with COVID-19, azithromycin did not provide any clinical benefit. 28 day mortality (19% vs 19%) (rate ratio 1·00; 95% confidence interval [CI] 0·90-1·12; p=0·99). No effect on secondary outcomes either.https://t.co/PTklz40WKr pic.twitter.com/NCzvRIND0S
— Peter Horby @peterhorby.bsky.social (@PeterHorby) December 14, 2020
Critical review: “I’m upset about the RELAX trial” (study showing a lower PEEP strategy is noninferior to a higher PEEP strategy in ICU patients without ARDS)
15 Dec, 2020 | 01:27h | UTCI’m upset about the RELAX trial – PulmCrit
Original study and commentaries: Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP
Commentary from the author on Twitter
RELAX trial
🧘♂️PEEP 8 cm vs. lowest possible PEEP (as low as zero!) among patients without ARDS
🧘♂️no difference in primary endpoints
🧘♂️low-PEEP caused lower PO2/FiO2 ratios, higher driving pressures, more need for rescue therapy 👎https://t.co/fGFiQyn3jY pic.twitter.com/yi2hN3yBZi— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) December 14, 2020
Randomized trial: In acutely ill children, the risk of electrolyte disorders is markedly increased with plasmalike isotonic fluid therapy compared with moderately hypotonic fluid therapy containing 20 mmol/L of potassium
15 Dec, 2020 | 01:25h | UTCRisk of Electrolyte Disorders in Acutely Ill Children Receiving Commercially Available Plasmalike Isotonic Fluids: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Commentary: Isotonic Fluids Without Potassium Could Be Harmful for Some Acutely Ill Kids – Medscape (free registration required)
Commentary on Twitter
A randomized pragmatic clinical trial shows a high risk of #hypokalemia and a small risk of #hypernatremia in acutely ill children receiving plasma-like fluid therapy https://t.co/FOoJeaSSes @TerhiTapiainen
— JAMA Pediatrics (@JAMAPediatrics) October 27, 2020
Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19
13 Dec, 2020 | 23:31h | UTCBaricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary: Baricitinib plus remdesivir shows promise for treating COVID-19 – NIH News Releases
Commentary on Twitter
Not sure how to interpret a trial for a drug plus Remdesivir vs Remdesivir alone when you don't know if Remdesivir works. @NEJM today for this combo, which has already received FDA EUAhttps://t.co/tpmHPFPJX1 pic.twitter.com/Tmue99oJnV
— Eric Topol (@EricTopol) December 11, 2020
Meta-analysis: Efficacy and harms of remdesivir for the treatment of COVID-19. “Until stronger evidence emerges, we cannot conclude that remdesivir is efficacious for treating COVID-19”.
13 Dec, 2020 | 23:27h | UTC
A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – corticosteroid treatment is not recommended for patients with mild or moderate COVID-19
13 Dec, 2020 | 23:26h | UTC
Review: Mechanical complications of acute myocardial infarction
11 Dec, 2020 | 09:19h | UTCMechanical Complications of Acute Myocardial Infarction: A Review – JAMA Cardiology
Videos: Acute Rupture of Left Ventricular Aneurysm AND Ventricular Septal Rupture AND Papillary Muscle Rupture
Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP
11 Dec, 2020 | 09:22h | UTCEditorial: Searching for the Optimal PEEP in Patients Without ARDS: High, Low, or in Between?
Video: Effect of Lower vs Higher PEEP Strategy on Ventilator-Free Days in ICU Patients Without ARDS
Commentary on Twitter
Effect of a Lower vs Higher PEEP Strategy on Ventilator-Free Days in ICU Patients Without ARDS https://t.co/h6IozSLUeS via @JAMA_current part of @JAMANetwork There is no size that fits all. PEEP titration – way to go.
