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Critical Care & Emergencies (all articles)

M-A of randomized trials: The effect of higher versus lower protein delivery in critically ill patients – “In critically ill patients, a higher daily protein delivery was not associated with any improvement in clinical or patient-centered outcomes”.

20 Aug, 2021 | 08:57h | UTC

The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials – Critical Care

 

Variations in end-of-life practices in intensive care units worldwide: a prospective observational study.

20 Aug, 2021 | 08:51h | UTC

Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection.

20 Aug, 2021 | 08:41h | UTC

Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection – JAC-Antimicrobial Resistance

 

Review: Viral respiratory pathogens and lung injury.

20 Aug, 2021 | 08:43h | UTC

Viral Respiratory Pathogens and Lung Injury – Clinical Microbiology Reviews

 

Viewpoint: Confronting the Delta variant of SARS-CoV-2.

19 Aug, 2021 | 09:03h | UTC

Confronting the Delta Variant of SARS-CoV-2, Summer 2021 – JAMA

 

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms.

19 Aug, 2021 | 09:06h | UTC

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms – NIH News Releases

Original study: Early Convalescent Plasma for High-Risk Outpatients with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

 

Hemophagocytic lymphohistiocytosis secondary to COVID-19: a case series.

19 Aug, 2021 | 08:57h | UTC

Haemophagocytic lymphohistiocytosis secondary to COVID-19: a case series – The Lancet Rheumatology

 

Delirium in critical illness: clinical manifestations, outcomes, and management.

18 Aug, 2021 | 08:47h | UTC

Delirium in critical illness: clinical manifestations, outcomes, and management – Intensive Care Medicine (if this link does not work, try this one)

Related:

M-A: Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients.

ICU Survivorship—The relationship of delirium, sedation, dementia, and acquired weakness.

Systematic review: In hospitalized non‐ICU patients, multicomponent non-pharmacological interventions are estimated to reduce the incidence of delirium by 43% compared to usual care.

 

Commentary on Twitter

 

Systematic review: Systemic corticosteroids for the treatment of COVID‐19.

17 Aug, 2021 | 09:11h | UTC

Systemic corticosteroids for the treatment of COVID‐19 – Cochrane Library

Summary: Are corticosteroids given orally or by injection an effective treatment for people with COVID-19? – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

Top antimicrobial stewardship intervention publications in 2020.

17 Aug, 2021 | 08:51h | UTC

A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2020 – Open Forum Infectious Diseases

 

P/FP ratio: incorporation of PEEP into the PaO2/FiO2 ratio for prognostication and classification of acute respiratory distress syndrome.

17 Aug, 2021 | 08:46h | UTC

P/FP ratio: incorporation of PEEP into the PaO2/FiO2 ratio for prognostication and classification of acute respiratory distress syndrome – Annals of Intensive Care

 

Commentary on Twitter

 

Cohort study: Early invasive coronary angiography in patients with acute ischemic heart failure is linked to better outcomes.

17 Aug, 2021 | 08:44h | UTC

Early invasive coronary angiography and acute ischaemic heart failure outcomes – European Heart Journal

Commentary: Early Invasive Angiography in Acute Heart Failure – American College of Cardiology

 

Commentary on Twitter

 

Review: Initial management of blunt and penetrating neck trauma.

17 Aug, 2021 | 08:40h | UTC

Initial management of blunt and penetrating neck trauma – BJA Education

 

EM Cases: Testicular Torsion: A Diagnostic Pathway – “Time is Testes”.

17 Aug, 2021 | 08:41h | UTC

EM Cases: Testicular Torsion: A Diagnostic Pathway – emDocs

 

Out of hospital cardiac arrest: Past, present, and future.

17 Aug, 2021 | 08:39h | UTC

Out of hospital cardiac arrest: Past, present, and future – Resuscitation

 

Guideline: Acute abdomen in the immunocompromised patient.

16 Aug, 2021 | 01:00h | UTC

Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines – World Journal of Emergency Surgery

 

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

16 Aug, 2021 | 00:55h | UTC

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine (free for a limited period)

Related: RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

Commentary on Twitter

 

Expert analysis: PCI for Multivessel Disease in STEMI.

16 Aug, 2021 | 00:49h | UTC

PCI for Multivessel Disease in STEMI – American College of Cardiology

 

Commentaries on Twitter

 

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

13 Aug, 2021 | 09:58h | UTC

Could This Be Our First Effective, Inexpensive, Widely Available Outpatient Treatment for COVID-19? – HIV and ID Observations

Related: Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

13 Aug, 2021 | 10:01h | UTC

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison – American Family Physician

Related:

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 

How COVID-19 will change the management of other respiratory viral infections.

13 Aug, 2021 | 09:52h | UTC

How COVID-19 will change the management of other respiratory viral infections – Intensive Care Medicine

 

Commentary on Twitter

 

M-A: Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients.

13 Aug, 2021 | 09:01h | UTC

Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis – Intensive Care Medicine

 

Commentary on Twitter

 

Review: Oxygenation strategies after extubation of critically ill and postoperative patients.

13 Aug, 2021 | 08:49h | UTC

Oxygenation strategies after extubation of critically ill and postoperative patients – Journal of Intensive Medicine

 

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

12 Aug, 2021 | 09:05h | UTC

Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis – New England Journal of Medicine

Commentary: Largest Study of VITT After COVID-19 Vaccination Digs Into Lab, Clinical Features – TCTMD

Related:

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Commentary on Twitter

 

2021 guidelines for management of venous thromboembolism in Latin America.

12 Aug, 2021 | 08:56h | UTC

ASH, ABHH, ACHO, Grupo CAHT, Grupo  CLAHT, SAH, SBHH, SHU, SOCHIHEM, SOMETH, Sociedad Panameña de Hematología, SPH, and SVH 2021 guidelines for management of venous thromboembolism in Latin America – Blood Advances

 

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