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Emergency Medicine

Review: Initial management of blunt and penetrating neck trauma.

17 Aug, 2021 | 08:40h | UTC

Initial management of blunt and penetrating neck trauma – BJA Education

 

EM Cases: Testicular Torsion: A Diagnostic Pathway – “Time is Testes”.

17 Aug, 2021 | 08:41h | UTC

EM Cases: Testicular Torsion: A Diagnostic Pathway – emDocs

 

Out of hospital cardiac arrest: Past, present, and future.

17 Aug, 2021 | 08:39h | UTC

Out of hospital cardiac arrest: Past, present, and future – Resuscitation

 

Guideline: Acute abdomen in the immunocompromised patient.

16 Aug, 2021 | 01:00h | UTC

Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines – World Journal of Emergency Surgery

 

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

16 Aug, 2021 | 00:55h | UTC

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine (free for a limited period)

Related: RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

Commentary on Twitter

 

Expert analysis: PCI for Multivessel Disease in STEMI.

16 Aug, 2021 | 00:49h | UTC

PCI for Multivessel Disease in STEMI – American College of Cardiology

 

Commentaries on Twitter

 

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

13 Aug, 2021 | 09:58h | UTC

Could This Be Our First Effective, Inexpensive, Widely Available Outpatient Treatment for COVID-19? – HIV and ID Observations

Related: Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

13 Aug, 2021 | 10:01h | UTC

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison – American Family Physician

Related:

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 

How COVID-19 will change the management of other respiratory viral infections.

13 Aug, 2021 | 09:52h | UTC

How COVID-19 will change the management of other respiratory viral infections – Intensive Care Medicine

 

Commentary on Twitter

 

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

12 Aug, 2021 | 09:05h | UTC

Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis – New England Journal of Medicine

Commentary: Largest Study of VITT After COVID-19 Vaccination Digs Into Lab, Clinical Features – TCTMD

Related:

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Commentary on Twitter

 

2021 guidelines for management of venous thromboembolism in Latin America.

12 Aug, 2021 | 08:56h | UTC

ASH, ABHH, ACHO, Grupo CAHT, Grupo  CLAHT, SAH, SBHH, SHU, SOCHIHEM, SOMETH, Sociedad Panameña de Hematología, SPH, and SVH 2021 guidelines for management of venous thromboembolism in Latin America – Blood Advances

 

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

11 Aug, 2021 | 08:52h | UTC

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – The Lancet

Invited Commentary: The use of inhaled corticosteroids in early-stage COVID-19

 

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

11 Aug, 2021 | 08:37h | UTC

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? – JAMA (free for a limited period)

Video: Balanced Solution vs. Saline in Intensive Care Study

 

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

11 Aug, 2021 | 08:44h | UTC

Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine–Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis: A Review – JAMA Cardiology

Related:

NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Commentary on Twitter

https://twitter.com/JohnGRizk/status/1425126093288353800

 

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

11 Aug, 2021 | 08:39h | UTC

Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill PatientsThe BaSICS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU? – JAMA (free for a limited period)

Video: Balanced Solution vs. Saline in Intensive Care Study

 

Commentary on Twitter

 

RCT: Triaging acute pulmonary embolism for home treatment by Hestia vs. simplified PESI criteria – the tools were similarly effective, and more than a third of patients were treated at home with a low incidence of complications.

11 Aug, 2021 | 08:27h | UTC

Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial – European Heart Journal

 

Commentary on Twitter

 

Update on medical management of acute hip fracture.

10 Aug, 2021 | 08:50h | UTC

Update on medical management of acute hip fracture – Cleveland Clinical Journal of Medicine

 

Commentary on Twitter

 

Evidence-based approach to nailbed injuries: ED presentations, evaluation, and management.

10 Aug, 2021 | 08:47h | UTC

Evidence-based Approach to Nailbed Injuries: ED Presentations, Evaluation, and management – emDocs

 

Case report: Systemic capillary leak syndrome after ChAdOx1 nCOV-19 (Oxford–AstraZeneca) vaccination.

8 Aug, 2021 | 23:49h | UTC

Systemic capillary leak syndrome afer ChAdOx1 nCOV-19 (Oxford–AstraZeneca) vaccination – Canadian Medical Association Journal

 

[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

6 Aug, 2021 | 10:18h | UTC

An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 – medRxiv

Commentary: Covid: Pressured oxygen reduces ventilator need – BBC

 

Commentary on Twitter (thread – click for more)

 

Review: Transmission of infections during cardiopulmonary resuscitation.

8 Aug, 2021 | 23:16h | UTC

Transmission of Infections during Cardiopulmonary Resuscitation – Clinical Microbiology Reviews

 

Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.

6 Aug, 2021 | 10:15h | UTC

Remdesivir for the treatment of COVID‐19 – Cochrane Library

Summary: Remdesivir for the treatment of COVID-19 – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.

6 Aug, 2021 | 10:09h | UTC

Mucormycosis after COVID-19 in a patient with diabetes – The Lancet

Related:

COVID-19 and mucormycosis superinfection: the perfect storm.

ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries.

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

What is mucormycosis, the fungal infection affecting COVID patients in India?

[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.

Mucormycosis: The ‘black fungus’ maiming Covid patients in India

Global Guideline for the Diagnosis and Management of Mucormycosis

 

Review: Rational fluid resuscitation in sepsis for the hospitalist.

6 Aug, 2021 | 09:53h | UTC

A Narrative Review Rational Fluid Resuscitation in Sepsis for the Hospitalist: A Narrative Review – Mayo Clinic Proceedings

 

Researchers tell doctors to avoid routine urinary tests for older patients with delirium.

6 Aug, 2021 | 09:01h | UTC

Researchers tell doctors to avoid routine urinary tests for older patients with delirium – Johns Hopkins University School of Medicine

Original article: Things We Do for No Reason™: Obtaining Urine Testing in Older Adults With Delirium Without Signs or Symptoms of Urinary Tract Infection – Journal of Hospital Medicine ($)

 

Commentary on Twitter (thread – click for more)

 

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