— Matthias Eikermann (@MatthiasEikerm1) December 10, 2020
Systematic review: Men with COVID-19 have almost three times the risk of requiring ICU admission and a higher risk of death
10 Dec, 2020 | 08:45h | UTCCommentary: Men face ‘almost three times the odds’ of ICU admission for Covid-19, study says – CNN AND Men with COVID-19 three times more likely to need intensive care: study – MedicalXpress
Commentary on Twitter
Men w/ COVID19 are 3 times more likely to need intensive care & are at significantly higher risk of dying from the virus than women. New research analyzed over 3 million confirmed cases from 46 countries and 44 states. 2 links: https://t.co/g9nYKWxzcv
andhttps://t.co/ZOIfSYImWi— delthia ricks 🔬 (@DelthiaRicks) December 9, 2020
“Neurological manifestations of COVID-19” – guideline of the German society of neurology
9 Dec, 2020 | 08:15h | UTC
Another randomized trial shows hydroxychloroquine is not effective as postexposure prophylaxis to prevent Covid-19
9 Dec, 2020 | 08:19h | UTCSummary for patients: Summary for Patients: Postexposure Hydroxychloroquine Prophylaxis to Prevent SARS-CoV-2 Infection
Cohort study: Epidemiology and outcomes of 212 consecutive critically ill patients diagnosed with COVID-19 at Hospital Sírio-Libanês in São Paulo, Brazil
7 Dec, 2020 | 01:13h | UTC
Myocardial injury in severe COVID-19 is similar to traditional ARDS. It is a function of baseline comorbidities, advanced age, and multisystem organ dysfunction
7 Dec, 2020 | 00:59h | UTCCommentary: Myocardial Injury in Severe COVID-19 vs. ARDS – American College of Cardiology
Commentary on Twitter
About that “permanent heart damage” people associate with #COVID19…
Study published 11/13 found odds of heart damage was found to be *lower* in intubated C19 patients than in those w/ Acute Respiratory Distress Syndrome from non-Covid causes.https://t.co/rnRGFkfl0N pic.twitter.com/NN1f3DNrC7
— AJ Kay (@AJKayWriter) November 20, 2020
WHO Solidarity Trial: Remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19
3 Dec, 2020 | 08:47h | UTCAudio Interview: Caring for Hospitalized Patients with Covid-19
Commentary on Twitter (thread – click for more)
The biggest multinational pandemic randomised trial #SOLIDARITYtrial published in the New England Journal of Medicine. https://t.co/VbpbpziFwm
WHO, trial leaders, numerous countries, hospitals, doctors, nurses, patients & many others are to be congratulated!
Key results 👇🏾 1/5 pic.twitter.com/Xe9K6EfUpc
— Kari Tikkinen (@KariTikkinen) December 2, 2020
Review: Cytokine Storm
3 Dec, 2020 | 08:46h | UTCCytokine Storm – New England Journal of Medicine
Commentary on Twitter
Cytokine storm is a prominent feature in severe #COVID19. This new @NEJM review on it is as good as it gets. By @DavidFajgenbaum @carlhjune @PennMedicine https://t.co/a4qE7xGR58 pic.twitter.com/Ul1HrnL8Ve
— Eric Topol (@EricTopol) December 2, 2020
Guideline for the perioperative management of hip fractures 2020
3 Dec, 2020 | 08:30h | UTCGuideline for the management of hip fractures 2020 – Anaesthesia
Commentary on Twitter
🔐This new @Assoc_Anaes guideline for the management of hip fractures from @IainMoppett and colleagues contains more specific recommendations about controversial areas of patient management than were made in 2011.
Available now and #FOAMed forever!
🔗https://t.co/B5cdxSx2mU pic.twitter.com/8nQiUNpdS2
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) December 2, 2020
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
NICE COVID-19 guideline: Prevention of thromboembolism in patients with COVID-19. “For patients who are having advanced respiratory support: consider increasing pharmacological VTE prophylaxis to an intermediate dose”
1 Dec, 2020 | 08:19h | UTC